KEGG   DRUG: AlfentanilHelp
Entry
D07122                      Drug                                   

Name
Alfentanil (INN);
Rapifen (TN)
Formula
C21H32N6O3
Exact mass
416.2536
Mol weight
416.5172
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Remark
Same as: C08005
ATC code: N01AH02
Chemical structure group: DG00792
Product (DG00792): D00835<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
synthetic opioid
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH02 Alfentanil
      D07122  Alfentanil (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07122  Alfentanil (INN)
BRITE hierarchy
Other DBs
CAS: 71195-58-9
PubChem: 51091461
ChEBI: 2569
ChEMBL: CHEMBL634
DrugBank: DB00802
LigandBox: D07122
NIKKAJI: J330.279B
LinkDB All DBs
KCF data Show

ATOM        30
            1   C8x C    17.1500  -27.4400
            2   C8x C    17.1500  -28.8400
            3   C8x C    18.3400  -29.5400
            4   C8x C    19.6000  -28.8400
            5   C8y C    19.6000  -27.4400
            6   C8x C    18.3400  -26.7400
            7   N1c N    20.7900  -26.7400
            8   C1z C    22.0500  -27.4400
            9   C1x C    22.0500  -28.8400
            10  C1x C    23.2400  -29.5400
            11  N1y N    24.4300  -28.8400
            12  C1x C    24.4300  -27.4400
            13  C1x C    23.2400  -26.7400
            14  C1b C    25.6900  -29.5400
            15  C1b C    26.8800  -28.8400
            16  N4y N    28.0700  -29.5400
            17  N5x N    28.4200  -30.8700
            18  N5x N    29.8200  -30.8700
            19  N4y N    30.3100  -29.6100
            20  C8y C    29.1900  -28.7700
            21  C5a C    20.7900  -25.3400
            22  O5a O    19.6000  -24.6400
            23  C1b C    22.0500  -24.6400
            24  C1a C    23.2400  -25.3400
            25  C1b C    20.7900  -28.1400
            26  O2a O    20.7900  -29.5400
            27  C1a C    19.6000  -30.2400
            28  O5x O    29.1900  -27.3700
            29  C1b C    31.5000  -28.9100
            30  C1a C    32.6900  -29.6100
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 1
            22   16  20 1
            23    7  21 1
            24   21  22 2
            25   21  23 1
            26   23  24 1
            27    8  25 1
            28   25  26 1
            29   26  27 1
            30   20  28 2
            31   29  30 1
            32   29  19 1

» Japanese version   » Back

KEGG   DRUG: Alfentanil hydrochlorideHelp
Entry
D00835                      Drug                                   

Name
Alfentanil hydrochloride (USP);
Alfenta (TN)
Product
  Generic
Formula
C21H32N6O3. HCl. H2O
Exact mass
470.2408
Mol weight
470.9934
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Remark
ATC code: N01AH02
Chemical structure group: DG00792
Product (DG00792): D00835<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
synthetic opioid
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH02 Alfentanil
      D00835  Alfentanil hydrochloride (USP) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00835  Alfentanil hydrochloride (USP) <US>
BRITE hierarchy
Other DBs
CAS: 69049-06-5
PubChem: 7847900
DrugBank: DB00802
LigandBox: D00835
NIKKAJI: J334.451G
LinkDB All DBs
KCF data Show

