KEGG   DRUG: Colistin
Entry
D07746                      Drug                                   

Name
Colistin (INN);
Sogecoli (TN)
Formula
C52H97N16O13R
Structure
Source
Bacillus polymyxa var. colistinus
Class
Antibacterial
 DG01579  Polypeptide antibiotic
Remark
ATC code: A07AA10 J01XB01
Chemical structure group: DG00087
Product (DG00087): D02049<JP/US>
Efficacy
Antibacterial, Cell membrane function inhibitor
Comment
Natural product
Polypeptide
Target
Lipopolysaccharide
Interaction
Other map
map01501  beta-Lactam resistance
map01503  Cationic antimicrobial peptide (CAMP) resistance
map02020  Two-component system
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA10 Colistin
      D07746  Colistin (INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XB Polymyxins
     J01XB01 Colistin
      D07746  Colistin (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Colistin
    D07746  Colistin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell membrane function inhibitor
   Polypeptide
    D07746  Colistin (INN)
Other DBs
CAS: 1066-17-7
PubChem: 51092040
DrugBank: DB00803
NIKKAJI: J861C
LinkDB
KCF data

ATOM        82
            1   C1c C    34.4400  -24.2900
            2   C1a C    35.6300  -24.9900
            3   O1a O    33.1800  -24.9900
            4   C1c C    30.8000  -16.3800
            5   N1b N    30.8000  -17.7800
            6   N1b N    33.1800  -16.3800
            7   C5a C    31.9900  -15.6800
            8   C5a C    35.6300  -16.3800
            9   C1c C    34.4400  -15.6800
            10  C1c C    38.0800  -16.3800
            11  N1b N    36.8200  -15.6800
            12  C5a C    29.5400  -18.4100
            13  C1c C    29.5400  -19.8100
            14  C1b C    30.8000  -20.5800
            15  C1b C    30.8000  -21.9800
            16  N1b N    31.9900  -22.6100
            17  C5a C    33.1800  -21.9800
            18  C1c C    34.4400  -22.6100
            19  N1b N    35.6300  -21.9800
            20  C5a C    36.8200  -22.6100
            21  C1c C    38.0800  -21.9800
            22  O5a O    31.9900  -14.2800
            23  C1c C    40.4600  -16.3800
            24  C1b C    39.2700  -15.6800
            25  C1b C    34.4400  -14.0000
            26  C5a C    38.0800  -17.7800
            27  C1a C    41.7200  -15.6800
            28  C1a C    40.4600  -17.7800
            29  O5a O    36.8200  -18.4100
            30  C1c C    35.6300  -13.3000
            31  C1a C    36.8900  -14.0000
            32  C1a C    35.6300  -11.8300
            33  O5a O    35.6300  -17.7800
            34  C1b C    29.5400  -15.6800
            35  O5a O    28.3500  -17.7800
            36  N1b N    28.3500  -20.5800
            37  O5a O    33.1800  -20.5800
            38  O5a O    36.8200  -24.0100
            39  N1b N    38.0800  -20.5800
            40  C5a C    39.4800  -20.5800
            41  N1b N    39.2700  -18.4100
            42  C1c C    40.1800  -19.3900
            43  C1b C    41.5800  -19.3900
            44  C1b C    39.2700  -22.6100
            45  C1b C    39.2700  -24.0100
            46  N1a N    40.4600  -24.7100
            47  C1b C    29.5400  -14.2800
            48  N1a N    28.3500  -13.5800
            49  C5a C    27.1600  -19.8100
            50  C1c C    25.9000  -20.5800
            51  N1b N    24.7100  -19.8100
            52  C5a C    23.5200  -20.5800
            53  C1c C    22.2600  -19.8100
            54  N1b N    21.0700  -20.5800
            55  C5a C    19.8800  -19.8100
            56  C1c C    18.6200  -20.5800
            57  N1b N    17.4300  -19.8100
            58  C5a C    16.2400  -20.5800
            59  C1b C    15.0500  -19.8100
            60  C1b C    13.7900  -20.5800
            61  C1b C    12.6000  -19.8100
            62  C1b C    11.3400  -20.5800
            63  C1c C    10.1500  -19.8100
            64  C1b C     8.9600  -20.5800
            65  R   R     7.7700  -19.8100
            66  O5a O    27.1600  -18.4100
            67  C1b C    25.9000  -21.9800
            68  O5a O    23.5200  -21.9800
            69  C1c C    22.2600  -18.0600
            70  C1a C    21.0700  -17.4300
            71  O1a O    23.5200  -17.4300
            72  O5a O    19.8800  -18.4100
            73  C1b C    18.6200  -21.9800
            74  O5a O    16.2400  -21.9800
            75  C1a C    10.1500  -18.4100
            76  C1b C    24.7100  -22.6100
            77  N1a N    24.7100  -24.0100
            78  C1b C    17.4300  -22.6100
            79  N1a N    17.4300  -24.0100
            80  O5a O    40.1800  -21.7700
            81  C1b C    42.2800  -20.5800
            82  N1a N    43.6800  -20.5800
BOND        82
            1     1   2 1
            2     1   3 1
            3    17  18 1
            4    18  19 1
            5    19  20 1
            6    20  21 1
            7     7  22 2
            8    23  24 1
            9    10  24 1
            10    9  25 1
            11   10  26 1
            12   23  27 1
            13   23  28 1
            14   26  29 2
            15   25  30 1
            16   30  31 1
            17   30  32 1
            18    8  33 2
            19    4  34 1
            20   12  35 2
            21   13  36 1
            22   17  37 2
            23   20  38 2
            24   21  39 1
            25   39  40 1
            26   26  41 1
            27   40  42 1
            28   41  42 1
            29   42  43 1
            30   21  44 1
            31   44  45 1
            32   45  46 1
            33   34  47 1
            34   47  48 1
            35   36  49 1
            36   49  50 1
            37   50  51 1
            38   51  52 1
            39   52  53 1
            40   53  54 1
            41   54  55 1
            42   55  56 1
            43   56  57 1
            44   57  58 1
            45   58  59 1
            46   59  60 1
            47   60  61 1
            48   61  62 1
            49   62  63 1
            50   63  64 1
            51   64  65 1
            52   49  66 2
            53   50  67 1
            54   52  68 2
            55   53  69 1
            56   69  70 1
            57   69  71 1
            58   55  72 2
            59   56  73 1
            60   58  74 2
            61   63  75 1
            62   67  76 1
            63   76  77 1
            64   73  78 1
            65   78  79 1
            66   40  80 2
            67    4   5 1
            68    6   7 1
            69    4   7 1
            70    8   9 1
            71    6   9 1
            72   10  11 1
            73    8  11 1
            74    5  12 1
            75   12  13 1
            76   13  14 1
            77   14  15 1
            78   15  16 1
            79   16  17 1
            80    1  18 1
            81   43  81 1
            82   81  82 1

