KEGG   DRUG: Methylprednisolone acetateHelp
Entry
D00979                      Drug                                   

Name
Methylprednisolone acetate (JAN/USP);
Depo-medrol (TN)
Product
  Generic
Formula
C24H32O6
Exact mass
416.2199
Mol weight
416.5073
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C08179
Therapeutic category: 2456
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mcosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond blackfan anemia [DS:H00237]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Discoid lupus erythematosus [DS:H01595]
Lichen planus [DS:H01654]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00979  Methylprednisolone acetate (JAN/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00979  Methylprednisolone acetate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00979  Methylprednisolone acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
BRITE hierarchy
Other DBs
CAS: 53-36-1
PubChem: 7848042
ChEBI: 6889
ChEMBL: CHEMBL1364144 CHEMBL1474440 CHEMBL66870
DrugBank: DB00959
LigandBox: D00979
NIKKAJI: J4.144K
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2x C     6.3700  -24.5700
            2   C5x C     6.3700  -25.9700
            3   C2x C     7.5824  -26.6700
            4   C2y C     8.7949  -25.9700
            5   C1z C     8.7949  -24.5700
            6   C2x C     7.5824  -23.8700
            7   C1y C    10.0073  -26.6700
            8   C1x C    11.2197  -25.9700
            9   C1y C    11.2197  -24.5700
            10  C1y C    10.0073  -23.8700
            11  C1y C    12.4322  -23.8700
            12  C1z C    12.4322  -22.4700
            13  C1x C    11.2197  -21.7700
            14  C1y C    10.0073  -22.4700
            15  C1x C    14.8570  -23.8700
            16  C1x C    14.8570  -22.4700
            17  C1z C    13.6446  -21.7700
            18  O5x O     5.1576  -26.6700
            19  C1a C     8.7949  -23.1700
            20  O1a O     8.7969  -21.7712
            21  C1a C    12.4322  -21.0700
            22  C5a C    13.6446  -20.0900
            23  C1a C    10.0073  -28.0700
            24  O1a O    14.8570  -21.0700
            25  C1b C    14.8611  -19.3877
            26  O5a O    12.4362  -19.3923
            27  O7a O    16.0586  -20.0792
            28  C7a C    17.2449  -19.3943
            29  C1a C    18.4367  -20.0826
            30  O6a O    17.2451  -17.9902
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2

» Japanese version   » Back

DBGET integrated database retrieval system