KEGG   DRUG: Profenamine hydrochlorideHelp
Entry
D01118                      Drug                                   

Name
Profenamine hydrochloride (JAN);
Ethopropazine hydrochloride;
Parkin (TN);
Parsidol (TN)
Formula
C19H24N2S. HCl
Exact mass
348.1427
Mol weight
348.9332
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AA05
Chemical structure group: DG00855
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
  Disease
Parkinsonism [DS:H01600]
Comment
Phenothiazine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA05 Profenamine
      D01118  Profenamine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D01118  Profenamine hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 1094-08-2
PubChem: 7848181
ChEBI: 31568
ChEMBL: CHEMBL1200970
DrugBank: DB00392
LigandBox: D01118
NIKKAJI: J252.869J
LinkDB All DBs
KCF data Show

ATOM        23
            1   C8x C     7.2100   -9.8000
            2   C8x C     7.2100  -11.2000
            3   C8x C     8.4224  -11.9000
            4   C8y C     9.6349  -11.2000
            5   C8y C     9.6349   -9.8000
            6   C8x C     8.4224   -9.1000
            7   S2x S    10.8473  -11.9000
            8   C8y C    12.0597  -11.2000
            9   C8y C    12.0597   -9.8000
            10  N4y N    10.8473   -9.1000
            11  C8x C    13.2722  -11.9000
            12  C8x C    14.4846  -11.2000
            13  C8x C    14.4846   -9.8000
            14  C8x C    13.2722   -9.1000
            15  C1b C    10.8473   -7.7000
            16  C1c C    12.0618   -6.9988
            17  C1a C    13.2583   -7.6898
            18  N1c N    12.0618   -5.6002
            19  C1b C    13.2579   -4.9095
            20  C1b C    10.8330   -4.8906
            21  C1a C     9.6293   -5.5855
            22  C1a C    14.4453   -5.5951
            23  X   Cl   18.6900  -10.1500
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    8  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    9  14 1
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   16  18 1
            21   18  19 1
            22   18  20 1
            23   20  21 1
            24   19  22 1

» Japanese version   » Back

KEGG   DRUG: Profenamine hibenzateHelp
Entry
D03276                      Drug                                   

Name
Profenamine hibenzate (JAN);
Parkin (TN)
Formula
C19H24N2S. C14H10O4
Exact mass
554.2239
Mol weight
554.6991
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AA05
Chemical structure group: DG00855
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
Comment
Phenothiazine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA05 Profenamine
      D03276  Profenamine hibenzate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D03276  Profenamine hibenzate (JAN)
BRITE hierarchy
Other DBs
PubChem: 17397428
LigandBox: D03276
LinkDB All DBs
KCF data Show

ATOM        40
            1   C8y C     4.2000  -19.3900
            2   C8y C     4.2000  -20.7900
            3   S2x S     5.3900  -21.4900
            4   C8y C     6.6500  -20.7900
            5   C8y C     6.6500  -19.3900
            6   N1y N     5.3900  -18.6900
            7   C8x C     7.8400  -21.4900
            8   C8x C     9.0300  -20.7900
            9   C8x C     9.0300  -19.3900
            10  C8x C     7.8400  -18.6900
            11  C8x C     3.0100  -18.6900
            12  C8x C     1.7500  -19.3900
            13  C8x C     1.7500  -20.7900
            14  C8x C     3.0100  -21.4900
            15  C1b C     5.3900  -17.2900
            16  C1c C     6.6500  -16.5900
            17  N1c N     6.6500  -15.1900
            18  C1b C     7.8400  -14.4900
            19  C1a C     8.9600  -15.1900
            20  C1a C     7.8400  -17.2900
            21  C1b C     5.4600  -14.4900
            22  C1a C     4.2700  -15.1900
            23  C8x C    14.2100  -19.3200
            24  C8x C    14.2100  -20.7200
            25  C8x C    15.4700  -21.4200
            26  C8x C    16.6600  -20.7200
            27  C8y C    16.6600  -19.3200
            28  C8y C    15.4700  -18.6200
            29  C5a C    17.8500  -18.6200
            30  C8y C    19.1100  -19.3200
            31  C8x C    19.1100  -20.7200
            32  C8x C    20.3000  -21.4200
            33  C8y C    21.4900  -20.7200
            34  C8x C    21.4900  -19.3200
            35  C8x C    20.3000  -18.6200
            36  C6a C    15.4700  -17.2200
            37  O6a O    16.6600  -16.5200
            38  O6a O    14.2100  -16.5200
            39  O5a O    17.8500  -17.2200
            40  O1a O    22.7053  -21.4151
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    1  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    2  14 1
            17    6  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   16  20 1
            23   17  21 1
            24   21  22 1
            25   29  39 2
            26   29  30 1
            27   23  24 2
            28   24  25 1
            29   25  26 2
            30   26  27 1
            31   27  28 2
            32   30  31 2
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 2
            37   35  30 1
            38   28  23 1
            39   28  36 1
            40   36  37 1
            41   27  29 1
            42   36  38 2
            43   33  40 1

» Japanese version   » Back

KEGG   DRUG: ProfenamineHelp
Entry
D08426                      Drug                                   

Name
Profenamine (INN)
Formula
C19H24N2S
Exact mass
312.166
Mol weight
312.4723
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AA05
Chemical structure group: DG00855
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
Comment
Phenothiazine derivative
centrally active anticholinergic drugs
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA05 Profenamine
      D08426  Profenamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D08426  Profenamine (INN)
BRITE hierarchy
Other DBs
CAS: 522-00-9
PubChem: 96025112
ChEBI: 313639
ChEMBL: CHEMBL1206
DrugBank: DB00392
LigandBox: D08426
NIKKAJI: J2.060E
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C    20.5100  -19.3200
            2   C8x C    20.5100  -20.7200
            3   C8x C    21.7700  -21.4200
            4   C8y C    22.9600  -20.7200
            5   C8y C    22.9600  -19.3200
            6   C8x C    21.7700  -18.6200
            7   S2x S    24.1500  -21.4200
            8   C8y C    25.4100  -20.7200
            9   C8y C    25.4100  -19.3200
            10  N4y N    24.1500  -18.6200
            11  C8x C    26.6000  -21.4200
            12  C8x C    27.7900  -20.7200
            13  C8x C    27.7900  -19.3200
            14  C8x C    26.6000  -18.6200
            15  C1b C    24.1500  -17.2200
            16  C1c C    25.4100  -16.5200
            17  C1a C    26.6000  -17.2200
            18  N1c N    25.4100  -15.1200
            19  C1b C    26.6000  -14.4200
            20  C1b C    24.1500  -14.4200
            21  C1a C    22.9600  -15.1200
            22  C1a C    27.7900  -15.1200
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    8  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    9  14 1
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   16  18 1
            21   18  19 1
            22   18  20 1
            23   20  21 1
            24   19  22 1

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