KEGG   DRUG: Galantamine hydrobromideHelp
Entry
D02173                      Drug                                   

Name
Galantamine hydrobromide (JAN/USP);
Razadyne (TN);
Reminyl (TN)
Product
  Generic
Formula
C17H21NO3. HBr
Exact mass
367.0783
Mol weight
368.2655
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01968  Agents for Alzheimer-type dementia
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1190
ATC code: N06DA04
Chemical structure group: DG00985
Product (DG00985): D02173<JP/US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
  Disease
Dementia of the Alzheimer's type [DS:H00056]
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA04 Galantamine
      D02173  Galantamine hydrobromide (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Galantamine
    D02173  Galantamine hydrobromide (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02173  Galantamine hydrobromide (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D02173  Galantamine hydrobromide (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02173
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02173
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02173
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02173
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02173
BRITE hierarchy
Other DBs
CAS: 1953-04-4
PubChem: 7849234
ChEMBL: CHEMBL1555 CHEMBL1555821
DrugBank: DB00674
LigandBox: D02173
NIKKAJI: J220.074K
LinkDB All DBs
KCF data Show

ATOM        22
            1   X   Br   26.7123  -22.0590
            2   C8y C    21.3562  -22.9628
            3   C1x C    22.4064  -23.7330
            4   N1y N    23.7367  -23.4529
            5   C1x C    24.2969  -22.1927
            6   C8y C    21.3562  -21.5625
            7   C1x C    23.7367  -21.0024
            8   C1z C    22.4064  -20.5123
            9   C1a C    24.6470  -24.5032
            10  C8x C    20.1659  -23.6630
            11  C8x C    18.9756  -22.9628
            12  C8y C    18.9756  -21.5625
            13  C8y C    20.1659  -20.8623
            14  O2a O    17.7854  -20.9324
            15  O2x O    20.5160  -19.2520
            16  C1y C    21.9163  -19.1820
            17  C1x C    22.5465  -18.0617
            18  C1y C    23.9468  -18.0617
            19  C2x C    24.6470  -19.2520
            20  C2x C    23.9468  -20.5123
            21  O1a O    24.6470  -16.8014
            22  C1a C    16.5992  -21.6765
BOND        24
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     8   7 1 #Down
            8     4   9 1
            9     2  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13    6  13 1
            14   12  14 1
            15   13  15 1
            16   15  16 1
            17    8  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21    8  20 1
            22   20  19 2
            23   18  21 1 #Up
            24   14  22 1

» Japanese version   » Back

KEGG   DRUG: GalantamineHelp
Entry
D04292                      Drug                                   

Name
Galantamine (USAN/INN);
Reminyl (TN)
Formula
C17H21NO3
Exact mass
287.1521
Mol weight
287.3535
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Source
Galanthus woronowii [TAX:197699]
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01968  Agents for Alzheimer-type dementia
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C08526
ATC code: N06DA04
Chemical structure group: DG00985
Product (DG00985): D02173<JP/US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
Comment
Galanthus alkaloid
Alzheimer's disease treatment
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA04 Galantamine
      D04292  Galantamine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D04292  Galantamine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04292
BRITE hierarchy
Other DBs
CAS: 357-70-0
PubChem: 47206224
ChEBI: 42944
ChEMBL: CHEMBL1624158 CHEMBL659
DrugBank: DB00674
PDB-CCD: GNT[PDBj]
LigandBox: D04292
NIKKAJI: J11.407C
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    26.6000  -12.1800
            2   C1x C    27.6500  -12.9500
            3   N1y N    28.9800  -12.6700
            4   C1x C    29.5400  -11.4100
            5   C8y C    26.6000  -10.7800
            6   C1x C    28.9800  -10.2200
            7   C1z C    27.6500   -9.7300
            8   C1a C    29.8900  -13.7200
            9   C8x C    25.4100  -12.8800
            10  C8x C    24.2200  -12.1800
            11  C8y C    24.2200  -10.7800
            12  C8y C    25.4100  -10.0800
            13  O2a O    23.0300  -10.1500
            14  O2x O    25.7600   -8.4700
            15  C1y C    27.1600   -8.4000
            16  C1x C    27.7900   -7.2800
            17  C1y C    29.1900   -7.2800
            18  C2x C    29.8900   -8.4700
            19  C2x C    29.1900   -9.7300
            20  O1a O    29.8900   -6.0200
            21  C1a C    21.8441  -10.8940
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     7   6 1 #Down
            8     3   8 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    5  12 1
            14   11  13 1
            15   12  14 1
            16   14  15 1
            17    7  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21    7  19 1
            22   19  18 2
            23   17  20 1 #Up
            24   13  21 1

» Japanese version   » Back

DBGET integrated database retrieval system