KEGG   DRUG: Azithromycin hydrateHelp
Entry
D02134                      Drug                                   

Name
Azithromycin hydrate (JP17);
Azithromycin dihydrate;
Zithromac (TN);
Zmax (TN);
Azimycin (TN)
Product
  Generic
AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN (A-S Medication Solutions), AZITHROMYCIN (Aurobindo Pharma Limited), AZITHROMYCIN (Aurobindo Pharma Limited), AZITHROMYCIN (Bionpharma), AZITHROMYCIN (Bionpharma), AZITHROMYCIN (Bryant Ranch Prepack), AZITHROMYCIN (Bryant Ranch Prepack), AZITHROMYCIN (Bryant Ranch Prepack), AZITHROMYCIN (Bryant Ranch Prepack), AZITHROMYCIN (Bryant Ranch Prepack), AZITHROMYCIN (Cadila Healthcare Limited), AZITHROMYCIN DIHYDRATE (Cambridge Therapeutics Technologies), AZITHROMYCIN (Central Texas Community Health Centers), AZITHROMYCIN (Central Texas Community Health Centers), AZITHROMYCIN (Central Texas Community Health Centers), AZITHROMYCIN (Central Texas Community Health Centers), AZITHROMYCIN (Central Texas Community Health Centers), AZITHROMYCIN (Direct_Rx), AZITHROMYCIN (Greenstone LLC), AZITHROMYCIN (Lake Erie Medical DBA Quality Care Products LLC), AZITHROMYCIN DIHYDRATE (Major Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Medsource Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (NuCare Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN DIHYDRATE (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN DIHYDRATE (RPK Pharmaceuticals), AZITHROMYCIN DIHYDRATE (Unit Dose Services), AZITHROMYCIN (Zydus Pharmaceuticals (USA)), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN DIHYDRATE (A-S Medication Solutions), AZITHROMYCIN (Slate Run Pharmaceuticals), AZITHROMYCIN DIHYDRATE (TAGI Pharma), AZITHROMYCIN DIHYDRATE (TAGI Pharma), AZITHROMYCIN DIHYDRATE (TAGI Pharma)
Formula
C38H72N2O12. 2H2O
Exact mass
784.5297
Mol weight
785.015
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01875  15-Membered ring macrolide antibiotic
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
Therapeutic category: 6149
ATC code: J01FA10 S01AA26
Chemical structure group: DG00606
Product (DG00606): D07486<US> D02134<JP/US> D06390<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Urethritis due to Chlamydia trachomatis [DS:H00347]
Disseminated Mycobacterium avium complex (MAC) disease [DS:H01458]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D02134  Azithromycin hydrate (JP17) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA26 Azithromycin
      D02134  Azithromycin hydrate (JP17) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D02134  Azithromycin hydrate (JP17)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Azithromycin
     D02134  Azithromycin hydrate (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6149  Others
     D02134  Azithromycin hydrate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02134  Azithromycin hydrate
Antiinfectives [br08350.html]
 Antibacterials
  D02134
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02134
BRITE hierarchy
Other DBs
CAS: 117772-70-0
PubChem: 7849195
ChEBI: 34546
DrugBank: DB00207
LigandBox: D02134
NIKKAJI: J1.893.284I
LinkDB All DBs
KCF data Show

ATOM        54
            1   C1y C    24.7580  -16.6914
            2   C1y C    23.5463  -17.3176
            3   O2a O    26.3209  -17.6570
            4   C1z C    24.8046  -15.3624
            5   C1y C    23.5462  -18.6405
            6   C1a C    22.7374  -16.2886
            7   C1y C    27.6732  -16.8903
            8   C1x C    24.0087  -14.7889
            9   C1a C    25.9698  -15.9186
            10  O1a O    25.9815  -14.6425
            11  O2a O    24.2837  -20.5664
            12  C1y C    22.3930  -19.2846
            13  C1y C    28.3990  -18.1312
            14  O2x O    28.3873  -15.6375
            15  C1y C    24.4887  -13.5242
            16  C1y C    25.8876  -21.2806
            17  C7x C    21.2690  -18.5879
            18  C1a C    22.3637  -20.6075
            19  C1y C    29.8333  -18.1195
            20  O1a O    27.6849  -19.3841
            21  C1y C    29.8273  -15.6375
            22  C1x C    23.6926  -12.7049
            23  C1a C    25.5074  -12.9684
            24  C1x C    25.8876  -22.7265
            25  O2x O    27.1289  -20.5664
            26  O7x O    21.2925  -17.2650
            27  O6a O    20.3146  -19.5655
            28  C1x C    30.5415  -16.8786
            29  N1c N    30.5532  -19.3664
            30  C1a C    30.5415  -14.3907
            31  N1y N    22.4751  -12.6639
            32  C1z C    27.1289  -23.4407
            33  C1y C    28.3755  -21.2806
            34  C1y C    20.1627  -16.5917
            35  C1a C    31.9173  -20.2738
            36  C1a C    31.8469  -18.6699
            37  C1y C    21.3219  -13.2902
            38  C1a C    22.5041  -11.2941
            39  C1y C    28.3755  -22.7265
            40  O2a O    27.1172  -24.7754
            41  C1a C    29.6166  -20.5664
            42  C1z C    20.1511  -15.2630
            43  C1b C    19.0038  -17.2124
            44  C1y C    21.3160  -14.6308
            45  C1a C    20.1628  -12.6112
            46  O1a O    29.6166  -23.4407
            47  C1a C    28.2703  -25.4544
            48  C1a C    18.8634  -15.7723
            49  O1a O    19.0038  -14.1742
            50  C1a C    18.9744  -18.5410
            51  O1a O    22.4633  -15.3039
            52  C1a C    25.9163  -24.1408
            53  O0  O    35.0000  -23.3800
            54  O0  O    35.0000  -23.3800
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up
BRACKET     1    33.1100  -24.4300   33.1100  -22.4700
            1    35.4200  -22.4700   35.4200  -24.4300
            1  2
 ORIGINAL  1   53
 REPEAT    1   54

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