KEGG   DRUG: Tramadol hydrochloride
Entry
D01355                      Drug                                   

Name
Tramadol hydrochloride (JP18/USP);
Ultram (TN)
Product
  Generic
ULTRAM (Advanced Rx Pharmacy of Tennessee), CONZIP (Advanced Rx Pharmacy of Tennessee), ULTRAM (Advanced Rx Pharmacy of Tennessee), CONZIP (Advanced Rx Pharmacy of Tennessee), CONZIP (Advanced Rx Pharmacy of Tennessee), ULTRAM (Advanced Rx Pharmacy of Tennessee), ULTRAM (Advanced Rx Pharmacy of Tennessee), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE (Advagen Pharma Limited), TRAMADOL HYDROCHLORIDE (American Health Packaging), TRAMADOL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAMADOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAMADOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAMADOL HYDROCHLORIDE (Asclemed USA), TRAMADOL HYDROCHLORIDE (Aurobindo Pharma Limited), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Cadila Healthcare Limited), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Clinical Solutions Wholesale), TRAMADOL HYDROCHLORIDE (Contract Pharmacy Services-PA), TRAMADOL HYDROCHLORIDE (DIRECT RX), TRAMADOL HYDROCHLORIDE (DIRECT RX), TRAMADOL HYDROCHLORIDE (DIRECT RX), TRAMADOL HYDROCHLORIDE (Denton Pharma), TRAMADOL HYDROCHLORIDE (Denton Pharma), TRAMADOL HYDROCHLORIDE (DirectRX), TRAMADOL HYDROCHLORIDE (Direct_Rx), TRAMADOL HYDROCHLORIDE (Golden State Medical Supply), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lupin Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Major Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Medsource Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Medsource Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Mylan Institutional), TRAMADOL HYDROCHLORIDE (Mylan Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Mylan Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NCS HealthCare of KY), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Par Pharmaceutical), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (Quality Care Products), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (RPK Pharmaceuticals), TRAMADOL HYDROCHLORIDE (RPK Pharmaceuticals), TRAMADOL HYDROCHLORIDE (RedPharm Drug), TRAMADOL HYDROCHLORIDE (RedPharm Drug), TRAMADOL HYDROCHLORIDE (RedPharm Drug), TRAMADOL HYDROCHLORIDE (RedPharm Drug), TRAMADOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAMADOL HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAMADOL HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAMADOL HYDROCHLORIDE (TRUPHARMA LLC), TRAMADOL HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAMADOL HYDROCHLORIDE (Trigen Laboratories), TRAMADOL HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), TRAMADOL HYDROCHLORIDE (Virtus Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), TRAMADOL HYDROCHLORIDE (medsource pharmaceuticals), TRAMADOL HYDROCHLORIDE (medsource pharmaceuticals), TRAMADOL HYDROCHLORIDE (medsource pharmaceuticals), TRAMADOL HYDROCHLORIDE (medsource pharmaceuticals), TRAMADOL HYDROCHLORIDE (Golden State Medical Supply)
Formula
C16H25NO2. HCl
Exact mass
299.1652
Mol weight
299.8361
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1149
ATC code: N02AX02
Chemical structure group: DG00824
Product (DG00824): D01355<JP/US>
Product (mixture): D09999<JP/US>
Efficacy
Analgesic, Opioid receptor agonist
Comment
Phenol ethers
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AX Other opioids
     N02AX02 Tramadol
      D01355  Tramadol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Tramadol
    D01355  Tramadol hydrochloride (JP18/USP)
  Opioid Analgesics, Short-acting
   Tramadol
    D01355  Tramadol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01355  Tramadol hydrochloride (JP18/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01355  Tramadol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01355  Tramadol hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01355
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01355
Other DBs
CAS: 36282-47-0
PubChem: 7848418
ChEBI: 32250
ChEMBL: CHEMBL1200336
DrugBank: DB00193
LigandBox: D01355
NIKKAJI: J299.777K
LinkDB
KCF data

ATOM        20
            1   C1z C    21.0055  -18.6181
            2   C8y C    22.2165  -19.3259
            3   C1y C    21.0114  -17.2258
            4   C1x C    19.7888  -19.3201
            5   O1a O    21.0114  -20.0162
            6   C8x C    23.4274  -18.6298
            7   C8x C    22.2107  -20.7299
            8   C1x C    19.7945  -16.5238
            9   C1b C    22.2222  -16.5238
            10  C1x C    18.5836  -18.6239
            11  C8y C    24.6325  -19.3318
            12  C8x C    23.4215  -21.4319
            13  C1x C    18.5778  -17.2258
            14  N1c N    22.2222  -15.1257
            15  C8x C    24.6384  -20.7359
            16  O2a O    25.8494  -18.6298
            17  C1a C    23.4332  -14.4236
            18  C1a C    21.0114  -14.4236
            19  C1a C    27.0603  -19.3318
            20  X   Cl   31.3776  -18.7645
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    6  11 1
            11    7  12 2
            12    8  13 1
            13    9  14 1
            14   11  15 2
            15   11  16 1
            16   14  17 1
            17   14  18 1
            18   16  19 1
            19   10  13 1
            20   12  15 1

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