KEGG   DRUG: Pilocarpine hydrochloride
Entry
D02200                      Drug                                   

Name
Pilocarpine hydrochloride (JP17/USP);
Isopto carpine (TN);
Pilopine HS (TN);
Salagen (TN);
Sanpilo (TN)
Product
  Generic
Formula
C11H16N2O2. HCl
Exact mass
244.0979
Mol weight
244.7179
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
Therapeutic category: 1312 2399
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Antiglaucoma, Miotic, Salivation accelaletor, Muscarinic acetylcholine receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Sjogren's Syndrome [DS:H01502]
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D02200  Pilocarpine hydrochloride (JP17/USP)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Cholinergic Agonists, Ophthalmic
    Pilocarpine
     D02200  Pilocarpine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D02200  Pilocarpine hydrochloride (JP17/USP)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02200  Pilocarpine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D02200  Pilocarpine hydrochloride (JP17/USP) <JP/US>
    CHRM3
     D02200  Pilocarpine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02200  Pilocarpine hydrochloride
  D02200  Pilocarpine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02200
Other DBs
CAS: 54-71-7
PubChem: 7849260
ChEMBL: CHEMBL1200330
DrugBank: DB01085
LigandBox: D02200
NIKKAJI: J231.249B
LinkDB
KCF data

ATOM        16
            1   C1y C    22.9454  -19.7221
            2   C1y C    21.4986  -19.7221
            3   C1b C    24.1589  -20.3289
            4   C1x C    23.3654  -18.3687
            5   C7x C    21.0786  -18.3687
            6   C1b C    20.7052  -20.8422
            7   C8y C    25.2323  -19.7221
            8   O7x O    22.2454  -17.5286
            9   O6a O    19.7251  -17.9019
            10  C1a C    19.3051  -20.8422
            11  N4y N    26.6324  -19.7221
            12  C8x C    24.7656  -18.3687
            13  C8x C    27.0525  -18.3687
            14  C1a C    27.4725  -20.8422
            15  N5x N    25.9323  -17.5286
            16  X   Cl   29.8072  -18.8353
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

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