KEGG   DRUG: ChlormadinoneHelp
Entry
D07670                      Drug                                   

Name
Chlormadinone (INN)
Formula
C21H27ClO3
Exact mass
362.1649
Mol weight
362.8903
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
ATC code: G03DB06
Chemical structure group: DG00469
Product (DG00469): D01299<JP>
Efficacy
Menstruation disorder agent, Prostatic hyperplasia treatment, Progesterone receptor agonist, Androgen receptor antagonist
Comment
Progestin, Pregnadien derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
NR3C4 (AR) [HSA:367] [KO:K08557]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB06 Chlormadinone
      D07670  Chlormadinone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D07670  Chlormadinone (INN)
    NR3C4 (AR)
     D07670  Chlormadinone (INN)
BRITE hierarchy
Other DBs
CAS: 1961-77-9
PubChem: 51091972
ChEMBL: CHEMBL1697830
LigandBox: D07670
NIKKAJI: J13.853C
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1z C    22.2255  -14.2313
            2   C1z C    21.0340  -14.8622
            3   C1x C    23.3470  -14.8622
            4   O1a O    23.3470  -13.5304
            5   C5a C    22.2255  -12.8295
            6   C1y C    21.0340  -16.2640
            7   C1x C    19.8424  -14.1612
            8   C1a C    21.0340  -13.5304
            9   C1x C    23.3470  -16.2640
            10  C1a C    21.0339  -12.1285
            11  O5a O    23.4170  -12.1285
            12  C1y C    19.8424  -16.9650
            13  C1x C    18.6508  -14.8622
            14  C1y C    18.6508  -16.2640
            15  C2x C    19.8424  -18.2968
            16  C1z C    17.4592  -16.8949
            17  C2y C    18.6508  -18.9977
            18  C2y C    17.4592  -18.2968
            19  C1x C    16.2676  -16.1939
            20  C1a C    17.4592  -15.5631
            21  X   Cl   18.6507  -20.3295
            22  C2x C    16.2676  -18.9977
            23  C1x C    15.0760  -16.8949
            24  C5x C    15.0760  -18.2968
            25  O5x O    13.8844  -18.9977
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13   12  14 1
            14   12  15 1
            15   14  16 1
            16   15  17 2
            17   16  18 1
            18   16  19 1
            19   16  20 1 #Up
            20   17  21 1
            21   18  22 2
            22   19  23 1
            23   22  24 1
            24   24  25 2
            25    6   9 1
            26   13  14 1
            27   17  18 1
            28   23  24 1

» Japanese version   » Back

KEGG   DRUG: Chlormadinone acetateHelp
Entry
D01299                      Drug                                   

Name
Chlormadinone acetate (JP17/USAN);
Lutoral (TN)
Formula
C23H29ClO4
Exact mass
404.1754
Mol weight
404.927
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
Same as: C12729
Therapeutic category: 2478
ATC code: G03DB06
Chemical structure group: DG00469
Product (DG00469): D01299<JP>
Efficacy
Menstruation disorder agent, Prostatic hyperplasia treatment, Progesterone receptor agonist, Androgen receptor antagonist
Comment
Progestin, Pregnadien derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
NR3C4 (AR) [HSA:367] [KO:K08557]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa05215  Prostate cancer
Interaction
Drug interaction
Structure map
map07043  Antineoplastics - hormones
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB06 Chlormadinone
      D01299  Chlormadinone acetate (JP17/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2478  Synthetic progestins
     D01299  Chlormadinone acetate (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D01299  Chlormadinone acetate (JP17/USAN) <JP>
    NR3C4 (AR)
     D01299  Chlormadinone acetate (JP17/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01299  Chlormadinone acetate
BRITE hierarchy
Other DBs
CAS: 302-22-7
PubChem: 7848362
ChEBI: 31394
ChEMBL: CHEMBL110691
LigandBox: D01299
NIKKAJI: J5.478J
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1z C    34.0635  -15.4455
            2   C1z C    32.8751  -16.1154
            3   C1x C    35.2406  -16.1271
            4   O7a O    35.2406  -14.7520
            5   C5a C    34.1921  -14.0704
            6   C1y C    32.9334  -17.4848
            7   C1x C    31.7039  -15.4279
            8   C1x C    35.2290  -17.4964
            9   C7a C    36.4293  -15.4338
            10  C1a C    32.9918  -13.3769
            11  O5a O    35.3749  -13.3712
            12  C1y C    31.6806  -18.1664
            13  C1x C    30.5094  -16.0980
            14  C1a C    37.6120  -14.7463
            15  O6a O    36.4235  -16.8089
            16  C1y C    30.4978  -17.4672
            17  C2x C    31.6806  -19.5357
            18  C1z C    29.3091  -18.1490
            19  C2y C    30.4861  -20.2174
            20  C2y C    29.3034  -19.5241
            21  C1x C    28.1265  -17.4615
            22  C1a C    29.2977  -16.7797
            23  X   Cl   30.5445  -21.5867
            24  C2x C    28.1265  -20.2174
            25  C1x C    26.9320  -18.1490
            26  C5x C    26.9320  -19.5241
            27  O5x O    25.7433  -20.2057
            28  C1a C    32.8751  -14.7154
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    9  14 1
            14    9  15 2
            15   12  16 1
            16   12  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 1
            20   18  21 1
            21   18  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   24  26 1
            26   26  27 2
            27    6   8 1
            28   13  16 1
            29   19  20 1
            30   25  26 1
            31    2  28 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system