KEGG   DRUG: Alfuzosin hydrochlorideHelp
Entry
D01692                      Drug                                   

Name
Alfuzosin hydrochloride (JAN/USAN);
Uroxatral (TN)
Product
  Generic
Formula
C19H27N5O4. HCl
Exact mass
425.183
Mol weight
425.9097
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: G04CA01
Chemical structure group: DG00489
Product (DG00489): D01692<US>
Efficacy
Antidysuria, Antihypertensive, alpha1-Adrenergic receptor antagonist
Comment
Prazosin derivative
Target
ADRA1A [HSA:148] [KO:K04135]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA01 Alfuzosin
      D01692  Alfuzosin hydrochloride (JAN/USAN) <US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Alfuzosin
    D01692  Alfuzosin hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1A
     D01692  Alfuzosin hydrochloride (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01692
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01692
BRITE hierarchy
Other DBs
CAS: 81403-68-1
PubChem: 7848755
ChEBI: 32286
ChEMBL: CHEMBL1723
DrugBank: DB00346
LigandBox: D01692
NIKKAJI: J346.511J
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8y C    21.4500  -13.4748
            2   C8y C    21.4500  -12.0658
            3   C8x C    22.6778  -14.1822
            4   C8y C    20.2397  -14.1822
            5   N5x N    20.2397  -11.3817
            6   C8x C    22.6778  -11.3817
            7   C8y C    23.8821  -13.4748
            8   N5x N    19.0294  -13.4748
            9   N1a N    20.2397  -15.5855
            10  C8y C    19.0294  -12.0658
            11  C8y C    23.8821  -12.0658
            12  O2a O    25.1158  -14.1822
            13  N1c N    17.8190  -11.3817
            14  O2a O    25.1158  -11.3817
            15  C1a C    26.3203  -13.4689
            16  C1b C    16.5970  -12.0658
            17  C1a C    26.3203  -12.0774
            18  C1a C    17.8219   -9.9828
            19  C1b C    15.3948  -11.3505
            20  C1b C    14.1744  -12.0339
            21  N1b N    12.9722  -11.3186
            22  C5a C    11.7517  -12.0019
            23  O5a O    11.7799  -13.4006
            24  C1y C    10.5565  -11.3311
            25  C1x C    10.1211  -10.0016
            26  O2x O     9.4217  -12.1564
            27  C1x C     8.2870  -11.3311
            28  C1x C     8.7223  -10.0016
            29  X   Cl   29.5439  -12.6330
BOND        30
            1     7  12 1
            2    10  13 1
            3    11  14 1
            4    12  15 1
            5    13  16 1
            6    14  17 1
            7     7  11 1
            8     8  10 1
            9    13  18 1
            10   16  19 1
            11    1   2 2
            12   19  20 1
            13    1   3 1
            14   20  21 1
            15    1   4 1
            16   21  22 1
            17    2   5 1
            18   22  23 2
            19    2   6 1
            20   22  24 1
            21    3   7 2
            22    4   8 2
            23    4   9 1
            24    5  10 2
            25   25  24 1
            26   24  26 1
            27   26  27 1
            28   27  28 1
            29   28  25 1
            30    6  11 2

» Japanese version   » Back

DBGET integrated database retrieval system