KEGG   DRUG: LanoconazoleHelp
Entry
D01092                      Drug                                   

Name
Lanoconazole (JP17/INN);
Latoconazole;
Astat (TN)
Formula
C14H10ClN3S2
Exact mass
319.0005
Mol weight
319.8323
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antifungal
 DG01883  Imidazole antifungal
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Therapeutic category: 2655
Product: D01092<JP>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Drug interaction
Structure map
map07026  Antifungal agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D01092  Lanoconazole (JP17/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  58 Ringworm drugs
   D01092  Lanoconazole (JP17/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Lanoconazole
    D01092  Lanoconazole (JP17/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lanoconazole
    D01092  Lanoconazole (JP17/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01092  Lanoconazole
  D01092  Lanoconazole cutaneous solution
  D01092  Lanoconazole ointment
  D01092  Lanoconazole cream
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01092
Rx-to-OTC switch list in Japan [br08314.html]
 D01092
BRITE hierarchy
Other DBs
CAS: 101530-10-3
PubChem: 7848155
ChEBI: 31761
ChEMBL: CHEMBL1555126
LigandBox: D01092
NIKKAJI: J421.471D
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8x C     7.9800  -18.0600
            2   C8x C     7.9800  -19.4600
            3   C8x C     9.1924  -20.1600
            4   C8y C    10.4049  -19.4600
            5   C8y C    10.4049  -18.0600
            6   C8x C     9.1924  -17.3600
            7   X   Cl   11.6173  -20.1600
            8   C1y C    11.6173  -17.3600
            9   C1x C    11.6173  -15.9600
            10  S2x S    12.9488  -17.7926
            11  C2y C    13.7717  -16.6600
            12  S2x S    12.9488  -15.5274
            13  C2c C    15.1900  -16.6600
            14  C3b C    15.8900  -17.8724
            15  N4y N    15.8900  -15.4476
            16  C8x C    17.2900  -15.4476
            17  N5x N    17.7226  -14.1161
            18  C8x C    16.5900  -13.2932
            19  C8x C    15.4574  -14.1161
            20  N3a N    16.5900  -19.0849
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1
            11   10  11 1
            12   11  12 1
            13    9  12 1
            14   11  13 2
            15   13  14 1
            16   13  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   15  19 1
            22   14  20 3

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