KEGG   DRUG: Roxatidine acetate hydrochloride
Entry
D01467                      Drug                                   

Name
Roxatidine acetate hydrochloride (JP17/USAN);
Altat (TN)
Formula
C19H28N2O4. HCl
Exact mass
384.1816
Mol weight
384.8976
Structure
Simcomp
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Remark
Therapeutic category: 2325
ATC code: A02BA06
Chemical structure group: DG00019
Product (DG00019): D01467<JP>
Efficacy
Anti-ulcerative, H2 receptor antagonist
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Interaction
Structure map
map07038  Antiulcer drugs
map07227  Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA06 Roxatidine
      D01467  Roxatidine acetate hydrochloride (JP17/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D01467  Roxatidine acetate hydrochloride (JP17/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D01467  Roxatidine acetate hydrochloride (JP17/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Roxatidine acetate hydrochloride
    D01467  Roxatidine acetate hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D01467  Roxatidine acetate hydrochloride (JP17/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01467  Roxatidine acetate hydrochloride
  D01467  Roxatidine acetate hydrochloride extended-release tablets
  D01467  Roxatidine acetate hydrochloride extended-release capsules
  D01467  Roxatidine acetate hydrochloride for injection
Rx-to-OTC switch list in Japan [br08314.html]
 D01467
Other DBs
CAS: 93793-83-0
PubChem: 7848530
ChEBI: 32107
ChEMBL: CHEMBL2104871
LigandBox: D01467
NIKKAJI: J245.458K
LinkDB
KCF data

ATOM        26
            1   N1b N    27.4400  -22.4000
            2   C8x C    18.9700  -20.3000
            3   C8y C    18.9700  -21.7000
            4   C8x C    20.2300  -22.4000
            5   C8y C    21.4200  -21.7000
            6   C8x C    21.4200  -20.3000
            7   C8x C    20.2300  -19.6000
            8   O2a O    22.6800  -22.4000
            9   C1b C    23.8700  -21.7000
            10  C1b C    25.0600  -22.4000
            11  C1b C    26.1800  -21.7000
            12  C1b C    17.7800  -22.4000
            13  N1y N    16.5900  -21.7000
            14  C1x C    16.5900  -20.3000
            15  C1x C    15.4000  -19.6000
            16  C1x C    14.1400  -20.3000
            17  C1x C    14.1400  -21.7000
            18  C1x C    15.3300  -22.4000
            19  C5a C    28.6300  -21.7000
            20  C1b C    29.8200  -22.4000
            21  O7a O    31.0100  -21.7000
            22  C7a C    32.2000  -22.4000
            23  C1a C    33.4600  -21.7000
            24  O5a O    28.6300  -20.3000
            25  O6a O    32.2000  -23.8000
            26  X   Cl   30.1700  -25.4800
BOND        26
            1     6   7 2
            2     7   2 1
            3    13  18 1
            4    14  15 1
            5    15  16 1
            6    16  17 1
            7    17  18 1
            8     8   9 1
            9     9  10 1
            10    2   3 2
            11   10  11 1
            12   11   1 1
            13    8   5 1
            14    1  19 1
            15   19  20 1
            16    3   4 1
            17   20  21 1
            18    3  12 1
            19   21  22 1
            20    4   5 2
            21   22  23 1
            22   12  13 1
            23   19  24 2
            24   13  14 1
            25   22  25 2
            26    5   6 1

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