ATOM        32
            1   X   Cl   28.3560  -24.6925
            2   O0  O    31.3257  -24.6656
            3   C8x C    15.9600  -27.4400
            4   C8x C    15.9600  -28.8400
            5   C8x C    17.1500  -29.5400
            6   C8x C    18.4100  -28.8400
            7   C8y C    18.4100  -27.4400
            8   C8x C    17.1500  -26.7400
            9   N1c N    19.6000  -26.7400
            10  C1z C    20.8600  -27.4400
            11  C1x C    20.8600  -28.8400
            12  C1x C    22.0500  -29.5400
            13  N1y N    23.2400  -28.8400
            14  C1x C    23.2400  -27.4400
            15  C1x C    22.0500  -26.7400
            16  C1b C    24.5000  -29.5400
            17  C1b C    25.6900  -28.8400
            18  N4y N    26.8800  -29.5400
            19  N5x N    27.2300  -30.8700
            20  N5x N    28.6300  -30.8700
            21  N4y N    29.1200  -29.6100
            22  C8y C    28.0000  -28.7700
            23  C5a C    19.6000  -25.3400
            24  O5a O    18.4100  -24.6400
            25  C1b C    20.8600  -24.6400
            26  C1a C    22.0500  -25.3400
            27  C1b C    19.6000  -28.1400
            28  O2a O    19.6000  -29.5400
            29  C1a C    18.4100  -30.2400
            30  O5x O    28.0000  -27.3700
            31  C1b C    30.3100  -28.9100
            32  C1a C    31.5000  -29.6100
BOND        32
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     7   9 1
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   10  15 1
            15   13  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 2
            20   20  21 1
            21   21  22 1
            22   18  22 1
            23    9  23 1
            24   23  24 2
            25   23  25 1
            26   25  26 1
            27   10  27 1
            28   27  28 1
            29   28  29 1
            30   22  30 2
            31   31  32 1
            32   31  21 1

» Japanese version   » Back

KEGG   DRUG: SufentanilHelp
Entry
D05938                      Drug                                   

Name
Sufentanil (USAN/INN)
Formula
C22H30N2O2S
Exact mass
386.2028
Mol weight
386.5508
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Same as: C08022
ATC code: N01AH03
Chemical structure group: DG00793
Product (DG00793): D00845<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH03 Sufentanil
      D05938  Sufentanil (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D05938  Sufentanil (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05938
BRITE hierarchy
Other DBs
CAS: 56030-54-7
PubChem: 47207596
ChEBI: 9316
ChEMBL: CHEMBL658
DrugBank: DB00708
LigandBox: D05938
NIKKAJI: J11.105H
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8x C    17.1577  -27.3913
            2   C8x C    17.1577  -28.7920
            3   C8x C    18.3707  -29.4924
            4   C8x C    19.5838  -28.7920
            5   C8y C    19.5838  -27.3913
            6   C8x C    18.3707  -26.6909
            7   N1c N    20.8155  -26.6799
            8   C1z C    22.0213  -27.3760
            9   C1x C    22.0217  -28.7916
            10  C1x C    23.2350  -29.4916
            11  N1y N    24.4479  -28.7909
            12  C1x C    24.4474  -27.3752
            13  C1x C    23.2342  -26.6752
            14  C1b C    25.6567  -29.4883
            15  C1b C    26.8492  -28.7993
            16  C8y C    28.0393  -29.4859
            17  C8x C    28.4502  -30.8231
            18  C8x C    29.8542  -30.8454
            19  C8x C    30.3092  -29.5171
            20  S2x S    29.1866  -28.6738
            21  C5a C    20.8152  -25.2903
            22  O5a O    19.5903  -24.5833
            23  C1b C    22.0163  -24.5965
            24  C1a C    23.2069  -25.2837
            25  C1b C    20.7784  -28.0939
            26  O2a O    20.7784  -29.4947
            27  C1a C    19.5823  -30.1854
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   16  20 1
            23    7  21 1
            24   21  22 2
            25   21  23 1
            26   23  24 1
            27    8  25 1
            28   25  26 1
            29   26  27 1

» Japanese version   » Back

KEGG   DRUG: Sufentanil citrateHelp
Entry
D00845                      Drug                                   

Name
Sufentanil citrate (USP);
Dsuvia (TN);
Sufenta (TN)
Product
  Generic
Formula
C22H30N2O2S. C6H8O7
Exact mass
578.2298
Mol weight
578.6743
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
ATC code: N01AH03
Chemical structure group: DG00793
Product (DG00793): D00845<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH03 Sufentanil
      D00845  Sufentanil citrate (USP) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00845  Sufentanil citrate (USP) <US>
BRITE hierarchy
Other DBs
CAS: 60561-17-3
PubChem: 7847910
ChEBI: 9317
ChEMBL: CHEMBL1201163
DrugBank: DB00708
LigandBox: D00845
NIKKAJI: J269.155H
LinkDB All DBs
KCF data Show

