KEGG   DRUG: Diethylpropion hydrochlorideHelp
Entry
D03801                      Drug                                   

Name
Diethylpropion hydrochloride (USP);
Tenuate (TN)
Product
  Generic
DIETHYLPROPION HYDROCHLORIDE (A-S Medication Solutions), DIETHYLPROPION HYDROCHLORIDE (A-S Medication Solutions), DIETHYLPROPION HYDROCHLORIDEER (Aidarex Pharmaceuticals LLC), DIETHYLPROPION HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DIETHYLPROPION HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DIETHYLPROPION HYDROCHLORIDE (Bryant Ranch Prepack), DIETHYLPROPION HYDROCHLORIDE (Bryant Ranch Prepack), DIETHYLPROPION HYDROCHLORIDE (Bryant Ranch Prepack), DIETHYLPROPION HYDROCHLORIDE (CALVIN), DIETHYLPROPION HYDROCHLORIDE (H.J. Harkins Company), DIETHYLPROPION HYDROCHLORIDE (KVK-TECH), DIETHYLPROPION HYDROCHLORIDE (Lannett Company), DIETHYLPROPION HYDROCHLORIDE (Lannett Company), DIETHYLPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), DIETHYLPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), DIETHYLPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), DIETHYLPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), DIETHYLPROPION HYDROCHLORIDE (Proficient Rx LP), DIETHYLPROPION HYDROCHLORIDE (Proficient Rx LP), DIETHYLPROPION HYDROCHLORIDE (Unit Dose Services)
Formula
C13H19NO. HCl
Exact mass
241.1233
Mol weight
241.757
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01706  Antiobesity
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
Remark
ATC code: A08AA03
Chemical structure group: DG00104
Product (DG00104): D03801<US>
Efficacy
Appetite suppressant
Comment
Diethylpropion is called Amfepramone in INN.
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA03 Amfepramone
      D03801  Diethylpropion hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Anti-Obesity Agents
  Diethylpropion
   D03801  Diethylpropion hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D03801  Diethylpropion hydrochloride (USP) <US>
    SLC6A3 (DAT1)
     D03801  Diethylpropion hydrochloride (USP) <US>
BRITE hierarchy
Other DBs
CAS: 134-80-5
PubChem: 17397889
ChEBI: 643703
ChEMBL: CHEMBL1693
DrugBank: DB00937
LigandBox: D03801
NIKKAJI: J472.997H
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8y C    11.2700  -16.5200
            2   C5a C    12.4600  -15.8200
            3   C8x C    10.0800  -15.8200
            4   C8x C    11.2700  -17.9200
            5   C1c C    13.7200  -16.5200
            6   O5a O    12.4600  -14.4200
            7   C8x C     8.8200  -16.5200
            8   C8x C    10.0800  -18.6200
            9   N1c N    14.9100  -15.8200
            10  C1a C    13.7200  -17.9200
            11  C8x C     8.8200  -17.9200
            12  C1b C    16.1000  -16.5200
            13  C1b C    14.9100  -14.4200
            14  C1a C    17.3600  -15.8200
            15  C1a C    16.1000  -13.7200
            16  X   Cl   18.1300  -18.4800
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    8  11 1

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