» Japanese version   » Back

KEGG   DRUG: Bacitracin
Entry
D00128                      Drug                                   

Name
Bacitracin (JP17/USP/INN);
Baciim (TN);
Bacitracin (TN)
Product
  Generic
Component
Bacitracin A [CPD:C15482]
Source
Bacillus licheniformis [TAX:1402]
Class
Antibacterial
 DG01579  Polypeptide antibiotic
Remark
Same as: C01667
ATC code: D06AX05 J01XX10 R02AB04
Chemical structure group: DG00400
Product (DG00400): D00128<US>
Product (mixture): D04755<JP>
Efficacy
Antibacterial, Cell membrane function inhibitor
  Disease
Staphylococcal infection [DS:H01175]
Comment
Natural product
Polypeptide
Bacitracin A [CPD:C15482] is the major component of Bacitracin.
Target
undecaprenyl-diphosphate phosphatase [KO:K06153 K19302]
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Other map
map01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX05 Bacitracin
      D00128  Bacitracin (JP17/USP/INN) <US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XX Other antibacterials
     J01XX10 Bacitracin
      D00128  Bacitracin (JP17/USP/INN) <US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AB Antibiotics
     R02AB04 Bacitracin
      D00128  Bacitracin (JP17/USP/INN) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Bacitracin
    D00128  Bacitracin (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Bacitracin
     D00128  Bacitracin (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D00128  Bacitracin (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Bacitracin
    D00128  Bacitracin (JP17/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell membrane function inhibitor
   Polypeptide
    D00128  Bacitracin (JP17/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00128  Bacitracin
Other DBs
CAS: 1405-87-4
PubChem: 7847196
ChEBI: 28669
DrugBank: DB00626
NIKKAJI: J5.143H
LinkDB