ATOM        40
            1   C1d C    35.6633  -27.5656
            2   C1b C    34.4595  -28.2659
            3   C1b C    36.8796  -28.2598
            4   C6a C    36.3636  -26.3555
            5   O1a O    34.9630  -26.3495
            6   C6a C    33.2494  -27.5718
            7   C6a C    36.8796  -29.6540
            8   O6a O    35.6510  -25.1331
            9   O6a O    37.7581  -26.3555
            10  O6a O    32.0331  -28.2721
            11  O6a O    33.2432  -26.1713
            12  O6a O    38.0898  -30.3483
            13  O6a O    35.6573  -30.3483
            14  C8x C    17.1500  -27.4400
            15  C8x C    17.1500  -28.8400
            16  C8x C    18.3400  -29.5400
            17  C8x C    19.6000  -28.8400
            18  C8y C    19.6000  -27.4400
            19  C8x C    18.3400  -26.7400
            20  N1c N    20.7900  -26.7400
            21  C1z C    22.0500  -27.4400
            22  C1x C    22.0500  -28.8400
            23  C1x C    23.2400  -29.5400
            24  N1y N    24.4300  -28.8400
            25  C1x C    24.4300  -27.4400
            26  C1x C    23.2400  -26.7400
            27  C1b C    25.6900  -29.5400
            28  C1b C    26.8800  -28.8400
            29  C8y C    28.0700  -29.5400
            30  C8x C    28.4200  -30.8700
            31  C8x C    29.8200  -30.8700
            32  C8x C    30.3100  -29.6100
            33  S2x S    29.1900  -28.7700
            34  C5a C    20.7900  -25.3400
            35  O5a O    19.6000  -24.6400
            36  C1b C    22.0500  -24.6400
            37  C1a C    23.2400  -25.3400
            38  C1b C    20.7900  -28.1400
            39  O2a O    20.7900  -29.5400
            40  C1a C    19.6000  -30.2400
BOND        41
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   17  18 1
            17   18  19 2
            18   14  19 1
            19   18  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   25  26 1
            26   21  26 1
            27   24  27 1
            28   27  28 1
            29   28  29 1
            30   29  30 2
            31   30  31 1
            32   31  32 2
            33   32  33 1
            34   29  33 1
            35   20  34 1
            36   34  35 2
            37   34  36 1
            38   36  37 1
            39   21  38 1
            40   38  39 1
            41   39  40 1

» Japanese version   » Back

KEGG   DRUG: RemifentanilHelp
Entry
D08473                      Drug                                   

Name
Remifentanil (INN);
Ultiva (TN)
Formula
C20H28N2O5
Exact mass
376.1998
Mol weight
376.4467
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Remark
Same as: C08021
ATC code: N01AH06
Chemical structure group: DG00795
Product (DG00795): D01177<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH06 Remifentanil
      D08473  Remifentanil (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08473  Remifentanil (INN)
BRITE hierarchy
Other DBs
CAS: 132875-61-7
PubChem: 96025159
ChEBI: 8802
ChEMBL: CHEMBL1005
DrugBank: DB00899
LigandBox: D08473
NIKKAJI: J423.836B
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8x C    16.4500  -27.3700
            2   C8x C    16.4500  -28.7700
            3   C8x C    17.6400  -29.4700
            4   C8x C    18.9000  -28.7700
            5   C8y C    18.9000  -27.3700
            6   C8x C    17.6400  -26.6700
            7   N1c N    20.0900  -26.6700
            8   C1z C    21.3500  -27.3700
            9   C1x C    21.3500  -28.7700
            10  C1x C    22.5400  -29.4700
            11  N1y N    23.7300  -28.7700
            12  C1x C    23.7300  -27.3700
            13  C1x C    22.5400  -26.6700
            14  C1b C    24.9900  -29.4700
            15  C1b C    26.1800  -28.7700
            16  C7a C    27.3700  -29.4700
            17  C5a C    20.0900  -25.2700
            18  O5a O    18.9000  -24.5700
            19  C1b C    21.3500  -24.5700
            20  C1a C    22.5400  -25.2700
            21  C7a C    20.7200  -28.1400
            22  O7a O    28.5881  -28.7799
            23  C1a C    29.7695  -29.4750
            24  O6a O    27.3586  -30.8700
            25  O7a O    20.7200  -29.5400
            26  O6a O    19.5666  -27.8142
            27  C1a C    19.5076  -30.2400
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18    7  17 1
            19   17  18 2
            20   17  19 1
            21   19  20 1
            22    8  21 1
            23   16  22 1
            24   22  23 1
            25   16  24 2
            26   21  25 1
            27   21  26 2
            28   25  27 1

