KEGG   DRUG: Vardenafil hydrochloride hydrateHelp
Entry
D03260                      Drug                                   

Name
Vardenafil hydrochloride hydrate (JAN);
Levitra (TN);
Staxyn (TN)
Product
  Generic
Formula
C23H32N6O4S. 3H2O. HCl
Exact mass
578.2289
Mol weight
579.1098
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01509  Phosphodiesterase V inhibitor
Remark
Therapeutic category: 2590
ATC code: G04BE09
Chemical structure group: DG00487
Product (DG00487): D03260<JP/US>
Efficacy
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor
Comment
Treatment of erectile dysfunction
Target
PDE5 [HSA:8654] [KO:K13762]
  Pathway
hsa04022  cGMP-PKG signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE09 Vardenafil
      D03260  Vardenafil hydrochloride hydrate (JAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D03260  Vardenafil hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE5
     D03260  Vardenafil hydrochloride hydrate (JAN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D03260
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03260
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03260
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03260
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03260
BRITE hierarchy
Other DBs
PubChem: 17397413
DrugBank: DB00862
LigandBox: D03260
LinkDB All DBs
KCF data Show

ATOM        38
            1   C8y C    20.3016  -19.5044
            2   C8y C    21.4944  -18.8028
            3   C8y C    20.3016  -20.9076
            4   C8x C    19.0388  -18.8028
            5   N4x N    22.6871  -19.5044
            6   N5x N    21.4944  -17.3996
            7   C8x C    19.0388  -21.6092
            8   O2a O    21.4944  -21.6092
            9   C8y C    17.8460  -19.5044
            10  N4y N    23.9500  -18.8028
            11  C8y C    22.6871  -16.6980
            12  C8x C    17.8460  -20.9076
            13  C1b C    22.6871  -20.9076
            14  S4a S    16.6533  -18.8028
            15  C8y C    23.9500  -17.3996
            16  C8y C    25.2830  -19.2238
            17  O5x O    22.6871  -15.2948
            18  C1a C    23.8798  -21.6092
            19  N1y N    15.4606  -19.5044
            20  O3c O    17.6356  -17.8206
            21  O3c O    15.6711  -17.8206
            22  C8y C    25.2830  -16.9786
            23  N5x N    26.1249  -18.1012
            24  C1b C    25.7040  -20.5568
            25  C1x C    15.4606  -20.9076
            26  C1x C    14.1977  -18.8028
            27  C1a C    25.7040  -15.6456
            28  C1b C    27.0370  -20.8374
            29  C1x C    14.1977  -21.6092
            30  C1x C    13.0050  -19.5044
            31  C1a C    27.4580  -22.1705
            32  N1y N    13.0050  -20.9076
            33  C1b C    11.8123  -21.6092
            34  C1a C    10.6195  -20.9076
            35  X   Cl   31.4575  -17.6833
            36  O0  O    31.6109  -19.7833
            37  O0  O    31.6109  -19.7833
            38  O0  O    31.6109  -19.7833
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   11  17 2
            17   13  18 1
            18   14  19 1
            19   14  20 2
            20   14  21 2
            21   15  22 2
            22   16  23 2
            23   16  24 1
            24   19  25 1
            25   19  26 1
            26   22  27 1
            27   24  28 1
            28   25  29 1
            29   26  30 1
            30   28  31 1
            31   29  32 1
            32   32  33 1
            33    9  12 2
            34   11  15 1
            35   22  23 1
            36   30  32 1
            37   33  34 1
BRACKET     1    29.3300  -20.6500   29.3300  -19.0400
            1    32.2700  -19.0400   32.2700  -20.6500
            1  3
 ORIGINAL  1   36
 REPEAT    1   37  38

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