» Japanese version   » Back

KEGG   DRUG: Vancomycin
Entry
D00212                      Drug                                   

Name
Vancomycin (USP);
Vancocin (TN)
Formula
C66H75Cl2N9O24
Exact mass
1447.4302
Mol weight
1449.2536
Structure
Simcomp
Source
Amycolatopsis orientalis [TAX:31958], Streptomyces orientalis [TAX:31958]
Class
Antibacterial
 DG01580  Glycopeptide antibiotic
Remark
Same as: C06689
ATC code: A07AA09 J01XA01 S01AA28
Chemical structure group: DG00086
Product (DG00086): D00926<JP/US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Comment
Natural product
Glycopeptide
Vancomycin makes complex formation with D-alanyl-D-alanine of Peptidoglycan, and inhibites cross-link between protein and peptideglycan.
Target
peptidoglycan (D-Ala-D-Ala)
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
Other map
map01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA09 Vancomycin
      D00212  Vancomycin (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XA Glycopeptide antibacterials
     J01XA01 Vancomycin
      D00212  Vancomycin (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA28 Vancomycin
      D00212  Vancomycin (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, other
   Glycopeptide
    D00212  Vancomycin (USP)
Other DBs
CAS: 1404-90-6
PubChem: 7847279
ChEBI: 28001
ChEMBL: CHEMBL262777 CHEMBL3735877
DrugBank: DB00512
LigandBox: D00212
NIKKAJI: J34.275K
LinkDB
KCF data