» Japanese version   » Back

KEGG   DRUG: Remifentanil hydrochlorideHelp
Entry
D01177                      Drug                                   

Name
Remifentanil hydrochloride (JAN/USAN);
Ultiva (TN)
Product
  Generic
Formula
C20H28N2O5. HCl
Exact mass
412.1765
Mol weight
412.9077
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Remark
Therapeutic category: 8219
ATC code: N01AH06
Chemical structure group: DG00795
Product (DG00795): D01177<JP/US>
Efficacy
Analgesic, Opioid receptor agonist
Comment
opioid
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH06 Remifentanil
      D01177  Remifentanil hydrochloride (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D01177  Remifentanil hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01177  Remifentanil hydrochloride (JAN/USAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01177
BRITE hierarchy
Other DBs
CAS: 132539-07-2
PubChem: 7848240
ChEBI: 32091
ChEMBL: CHEMBL1201120
DrugBank: DB00899
LigandBox: D01177
LinkDB All DBs
KCF data Show

ATOM        28
            1   X   Cl   29.6535  -25.6624
            2   C8x C    16.9400  -27.3700
            3   C8x C    16.9400  -28.8400
            4   C8x C    18.1300  -29.5400
            5   C8x C    19.3900  -28.8400
            6   C8y C    19.3900  -27.3700
            7   C8x C    18.1300  -26.6000
            8   N1c N    20.6500  -26.6000
            9   C1z C    21.9100  -27.3700
            10  C1x C    21.9100  -28.8400
            11  C1x C    23.1000  -29.5400
            12  N1y N    24.3600  -28.8400
            13  C1x C    24.3600  -27.3700
            14  C1x C    23.1000  -26.6000
            15  C1b C    25.6200  -29.5400
            16  C1b C    26.8100  -28.8400
            17  C7a C    28.0700  -29.5400
            18  C5a C    20.6500  -25.2000
            19  O5a O    19.3900  -24.5000
            20  C1b C    21.9100  -24.5000
            21  C1a C    23.1000  -25.2000
            22  C7a C    21.1400  -28.5600
            23  O7a O    29.3300  -28.8400
            24  C1a C    30.5200  -29.5400
            25  O6a O    28.0000  -30.9400
            26  O7a O    21.1400  -29.9600
            27  C1a C    19.9276  -30.6600
            28  O6a O    19.9373  -28.1635
BOND        28
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18    8  18 1
            19   18  19 2
            20   18  20 1
            21   20  21 1
            22    9  22 1
            23   17  23 1
            24   23  24 1
            25   17  25 2
            26   22  26 1
            27   26  27 1
            28   22  28 2

» Japanese version   » Back

KEGG   DRUG: Brifentanil hydrochlorideHelp
Entry
D03156                      Drug                                   

Name
Brifentanil hydrochloride (USAN)
Formula
C20H29FN6O3. HCl
Exact mass
456.2052
Mol weight
456.942
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D03156  Brifentanil hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 117268-95-8
PubChem: 17397310
LigandBox: D03156
LinkDB All DBs
KCF data Show

