KEGG   DRUG: Leucovorin calciumHelp
Entry
D01211                      Drug                                   

Name
Leucovorin calcium (USP);
Calcium folinate (JP17);
Uzel (TN);
Wellcovorin (TN)
Product
  Generic
LEUCOVORIN CALCIUM (American Health Packaging), LEUCOVORIN (BluePoint Laboratories), LEUCOVORIN CALCIUM (Fresenius Kabi USA), LEUCOVORIN CALCIUM (Fresenius Kabi USA), LEUCOVORIN CALCIUM (Fresenius Kabi USA), LEUCOVORIN CALCIUM (Fresenius Kabi USA), LEUCOVORIN CALCIUM (Ingenus Pharmaceuticals), LEUCOVORIN CALCIUM (Major Pharmaceuticals), LEUCOVORIN CALCIUM (Mylan Institutional), LEUCOVORIN CALCIUM (Mylan Institutional LLC), LEUCOVORIN CALCIUM (Sagent Pharmaceuticals), LEUCOVORIN CALCIUM (Sagent Pharmaceuticals), LEUCOVORIN CALCIUM (Sagent Pharmaceuticals), LEUCOVORIN CALCIUM (Teva Parenteral Medicines), LEUCOVORIN CALCIUM (Teva Parenteral Medicines), LEUCOVORIN CALCIUM (Teva Pharmaceuticals USA), LEUCOVORIN CALCIUM (West-Ward Pharmaceuticals Corp), LEUCOVORIN CALCIUM (West-Ward Pharmaceuticals Corp.)
Formula
C20H21N7O7. Ca
Exact mass
511.1128
Mol weight
511.5014
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 3929
ATC code: V03AF03
Chemical structure group: DG02073
Product (DG02073): D01211<JP/US>
Efficacy
Anti-anemic (folate deficiency), Antidote (antifolate), Antineoplastic (enhancer), Supplement (folic acid)
  Disease
Osteosarcoma [DS:H00036]
Colorectal cancer [DS:H00020]
Comment
Tetrahydrofolic acid [CPD:C00101] derivative
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF03 Calcium folinate
      D01211  Leucovorin calcium (USP) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Leucovorin
    D01211  Leucovorin calcium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   392  Antidotes
    3929  Others
     D01211  Leucovorin calcium (USP); Calcium folinate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01211  Calcium folinate
BRITE hierarchy
Other DBs
CAS: 1492-18-8
PubChem: 7848274
ChEBI: 31340
ChEMBL: CHEMBL1201138 CHEMBL1908361
DrugBank: DB00650
LigandBox: D01211
NIKKAJI: J29.064E
LinkDB All DBs
KCF data Show

ATOM        35
            1   C1c C    24.0800  -14.7700
            2   C1b C    25.2700  -15.4700
            3   C6a C    24.0800  -13.3700
            4   C8y C    11.9700  -17.6400
            5   N1y N    13.1600  -16.9400
            6   C8y C    11.9700  -19.0400
            7   C8y C    10.7100  -16.9400
            8   C1y C    14.4200  -17.6400
            9   N1x N    13.1600  -19.7400
            10  N4x N    10.7100  -19.7400
            11  N5x N     9.5200  -17.6400
            12  O5x O    10.7100  -15.5400
            13  C1x C    14.4200  -19.0400
            14  C1b C    15.6100  -16.9400
            15  C8y C     9.5200  -19.0400
            16  N1a N     8.3300  -19.7400
            17  N1b N    16.8000  -17.6400
            18  C8y C    17.9900  -16.9400
            19  C8x C    17.9900  -15.5400
            20  C8x C    19.1800  -14.8400
            21  C8y C    20.4400  -15.5400
            22  C8x C    20.4400  -16.9400
            23  C8x C    19.2500  -17.6400
            24  C5a C    21.6300  -14.8400
            25  N1b N    22.8900  -15.5400
            26  O5a O    21.6300  -13.4400
            27  O6a O    25.2700  -12.6700 #-
            28  C1b C    26.4600  -14.7700
            29  O6a O    22.8900  -12.6700
            30  C6a C    27.6500  -15.4700
            31  O6a O    28.9100  -14.7000 #-
            32  O6a O    27.6500  -16.8700
            33  C4a C    13.1600  -15.5400
            34  O4a O    14.3500  -14.8400
            35  Z   Ca   27.3000  -13.0900 #2+
BOND        36
            1     1   2 1
            2     1   3 1 #Down
            3     4   5 1
            4     4   6 2
            5     4   7 1
            6     5   8 1
            7     6   9 1
            8     6  10 1
            9     7  11 1
            10    7  12 2
            11    8  13 1
            12    8  14 1
            13   10  15 1
            14   15  16 1
            15    9  13 1
            16   11  15 2
            17   14  17 1
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   21  24 1
            26   24  25 1
            27   24  26 2
            28    1  25 1
            29    3  27 1
            30    2  28 1
            31    3  29 2
            32   28  30 1
            33   30  31 1
            34   30  32 2
            35    5  33 1
            36   33  34 2

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