KEGG   DRUG: Betamethasone valerateHelp
Entry
D01357                      Drug                                   

Name
Betamethasone valerate (JP17/USP);
Beta-Val (TN);
Luxiq (TN);
Rinderon-V (TN)
Product
  Generic
BETAMETHASONE VALERATE (A-S Medication Solutions), BETAMETHASONE VALERATE (A-S Medication Solutions), BETAMETHASONE VALERATE (A-S Medication Solutions), BETAMETHASONE VALERATE (A-S Medication Solutions), BETAMETHASONE VALERATE (Actavis Pharma), BETAMETHASONE VALERATE (Ingenus Pharmaceuticals LLC), BETAMETHASONE VALERATE (Mylan Pharmaceuticals), BETAMETHASONE VALERATE (NuCare Pharmaceuticals), BETAMETHASONE VALERATE (NuCare Pharmaceuticals), BETAMETHASONE VALERATE (Perrigo New York), BETAMETHASONE VALERATE (Preferred Pharmaceuticals), BETAMETHASONE VALERATE (Proficient Rx LP), BETAMETHASONE VALERATE (Proficient Rx LP), BETAMETHASONE VALERATE (REMEDYREPACK), BETAMETHASONE VALERATE (Rebel Distributors Corp), BETAMETHASONE VALERATE (Rebel Distributors Corp.), BETAMETHASONE VALERATE (STI Pharma LLC), BETAMETHASONE VALERATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE VALERATE (Taro Pharmaceuticals U.S.A.)
Formula
C27H37FO6
Exact mass
476.2574
Mol weight
476.5775
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D04773<JP> D04796<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
   Glucocorticoids, High Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
   Glucocorticoids, Very High Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01357  Betamethasone valerate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D01357  Betamethasone valerate (JP17/USP)
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01357  Betamethasone valerate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Betamethasone valerate
    D01357  Betamethasone valerate (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Betamethasone valerate
    D01357  Betamethasone valerate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01357  Betamethasone valerate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01357  Betamethasone valerate
Topical steroids potency [br08317.html]
 Classification in Japan
  D01357
BRITE hierarchy
Other DBs
CAS: 2152-44-5
PubChem: 7848420
ChEBI: 31277
ChEMBL: CHEMBL1497
DrugBank: DB00443
LigandBox: D01357
NIKKAJI: J7.337G
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C     5.4764  -10.5555
            2   C5x C     5.4764  -11.9007
            3   C2x C     6.6413  -12.5733
            4   C2y C     7.8063  -11.9007
            5   C1z C     7.8063  -10.5555
            6   C2x C     6.6413   -9.8830
            7   C1x C     8.9713  -12.5733
            8   C1x C    10.1362  -11.9007
            9   C1y C    10.1362  -10.5555
            10  C1z C     8.9713   -9.8830
            11  C1y C    11.3011   -9.8830
            12  C1z C    11.3011   -8.5378
            13  C1x C    10.1362   -7.8652
            14  C1y C     8.9713   -8.5378
            15  C1x C    13.6310   -9.8830
            16  C1y C    13.6310   -8.5378
            17  C1z C    12.4661   -7.8652
            18  C1a C     7.8063   -9.2103
            19  O1a O     7.8083   -7.8664
            20  C1a C    11.3011   -7.1927
            21  C1a C    14.7836   -7.8722
            22  C5a C    12.4661   -6.1138
            23  X   F     8.9713  -11.2281
            24  O7a O    14.2538   -6.7775
            25  O5x O     4.3116  -12.5733
            26  O5a O    13.6350   -5.4390
            27  C1b C    11.3050   -5.4434
            28  C7a C    15.6379   -6.7775
            29  O6a O    16.3156   -7.9508
            30  C1b C    16.3407   -5.5606
            31  C1b C    17.7063   -5.5610
            32  O1a O    10.0592   -6.1628
            33  C1b C    18.4212   -4.3241
            34  C1a C    19.8099   -4.3249
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Up
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   24  28 1
            32   28  29 2
            33   28  30 1
            34   30  31 1
            35   27  32 1
            36   31  33 1
            37   33  34 1

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