ATOM        31
            1   X   Cl   31.9900  -25.9000
            2   C8x C    15.9600  -27.4400
            3   C8x C    15.9600  -28.8400
            4   C8x C    17.1500  -29.5400
            5   C8x C    18.4100  -28.8400
            6   C8y C    18.4100  -27.4400
            7   C8y C    17.1500  -26.7400
            8   N1c N    19.6000  -26.7400
            9   C1y C    20.8600  -27.4400
            10  C1y C    20.8600  -28.8400
            11  C1x C    22.0500  -29.5400
            12  N1y N    23.2400  -28.8400
            13  C1x C    23.2400  -27.4400
            14  C1x C    22.0500  -26.7400
            15  C1b C    24.5000  -29.5400
            16  C1b C    25.6900  -28.8400
            17  N4y N    26.8800  -29.5400
            18  N5x N    27.2300  -30.8700
            19  N5x N    28.6300  -30.8700
            20  N4y N    29.1200  -29.6100
            21  C8y C    28.0000  -28.7700
            22  C5a C    19.6000  -25.3400
            23  O5a O    18.4100  -24.6400
            24  C1b C    20.8600  -24.6400
            25  O2a O    22.0500  -25.3400
            26  O5x O    28.0000  -27.3700
            27  C1b C    30.3100  -28.9100
            28  C1a C    31.5000  -29.6100
            29  C1a C    19.6447  -29.5351
            30  C1a C    23.2681  -24.6499
            31  X   F    17.1328  -25.3401
BOND        32
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     9   8 1 #Down
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 1
            22   17  21 1
            23    8  22 1
            24   22  23 2
            25   22  24 1
            26   24  25 1
            27   21  26 2
            28   27  28 1
            29   27  20 1
            30   10  29 1 #Down
            31   25  30 1
            32    7  31 1

» Japanese version   » Back

KEGG   DRUG: CarfentanilHelp
Entry
D07620                      Drug                                   

Name
Carfentanil (INN)
Formula
C24H30N2O3
Exact mass
394.2256
Mol weight
394.5066
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Chemical structure group: DG01339
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07620  Carfentanil (INN)
BRITE hierarchy
Other DBs
CAS: 59708-52-0
PubChem: 96024451
ChEBI: 61084
ChEMBL: CHEMBL290429
DrugBank: DB01535
LigandBox: D07620
NIKKAJI: J18.086F
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8x C    17.0100  -27.4400
            2   C8x C    17.0100  -28.8400
            3   C8x C    18.2000  -29.5400
            4   C8x C    19.4600  -28.8400
            5   C8y C    19.4600  -27.4400
            6   C8x C    18.2000  -26.6700
            7   N1c N    20.7200  -26.6700
            8   C1z C    21.9800  -27.4400
            9   C1x C    21.9800  -28.8400
            10  C1x C    23.1700  -29.5400
            11  N1y N    24.4300  -28.8400
            12  C1x C    24.4300  -27.4400
            13  C1x C    23.1700  -26.6700
            14  C1b C    25.6900  -29.5400
            15  C1b C    26.8800  -28.8400
            16  C8y C    28.1400  -29.5400
            17  C5a C    20.7200  -25.2700
            18  O5a O    19.4600  -24.5700
            19  C1b C    21.9800  -24.5700
            20  C1a C    23.1700  -25.2700
            21  C7a C    21.3500  -28.5600
            22  O7a O    21.3500  -29.9600
            23  C1a C    20.1376  -30.6600
            24  O6a O    19.9957  -28.2052
            25  C8x C    28.1631  -30.9398
            26  C8x C    29.3869  -31.6197
            27  C8x C    30.5876  -30.8998
            28  C8x C    30.5645  -29.5000
            29  C8x C    29.3407  -28.8201
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18    7  17 1
            19   17  18 2
            20   17  19 1
            21   19  20 1
            22    8  21 1
            23   21  22 1
            24   22  23 1
            25   21  24 2
            26   16  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   16  29 1

» Japanese version   » Back

KEGG   DRUG: Carfentanil citrateHelp
Entry
D03405                      Drug                                   

Name
Carfentanil citrate (USAN)
Formula
C24H30N2O3. C6H8O7
Exact mass
586.2526
Mol weight
586.6301
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Chemical structure group: DG01339
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D03405  Carfentanil citrate (USAN)
BRITE hierarchy
Other DBs
CAS: 61380-27-6
PubChem: 17397545
ChEMBL: CHEMBL2106383
LigandBox: D03405
NIKKAJI: J244.996J
LinkDB All DBs
KCF data Show

