KEGG   DRUG: Paliperidone
Entry
D05339                      Drug                                   
Name
Paliperidone (JAN/USP/INN);
Invega (TN)
Product
INVEGA (Janssen Pharmaceuticals)
  Generic
PALIPERIDONE (ANI Pharmaceuticals), PALIPERIDONE (Actavis Pharma), PALIPERIDONE (American Health Packaging), PALIPERIDONE (Amneal Pharmaceuticals LLC), PALIPERIDONE (Archis Pharma LLC), PALIPERIDONE (Ascent Pharmaceuticals), PALIPERIDONE (AvKARE), PALIPERIDONE (Camber Pharmaceuticals), PALIPERIDONE (Lupin Pharmaceuticals), PALIPERIDONE (Major Pharmaceuticals), PALIPERIDONE (Mylan Pharmaceuticals), PALIPERIDONE (NorthStar RxLLC), PALIPERIDONE (Patriot Pharmaceuticals), PALIPERIDONE (REMEDYREPACK), PALIPERIDONE (REMEDYREPACK), PALIPERIDONE (Sun Pharmaceutical Industries), PALIPERIDONE (Tris Pharma)
Formula
C23H27FN4O3
Exact mass
426.2067
Mol weight
426.4839
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03005  Serotonin-dopamine antagonist (SDA)
 DG03200  Antipsychotic agent
  DG03064  Atypical antipsychotic
Remark
Same as: C21516
Therapeutic category: 1179
ATC code: N05AX13
Chemical structure group: DG00907
Product (DG00907): D05339<JP/US> D05340<JP/US>
Efficacy
Antipsychotic, Serotonin receptor antagonist, Dopamine D2 receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Comment
Serotonin-dopamine antagonists (SDA)
Risperidone derivative
Treatment of schizophrenia
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX13 Paliperidone
      D05339  Paliperidone (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Paliperidone
    D05339  Paliperidone (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D05339  Paliperidone (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00907  Paliperidone
     D05339  Paliperidone
  DG03005  Serotonin-dopamine antagonist (SDA)
   DG00907  Paliperidone
    D05339  Paliperidone
  DG03200  Antipsychotic agent
   DG03064  Atypical antipsychotic
    DG00907  Paliperidone
     D05339  Paliperidone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D05339  Paliperidone (JAN/USP/INN) <JP/US>
   Serotonin
    HTR2A
     D05339  Paliperidone (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05339
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05339
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05339
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05339
Prodrugs [br08324.html]
 D05339
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00907  Paliperidone
  DG03005  Serotonin-dopamine antagonist (SDA)
   DG00907  Paliperidone
  DG03200  Antipsychotic agent
   DG03064  Atypical antipsychotic
    DG00907  Paliperidone
Prodrugs [br08324.html]
 DG00907
Other DBs
CAS: 144598-75-4
PubChem: 47207025
ChEBI: 82978
LigandBox: D05339
NIKKAJI: J508.304D
LinkDB
KCF data

ATOM        31
            1   C8y C    20.0200  -19.1800
            2   C8y C    20.0200  -17.7800
            3   N5x N    21.2100  -17.0800
            4   C8y C    22.4700  -17.7800
            5   N4y N    22.4700  -19.1800
            6   C8y C    21.2100  -19.8800
            7   C1y C    23.6600  -17.0800
            8   C1x C    24.8500  -17.7800
            9   C1x C    24.8500  -19.1800
            10  C1x C    23.6600  -19.8800
            11  O1a O    23.6600  -15.6800
            12  C1a C    18.8300  -17.0800
            13  O5x O    21.2100  -21.2800
            14  C1b C    18.8300  -19.8800
            15  C1b C    17.6400  -19.1800
            16  N1y N    16.4500  -19.8800
            17  C1x C    16.4500  -21.2800
            18  C1x C    15.2600  -21.9800
            19  C1y C    14.0700  -21.2800
            20  C1x C    14.0700  -19.8800
            21  C1x C    15.2600  -19.1800
            22  C8y C    12.8100  -21.9800
            23  N5x N    11.6753  -21.1600
            24  O2x O    10.5448  -21.9858
            25  C8y C    10.9808  -23.3162
            26  C8y C    12.3808  -23.3126
            27  C8x C    10.2839  -24.5304
            28  C8y C    10.9870  -25.7410
            29  C8x C    12.3870  -25.7375
            30  C8x C    13.0839  -24.5232
            31  X   F    10.2826  -26.9681
BOND        35
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    7  11 1
            13    2  12 1
            14    6  13 2
            15    1  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1
            24   19  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   22  26 1
            30   25  27 2
            31   27  28 1
            32   28  29 2
            33   29  30 1
            34   26  30 2
            35   28  31 1

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