KEGG   DRUG: BeclometasoneHelp
Entry
D07495                      Drug                                   

Name
Beclometasone (INN);
Beclometason (TN)
Formula
C22H29ClO5
Exact mass
408.1704
Mol weight
408.9157
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C06842
ATC code: A07EA07 D07AC15 R01AD01 R03BA01
Chemical structure group: DG00097
Product (DG00097): D00689<JP/US> D11572<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA07 Beclometasone
      D07495  Beclometasone (INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC15 Beclometasone
      D07495  Beclometasone (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD01 Beclometasone
      D07495  Beclometasone (INN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA01 Beclometasone
      D07495  Beclometasone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07495  Beclometasone (INN)
BRITE hierarchy
Other DBs
CAS: 4419-39-0
PubChem: 51091820
ChEBI: 3001
ChEMBL: CHEMBL1435313 CHEMBL1489447 CHEMBL1586 CHEMBL1881863 CHEMBL67130
DrugBank: DB00394
LigandBox: D07495
NIKKAJI: J8.720C
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1z C    25.9700  -17.5700
            2   C1z C    24.7800  -18.2000
            3   C1y C    27.1600  -18.2700
            4   C1y C    24.7800  -19.6000
            5   C1x C    23.5900  -17.5000
            6   C1a C    24.7800  -16.8000
            7   C1x C    27.1600  -19.6000
            8   C1a C    28.3500  -18.9000
            9   C1y C    23.5900  -20.2300
            10  C1y C    22.4000  -18.2000
            11  C1z C    22.4000  -19.5300
            12  C1x C    23.5900  -21.5600
            13  O1a O    21.2800  -17.5000
            14  C1z C    21.2100  -20.2300
            15  X   Cl   22.4000  -20.9300
            16  C1x C    22.4000  -22.2600
            17  C2y C    21.2100  -21.5600
            18  C2x C    20.0900  -19.5300
            19  C1a C    21.2100  -18.8300
            20  C2x C    20.0900  -22.2600
            21  C2x C    18.9000  -20.2300
            22  C5x C    18.9000  -21.5600
            23  O5x O    17.7100  -22.2600
            24  O1a O    27.3223  -17.2077
            25  C5a C    25.9700  -16.1700
            26  C1b C    27.1824  -15.4700
            27  O5a O    24.7576  -15.4700
            28  O1a O    28.3779  -16.1604
BOND        31
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1 #Up
            8     4   9 1
            9     5  10 1
            10    9  11 1
            11    9  12 1
            12   10  13 1 #Up
            13   11  14 1
            14   11  15 1 #Down
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   14  19 1 #Up
            19   17  20 2
            20   18  21 2
            21   20  22 1
            22   22  23 2
            23    4   7 1
            24   10  11 1
            25   16  17 1
            26   21  22 1
            27    1  24 1 #Down
            28    1  25 1 #Up
            29   25  26 1
            30   25  27 2
            31   26  28 1

» Japanese version   » Back

KEGG   DRUG: Beclomethasone dipropionateHelp
Entry
D00689                      Drug                                   

Name
Beclomethasone dipropionate (USP);
Beclometasone dipropionate (JP17);
Beclovent (TN);
Qnasl (TN);
Vanceril (TN)
Product
Formula
C28H37ClO7
Exact mass
520.2228
Mol weight
521.0422
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C07813
Therapeutic category: 1329 2290 2459 2646
ATC code: A07EA07 D07AC15 R01AD01 R03BA01
Chemical structure group: DG00097
Product (DG00097): D00689<JP/US> D11572<US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Allergic rhinitis [DS:H01360]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA07 Beclometasone
      D00689  Beclomethasone dipropionate (USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC15 Beclometasone
      D00689  Beclomethasone dipropionate (USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD01 Beclometasone
      D00689  Beclomethasone dipropionate (USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA01 Beclometasone
      D00689  Beclomethasone dipropionate (USP) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Beclomethasone
    D00689  Beclomethasone dipropionate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D00689  Beclomethasone dipropionate (USP); Beclometasone dipropionate (JP17)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D00689  Beclomethasone dipropionate (USP); Beclometasone dipropionate (JP17)
  24  Hormones
   245  Adrenal hormone preparations
    2459  Others
     D00689  Beclomethasone dipropionate (USP); Beclometasone dipropionate (JP17)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00689  Beclomethasone dipropionate (USP); Beclometasone dipropionate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  70 Nasal sprays for inflammation
   D00689  Beclomethasone dipropionate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Beclometasone dipropionate
    D00689  Beclomethasone dipropionate (USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Beclometasone dipropionate
    D00689  Beclomethasone dipropionate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00689  Beclomethasone dipropionate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00689  Beclometasone dipropionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00689
Topical steroids potency [br08317.html]
 Classification in Japan
  D00689
Rx-to-OTC switch list in Japan [br08314.html]
 D00689
BRITE hierarchy
Other DBs
CAS: 5534-09-8
PubChem: 7847755
ChEBI: 3002
ChEMBL: CHEMBL1200500
DrugBank: DB00394
LigandBox: D00689
NIKKAJI: J7.992H
LinkDB All DBs
KCF data Show

ATOM        36
            1   C1z C    23.0609  -16.7586
            2   C1z C    21.8700  -17.4241
            3   C1y C    24.2402  -17.4591
            4   C5a C    23.0842  -14.9491
            5   O7a O    24.2576  -16.0521
            6   C1y C    21.8467  -18.7959
            7   C1x C    20.6790  -16.7352
            8   C1a C    21.8583  -16.0289
            9   C1x C    24.2226  -18.8309
            10  C1a C    25.4368  -18.1537
            11  C1b C    21.8932  -14.2369
            12  O5a O    24.2984  -14.2719
            13  C7a C    25.6411  -16.0521
            14  C1y C    20.6557  -19.4673
            15  C1y C    19.4939  -17.4007
            16  O7a O    20.6849  -14.9258
            17  C1b C    26.3242  -14.8553
            18  O6a O    26.3359  -17.2548
            19  C1z C    19.4823  -18.7784
            20  C1x C    20.6557  -20.8334
            21  O1a O    18.3031  -16.7235
            22  C7a C    19.4823  -14.2311
            23  C1a C    27.7077  -14.8553
            24  C1z C    18.2914  -19.4556
            25  X   Cl   19.4706  -20.1386
            26  C1x C    19.4706  -21.5163
            27  C1b C    18.2855  -14.9258
            28  O6a O    19.4765  -12.8417
            29  C2y C    18.2855  -20.8275
            30  C2x C    17.1063  -18.7725
            31  C1a C    18.2797  -18.0836
            32  C1a C    17.0887  -14.2311
            33  C2x C    17.1063  -21.5106
            34  C2x C    15.9270  -19.4556
            35  C5x C    15.9270  -20.8275
            36  O5x O    14.7362  -21.5046
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     3  10 1 #Up
            10    4  11 1
            11    4  12 2
            12    5  13 1
            13    6  14 1
            14    7  15 1
            15   11  16 1
            16   13  17 1
            17   13  18 2
            18   14  19 1
            19   14  20 1
            20   15  21 1 #Up
            21   16  22 1
            22   17  23 1
            23   19  24 1
            24   19  25 1 #Down
            25   20  26 1
            26   22  27 1
            27   22  28 2
            28   24  29 1
            29   24  30 1
            30   24  31 1 #Up
            31   27  32 1
            32   29  33 2
            33   30  34 2
            34   33  35 1
            35   35  36 2
            36    6   9 1
            37   15  19 1
            38   26  29 1
            39   34  35 1

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