ATOM        42
            1   C1d C    35.6695  -27.0822
            2   C1b C    34.4671  -27.7734
            3   C1b C    36.8720  -27.7674
            4   C6a C    36.3548  -25.8737
            5   O1a O    34.9665  -25.8737
            6   C6a C    33.2703  -27.0879
            7   C6a C    36.8607  -29.1561
            8   O6a O    35.6521  -24.6657
            9   O6a O    37.7491  -25.8737
            10  O6a O    32.0679  -27.7851
            11  O6a O    33.2574  -25.6995
            12  O6a O    38.0630  -29.8530
            13  O6a O    35.6521  -29.8471
            14  C8x C    17.0100  -27.0200
            15  C8x C    17.0100  -28.4200
            16  C8x C    18.2000  -29.1200
            17  C8x C    19.3900  -28.4200
            18  C8y C    19.3900  -27.0200
            19  C8x C    18.2000  -26.3200
            20  N1c N    20.6500  -26.3200
            21  C1z C    21.9100  -27.0200
            22  C1x C    21.9100  -28.4200
            23  C1x C    23.1000  -29.1200
            24  N1y N    24.3600  -28.4200
            25  C1x C    24.3600  -27.0200
            26  C1x C    23.1000  -26.3200
            27  C1b C    25.6200  -29.1200
            28  C1b C    26.8100  -28.4200
            29  C8y C    28.0000  -29.1200
            30  C5a C    20.6500  -24.9200
            31  O5a O    19.3900  -24.2200
            32  C1b C    21.9100  -24.2200
            33  C1a C    23.1000  -24.9200
            34  C7a C    21.2800  -28.1400
            35  O7a O    21.2800  -29.5400
            36  C1a C    20.0900  -30.2400
            37  O6a O    19.9500  -27.7900
            38  C8x C    28.0000  -30.5200
            39  C8x C    29.2600  -31.2200
            40  C8x C    30.4500  -30.4500
            41  C8x C    30.4500  -29.1200
            42  C8x C    29.1900  -28.4200
BOND        43
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   17  18 1
            17   18  19 2
            18   14  19 1
            19   18  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   25  26 1
            26   21  26 1
            27   24  27 1
            28   27  28 1
            29   28  29 1
            30   20  30 1
            31   30  31 2
            32   30  32 1
            33   32  33 1
            34   21  34 1
            35   34  35 1
            36   35  36 1
            37   34  37 2
            38   29  38 2
            39   38  39 1
            40   39  40 2
            41   40  41 1
            42   41  42 2
            43   29  42 1

» Japanese version   » Back

KEGG   DRUG: Lofentanil oxalateHelp
Entry
D04764                      Drug                                   

Name
Lofentanil oxalate (USAN)
Formula
C25H32N2O3. C2H2O4
Exact mass
498.2366
Mol weight
498.5681
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D04764  Lofentanil oxalate (USAN)
BRITE hierarchy
Other DBs
CAS: 61380-41-4
PubChem: 47206579
LigandBox: D04764
NIKKAJI: J365.046D
LinkDB All DBs
KCF data Show

