KEGG   DRUG: Lidocaine hydrochloride
Entry
D02086                      Drug                                   

Name
Lidocaine hydrochloride (JAN/USP);
Dalcaine (TN);
Xylocaine (TN)
Product
  Generic
LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE (A-S Medication Solutions), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE (Akorn), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (B. Braun Medical), LIDOCAINE HYDROCHLORIDE (Bryant Ranch Prepack), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Civica), LIDOCAINE HYDROCHLORIDE (DIRECT RX), LIDOCAINE HYDROCHLORIDE (DIRECT RX), LIDOCAINE (Fresenius Kabi USA), LIDOCAINE (Fresenius Kabi USA), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (Hi-Tech Pharmacal), LIDOCAINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), LIDOCAINE (Hikma Pharmaceuticals USA), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Huons), PRELIDOPINE PRE-OPERATIVE SYSTEM (IT3 Medical LLC), DX1 ORAGENOMIC MEDICATED DNA COLLECTION SCREEN (IT3 Medical LLC), SX1 MEDICATED POST-OPERATIVE SYSTEM (IT3 Medical LLC), VENIPUNCTURE PX1 (IT3 Medical LLC), DX2 ORAGENOMIC MEDICATED DNA COLLECTION SCREEN (IT3 Medical LLC), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (Lannett Company), LIDOCAINE HYDROCHLORIDE (Lannett Company), LIDOCAINE HYDROCHLORIDE (McKesson Corporation), LIDOCAINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE (Medical Purchasing Solutions), LIDOCAINE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (NuCare Pharmaceuticals), LIDOCAINE VISCOUS (Pharmaceutical Associates), LIDOCAINE HYDROCHLORIDE (Preferred Pharmaceuticals), LIDOCAINE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), GLYDO (Sagent Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Teligent Pharma), READYSHARP LIDOCAINE (Terrain Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp), LIDOCAINE VISCOUS (West-Ward Pharmaceuticals Corp.), LIDOCAINE HYDROCHLORIDE (Spectra Medical Devices)
Formula
C14H22N2O. HCl
Exact mass
270.1499
Mol weight
270.7982
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1214 1313 2129
ATC code: C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01
Chemical structure group: DG00196
Product (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP/US>
Product (mixture): D04052<JP/US> D04813<JP/US>
Efficacy
Anesthetic (local), Antiarrhythmic, Sodium channel blocker
Comment
Anilide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D02086  Lidocaine hydrochloride (JAN/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1313  Ophthalmic local anesthetics
     D02086  Lidocaine hydrochloride (JAN/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D02086  Lidocaine hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D02086  Lidocaine hydrochloride (JAN/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02086  Lidocaine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN2A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN3A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN4A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN5A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN8A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN9A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN10A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN11A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02086
Other DBs
CAS: 73-78-9
PubChem: 7849147
ChEBI: 50512
ChEMBL: CHEMBL541521
DrugBank: DB00281
LigandBox: D02086
NIKKAJI: J231.458D J5.631F
LinkDB
KCF data

ATOM        18
            1   C8y C    27.4132  -17.1509
            2   N1b N    28.6465  -17.8641
            3   C8y C    26.1855  -17.8699
            4   C8y C    27.4132  -15.7304
            5   C5a C    29.8742  -17.1450
            6   C8x C    24.9579  -17.1509
            7   C1a C    26.1914  -19.2846
            8   C8x C    26.1855  -15.0230
            9   C1a C    28.6348  -15.0230
            10  C1b C    31.1017  -17.8641
            11  O5a O    29.9091  -16.0694
            12  C8x C    24.9579  -15.7304
            13  N1c N    32.3352  -17.1450
            14  C1b C    33.5686  -17.8641
            15  C1b C    32.3352  -15.7304
            16  C1a C    34.7845  -17.1450
            17  C1a C    33.5686  -15.0172
            18  X   Cl   39.1297  -16.5898
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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