| Entry |
|
|---|
| Name |
Alvimopan (USAN);
Alvimopan dihydrate;
Entereg (TN)
|
|---|
| Product |
|
|---|
| Formula |
C25H32N2O4. 2H2O
|
|---|
| Exact mass |
460.2573
|
|---|
| Mol weight |
460.5631
|
|---|
| Structure |
   |
|---|
| Class |
Gastrointestinal agent
DG01770 Laxative
DG01768 Opioid-induced laxative
Analgesic
DG01586 Opioid receptor antagonist
|
|---|
| Remark |
|
|---|
| Efficacy |
Laxative, Opioid receptor antagonist |
|---|
| Comment |
Treatment of opioid-induced bowel dysfunction, opioid-induced nausea and vomiting, postoperative ileus, idiopathic constipation, and irritable bowel syndrome
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A06 DRUGS FOR CONSTIPATION
A06A DRUGS FOR CONSTIPATION
A06AH Peripheral opioid receptor antagonist
A06AH02 Alvimopan
D02878 Alvimopan (USAN) <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Gastrointestinal Agents, Other
Alvimopan
D02878 Alvimopan (USAN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D02878 Alvimopan (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02878
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02878
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 O0 O 38.7802 -16.8251
2 C1z C 23.1358 -16.4305
3 C1y C 23.1358 -17.8140
4 C1x C 24.3339 -18.5057
5 N1y N 25.5321 -17.8140
6 C1x C 25.5321 -16.4305
7 C1x C 24.3339 -15.7387
8 C1a C 21.9377 -18.5057
9 C1b C 26.7302 -18.5057
10 C1c C 27.9283 -17.8140
11 C1b C 27.9283 -16.4305
12 C5a C 29.1265 -18.5057
13 N1b N 30.3246 -17.8140
14 C1b C 31.5228 -18.5057
15 C6a C 32.7210 -17.8140
16 O5a O 29.1265 -19.8892
17 O6a O 33.9191 -18.5057
18 O6a O 32.7210 -16.4305
19 C8x C 30.3246 -16.4305
20 C8y C 29.1264 -15.7387
21 C8x C 31.5228 -15.7387
22 C8x C 31.5228 -14.3552
23 C8x C 30.3245 -13.6635
24 C8x C 29.1264 -14.3552
25 C8y C 21.9574 -15.7502
26 C8x C 21.9574 -14.3502
27 C8x C 20.7450 -13.6502
28 C8x C 19.5325 -14.3502
29 C8y C 19.5326 -15.7503
30 C8x C 20.7450 -16.4502
31 O1a O 18.3183 -16.4513
32 C1a C 23.1358 -15.0305
33 O0 O 38.7802 -16.8251
BOND 33
1 2 3 1
2 3 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 2 7 1
7 3 8 1 #Down
8 5 9 1
9 9 10 1
10 10 12 1
11 12 13 1
12 13 14 1
13 14 15 1
14 10 11 1 #Down
15 12 16 2
16 15 17 1
17 15 18 2
18 20 11 1
19 20 19 2
20 19 21 1
21 21 22 2
22 22 23 1
23 23 24 2
24 20 24 1
25 2 25 1
26 25 26 2
27 26 27 1
28 27 28 2
29 28 29 1
30 29 30 2
31 25 30 1
32 29 31 1
33 2 32 1 #Up
BRACKET 1 36.5400 -17.6400 36.5400 -16.1000
1 39.6200 -16.1000 39.6200 -17.6400
1 2
ORIGINAL 1 1
REPEAT 1 33
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