ATOM        36
            1   C6a C    30.5325  -27.0660
            2   C6a C    31.6601  -26.3612
            3   O6a O    29.3344  -26.3612
            4   O6a O    30.5325  -28.4754
            5   O6a O    32.8581  -27.0660
            6   O6a O    31.6601  -25.1631
            7   C8x C    14.6053  -27.0660
            8   C8x C    14.6053  -28.4754
            9   C8x C    15.8033  -29.1802
            10  C8x C    17.0719  -28.4754
            11  C8y C    17.0719  -27.0660
            12  C8x C    15.8033  -26.2907
            13  N1c N    18.3404  -26.2907
            14  C1z C    19.6090  -27.0660
            15  C1y C    19.6090  -28.4754
            16  C1x C    20.8070  -29.1802
            17  N1y N    22.0756  -28.4754
            18  C1x C    22.0756  -27.0660
            19  C1x C    20.8070  -26.2907
            20  C1b C    23.3441  -29.1802
            21  C1b C    24.5422  -28.4754
            22  C8y C    25.8107  -29.1802
            23  C5a C    18.3404  -24.8812
            24  O5a O    17.0719  -24.1765
            25  C1b C    19.6090  -24.1765
            26  C1a C    20.8070  -24.8812
            27  C7a C    18.7647  -27.8412
            28  O7a O    18.7647  -29.2507
            29  O6a O    17.7066  -27.5588
            30  C1a C    17.7061  -29.9554
            31  C8x C    25.8340  -30.5895
            32  C8x C    27.0660  -31.2740
            33  C8x C    28.2749  -30.5492
            34  C8x C    28.2516  -29.1399
            35  C8x C    27.0195  -28.4554
            36  C1a C    19.6090  -30.1554
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     7   8 2
            7     8   9 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11    7  12 1
            12   11  13 1
            13   14  13 1 #Down
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   14  19 1
            20   17  20 1
            21   20  21 1
            22   21  22 1
            23   13  23 1
            24   23  24 2
            25   23  25 1
            26   25  26 1
            27   14  27 1 #Up
            28   27  28 1
            29   27  29 2
            30   28  30 1
            31   22  31 2
            32   31  32 1
            33   32  33 2
            34   33  34 1
            35   34  35 2
            36   22  35 1
            37   15  36 1 #Down

» Japanese version   » Back

KEGG   DRUG: Mirfentanil hydrochlorideHelp
Entry
D05048                      Drug                                   

Name
Mirfentanil hydrochloride (USAN)
Formula
C22H24N4O2. HCl
Exact mass
412.1666
Mol weight
412.9125
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D05048  Mirfentanil hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 119413-53-5
PubChem: 47206775
ChEMBL: CHEMBL2448139
LigandBox: D05048
LinkDB All DBs
KCF data Show

ATOM        29
            1   X   Cl   28.9801  -26.0360
            2   N5x N    17.1095  -27.7218
            3   C8x C    17.1095  -29.1266
            4   C8x C    18.3261  -29.8290
            5   N5x N    19.5427  -29.1266
            6   C8y C    19.5427  -27.7218
            7   C8x C    18.3261  -27.0194
            8   N1c N    20.7781  -27.0083
            9   C1y C    21.9874  -27.7064
            10  C1x C    21.9878  -29.1262
            11  C1x C    23.2046  -29.8283
            12  N1y N    24.4210  -29.1255
            13  C1x C    24.4205  -27.7056
            14  C1x C    23.2038  -27.0036
            15  C1b C    25.6334  -29.8250
            16  C1b C    26.8293  -29.1339
            17  C8y C    28.0229  -29.8225
            18  C8x C    28.0235  -31.2335
            19  C8x C    29.2404  -31.9355
            20  C8x C    30.4566  -31.2326
            21  C8x C    30.4561  -29.8215
            22  C8x C    29.2393  -29.1196
            23  C5a C    20.7778  -25.6147
            24  O5a O    19.5493  -24.9055
            25  C8y C    21.9824  -24.9188
            26  O2x O    23.0828  -25.7511
            27  C8x C    24.2098  -24.9579
            28  C8x C    23.8036  -23.6410
            29  C8x C    22.4257  -23.6205
BOND        31
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24    8  23 1
            25   23  24 2
            26   23  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   25  29 2

» Japanese version   » Back

KEGG   DRUG: Ocfentanil hydrochlorideHelp
Entry
D05217                      Drug                                   

Name
Ocfentanil hydrochloride (USAN)
Formula
C22H27FN2O2. HCl
Exact mass
406.1823
Mol weight
406.9213
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D05217  Ocfentanil hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 112964-97-3
PubChem: 47206936
ChEMBL: CHEMBL2106652
LigandBox: D05217
LinkDB All DBs
KCF data Show

