KEGG   DRUG: Hydralazine hydrochlorideHelp
Entry
D01302                      Drug                                   

Name
Hydralazine hydrochloride (JP17/USP);
Apresoline (TN)
Product
  Generic
HYDRALAZINE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), HYDRALAZINE HYDROCHLORIDE (Akorn), HYDRALAZINE HYDROCHLORIDE (Akorn), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Appco Pharma LLC), HYDRALAZINE HYDROCHLORIDE (Ascend Laboratories), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), HYDRALAZINE HYDROCHLORIDE (Camber Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Cardinal Health), HYDRALAZINE HYDROCHLORIDE (Contract Pharmacy Services-PA), HYDRALAZINE HYDROCHLORIDE (Exelan Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (General Injectables & Vaccines), HYDRALAZINE HYDRCHLORIDE (General Injectables and Vaccines), HYDRALAZINE HYDROCHLORIDE (Glenmark Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Heritage Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDRALAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDRALAZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (McKesson Corporation), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Mylan Institutional), HYDRALAZINE HYDROCHLORIDE (Mylan Institutional LLC), HYDRALAZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDRALAZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDRALAZINE (Nivagen Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (Rebel Distributors Corp), HYDRALAZINE HYDROCHLORIDE (Safecor Health), HYDRALAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), HYDRALAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), HYDRALAZINE HYDROCHLORIDE (Strides Pharma), HYDRALAZINE HYDROCHLORIDE (Strides Shasun Limited), HYDRALAZINE HYDROCHLORIDE (Teva Pharmaceuticals USA), HYDRALAZINE HYDROCHLORIDE (Unit Dose Services), HYDRALAZINE HYDROCHLORIDE (Unit Dose Services), HYDRALAZINE HYDROCHLORIDE (Unit Dose Services), HYDRALAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals)
Formula
C8H8N4. HCl
Exact mass
196.0516
Mol weight
196.6369
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG02046  Hydrazinophthalazine derivative
Metabolizing enzyme substrate
 DG02928  NAT substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 2142
ATC code: C02DB02
Chemical structure group: DG00261
Product (DG00261): D01302<JP/US>
Product (mixture): D10209<US>
Efficacy
Antihypertensive
  Disease
Essential hypertension [DS:H01633]
Comment
Hydrazinophthalazine derivative
Metabolism
Enzyme: NAT [HSA:9 10]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DB Hydrazinophthalazine derivatives
     C02DB02 Hydralazine
      D01302  Hydralazine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators, Direct-acting Arterial
   Hydralazine
    D01302  Hydralazine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2142  Hydralazines
     D01302  Hydralazine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01302  Hydralazine hydrochloride
  D01302  Hydralazine hydrochloride tablets
  D01302  Hydralazine hydrochloride powder
  D01302  Hydralazine hydrochloride for injection
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D01302
BRITE hierarchy
Other DBs
CAS: 304-20-1
PubChem: 7848365
ChEBI: 31672
ChEMBL: CHEMBL542541
DrugBank: DB01275
LigandBox: D01302
NIKKAJI: J257.318K
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8x C    19.0523  -16.4104
            2   C8x C    19.0523  -17.8110
            3   C8x C    20.2682  -18.5113
            4   C8x C    20.2682  -15.7101
            5   C8y C    21.4769  -16.4104
            6   C8y C    21.4710  -17.8110
            7   C8x C    22.6809  -18.5163
            8   N5x N    23.8968  -17.8213
            9   N5x N    23.9027  -16.4208
            10  C8y C    22.6928  -15.7154
            11  N1b N    22.6987  -14.3148
            12  N1a N    23.9148  -13.6196
            13  X   Cl   28.1844  -16.5518
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   6 2
            4     5   4 2
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10   5 1
            11    4   1 1
            12   10  11 1
            13   11  12 1

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