ATOM        28
            1   X   Cl   29.6489  -25.7248
            2   C8x C    17.0995  -27.0568
            3   C8x C    17.0995  -28.4590
            4   C8x C    18.3137  -29.1601
            5   C8x C    19.5281  -28.4590
            6   C8y C    19.5281  -27.0568
            7   C8y C    18.3137  -26.3558
            8   N1c N    20.7611  -26.3447
            9   C1y C    21.9682  -27.0415
            10  C1x C    21.9686  -28.4586
            11  C1x C    23.1831  -29.1594
            12  N1y N    24.3973  -28.4579
            13  C1x C    24.3968  -27.0407
            14  C1x C    23.1823  -26.3400
            15  C5a C    20.7608  -24.9537
            16  O5a O    19.5346  -24.2459
            17  C1b C    21.9632  -24.2591
            18  O2a O    23.1550  -24.9471
            19  C1a C    24.3467  -24.2587
            20  X   F    18.3137  -24.9538
            21  C1b C    25.6073  -29.1561
            22  C1b C    26.8011  -28.4663
            23  C8y C    27.9924  -29.1537
            24  C8x C    27.9930  -30.5620
            25  C8x C    29.2076  -31.2627
            26  C8x C    30.4216  -30.5611
            27  C8x C    30.4211  -29.1527
            28  C8x C    29.2065  -28.4521
BOND        29
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15    8  15 1
            16   15  16 2
            17   15  17 1
            18   17  18 1
            19   18  19 1
            20    7  20 1
            21   12  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1

» Japanese version   » Back

KEGG   DRUG: Trefentanil hydrochlorideHelp
Entry
D06208                      Drug                                   

Name
Trefentanil hydrochloride (USAN)
Formula
C25H31FN6O2. HCl
Exact mass
502.2259
Mol weight
503.012
Structure
Mol fileKCF fileDB search
Class
Analgesic
 DG01984  Opioid analgesics
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D06208  Trefentanil hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 120656-93-1
PubChem: 47207866
ChEMBL: CHEMBL2107275
LigandBox: D06208
LinkDB All DBs
KCF data Show

ATOM        35
            1   X   Cl   30.5200  -25.3400
            2   C8x C    15.9600  -27.4400
            3   C8x C    15.9600  -28.8400
            4   C8x C    17.1500  -29.5400
            5   C8x C    18.4100  -28.8400
            6   C8y C    18.4100  -27.4400
            7   C8y C    17.1500  -26.7400
            8   N1c N    19.6000  -26.7400
            9   C1z C    20.8600  -27.4400
            10  C1x C    20.8600  -28.8400
            11  C1x C    22.0500  -29.5400
            12  N1y N    23.2400  -28.8400
            13  C1x C    23.2400  -27.4400
            14  C1x C    22.0500  -26.7400
            15  C1b C    24.5000  -29.5400
            16  C1b C    25.6900  -28.8400
            17  N4y N    26.8800  -29.5400
            18  N5x N    27.2300  -30.8700
            19  N5x N    28.6300  -30.8700
            20  N4y N    29.1200  -29.6100
            21  C8y C    28.0000  -28.7700
            22  C5a C    19.6000  -25.3400
            23  O5a O    18.4100  -24.6400
            24  C1b C    20.8600  -24.6400
            25  C1a C    22.0500  -25.3400
            26  O5x O    28.0000  -27.3700
            27  C1b C    30.3100  -28.9100
            28  C1a C    31.5000  -29.6100
            29  X   F    17.1328  -25.3401
            30  C8x C    18.3400  -29.7500
            31  C8x C    18.3400  -31.1500
            32  C8x C    19.5524  -31.8500
            33  C8x C    20.7649  -31.1500
            34  C8x C    20.7649  -29.7500
            35  C8y C    19.5524  -29.0500
BOND        37
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 1
            22   17  21 1
            23    8  22 1
            24   22  23 2
            25   22  24 1
            26   24  25 1
            27   21  26 2
            28   27  28 1
            29   27  20 1
            30    7  29 1
            31   30  31 2
            32   31  32 1
            33   32  33 2
            34   33  34 1
            35   34  35 2
            36   30  35 1
            37    9  35 1

» Japanese version   » Back

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