ATOM        101
            1   C1y C    22.1523  -23.0181
            2   C1x C    22.1616  -21.6755
            3   O2x O    23.3049  -23.6865
            4   C1z C    23.3233  -21.0234
            5   C1y C    24.4667  -23.0342
            6   C1y C    24.4759  -21.6916
            7   C1a C    22.3951  -19.9369
            8   N1a N    24.2867  -19.9500
            9   C1a C    25.6267  -23.7026
            10  O1a O    25.6451  -21.0396
            11  C8y C    19.9288  -18.7446
            12  C8y C    21.0859  -18.0770
            13  C8y C    18.7713  -18.0843
            14  O2a O    19.9371  -20.0799
            15  C8x C    21.0786  -16.7343
            16  O2x O    22.2358  -18.7373
            17  C8x C    18.7640  -16.7491
            18  O2x O    17.6068  -18.7373
            19  C1y C    18.7766  -21.8455
            20  C8y C    19.9139  -16.0667
            21  C8y C    23.4004  -18.0696
            22  C8y C    16.4420  -18.0770
            23  C1y C    18.7766  -23.1881
            24  O2x O    17.6121  -21.1779
            25  C1y C    19.9467  -13.9511
            26  C8y C    23.4004  -16.7343
            27  C8x C    24.5577  -18.7298
            28  C8y C    15.2849  -18.7373
            29  C8x C    16.4346  -16.7343
            30  C1y C    17.6268  -23.8707
            31  C1y C    16.4474  -21.8604
            32  C5x C    21.0265  -13.2760
            33  N1x N    18.7270  -13.2833
            34  C8x C    24.5577  -16.0591
            35  X   Cl   22.2358  -16.0518
            36  C8x C    25.7075  -18.0696
            37  C8x C    14.1275  -18.0843
            38  X   Cl   15.2774  -20.0726
            39  C8x C    15.2701  -16.0667
            40  C1y C    16.4546  -23.2105
            41  O1a O    17.6194  -25.1986
            42  N1x N    22.1913  -13.9511
            43  O5x O    21.0192  -11.9407
            44  C5x C    17.5695  -13.9584
            45  C8y C    25.7075  -16.7343
            46  C8y C    14.1203  -16.7491
            47  O1a O    15.2899  -23.8632
            48  C1y C    23.3411  -13.2760
            49  C1y C    16.4124  -13.2909
            50  O5x O    17.5623  -15.2937
            51  C1y C    26.8574  -16.0518
            52  C1y C    12.9555  -16.0667
            53  C8y C    23.2785  -11.9407
            54  C5x C    24.4983  -13.9435
            55  N1x N    15.2552  -13.9660
            56  C1y C    26.8499  -13.9511
            57  O1a O    28.0146  -16.7270
            58  C1y C    12.9481  -13.9733
            59  O1a O    11.7908  -16.7343
            60  C8x C    24.5058  -11.2729
            61  C8x C    22.1840  -11.2729
            62  N1x N    25.6554  -13.2685
            63  C5x C    14.1054  -13.2982
            64  C5x C    28.0073  -13.2760
            65  N1b N    11.7834  -13.3057
            66  C8y C    24.5058   -9.9303
            67  C8x C    22.1840   -9.9376
            68  O5x O    14.1678  -11.9629
            69  N1x N    27.9998  -11.9407
            70  O5x O    29.1645  -13.9511
            71  C5a C    10.6261  -13.9660
            72  C8y C    25.6703   -9.2774
            73  C8y C    23.3411   -9.2625
            74  C1y C    26.8350  -11.2729
            75  C1c C     9.4688  -13.2982
            76  O5a O    10.6187  -15.3010
            77  C8y C    26.8277   -9.9376
            78  C8y C    25.6630   -7.9347
            79  C6a C    29.0755   -9.9897
            80  C1b C     9.4615  -11.9629
            81  N1b N     8.3041  -13.9584
            82  C8x C    27.9849   -9.2625
            83  C8x C    26.8129   -7.2596
            84  O1a O    24.4983   -7.2596
            85  C8y C    27.9776   -7.9198
            86  O1a O    29.1273   -7.2375
            87  O5x O    24.5017  -15.3103
            88  O1a O    23.3357   -7.8673
            89  O6a O    30.2660  -10.6825
            90  O6a O    29.0800   -8.6255
            91  C1a C     8.3012  -15.3102
            92  C1c C     8.2758  -11.2878
            93  C1a C     7.0582  -12.0004
            94  C1a C     8.2672   -9.9349
            95  C1b C    16.4087  -11.1067
            96  C5a C    17.5830  -10.4243
            97  N1a N    18.7559  -11.0972
            98  O5a O    17.5793   -9.0391
            99  C1b C    15.2538  -21.1805
            100 O1a O    14.0910  -21.8612
            101 O2a O    20.3945  -23.8738
BOND        110
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1 #Up
            7     4   8 1 #Down
            8     5   9 1 #Down
            9     6  10 1 #Down
            10    5   6 1
            11   11  12 1
            12   11  13 2
            13   11  14 1
            14   12  15 2
            15   12  16 1
            16   13  17 1
            17   13  18 1
            18   19  14 1 #Up
            19   15  20 1
            20   16  21 1
            21   18  22 1
            22   19  23 1
            23   19  24 1
            24   20  25 1
            25   21  26 1
            26   21  27 2
            27   22  28 1
            28   22  29 2
            29   23  30 1
            30   24  31 1
            31   25  32 1
            32   25  33 1 #Up
            33   26  34 2
            34   26  35 1
            35   27  36 1
            36   28  37 2
            37   28  38 1
            38   29  39 1
            39   30  40 1
            40   30  41 1 #Up
            41   32  42 1
            42   32  43 2
            43   33  44 1
            44   34  45 1
            45   37  46 1
            46   40  47 1 #Down
            47   42  48 1
            48   44  49 1
            49   44  50 2
            50   45  51 1
            51   46  52 1
            52   48  53 1
            53   48  54 1 #Down
            54   49  55 1
            55   51  56 1
            56   51  57 1 #Down
            57   52  58 1
            58   52  59 1 #Up
            59   53  60 1
            60   53  61 2
            61   54  62 1
            62   55  63 1
            63   56  64 1
            64   58  65 1 #Up
            65   60  66 2
            66   61  67 1
            67   63  68 2
            68   64  69 1
            69   64  70 2
            70   65  71 1
            71   66  72 1
            72   66  73 1
            73   69  74 1
            74   71  75 1
            75   71  76 2
            76   72  77 2
            77   72  78 1
            78   74  79 1 #Down
            79   75  80 1
            80   75  81 1 #Down
            81   77  82 1
            82   78  83 2
            83   78  84 1
            84   82  85 2
            85   85  86 1
            86   17  20 2
            87   31  40 1
            88   36  45 2
            89   39  46 2
            90   56  62 1 #Down
            91   58  63 1
            92   67  73 2
            93   74  77 1
            94   83  85 1
            95   54  87 2
            96   73  88 1
            97   79  89 1
            98   79  90 2
            99   81  91 1
            100  80  92 1
            101  92  93 1
            102  92  94 1
            103  49  95 1 #Up
            104  95  96 1
            105  96  97 1
            106  96  98 2
            107  31  99 1 #Up
            108  99 100 1
            109  23 101 1 #Down
            110   1 101 1 #Up

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KEGG   COMPOUND: C15922
Entry
C15922                      Compound                               

Name
Indolicidin
Sequence
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg-NH2
  Organism
Bos taurus [BTA:282166]
  Type
Peptide
Pathway
map01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
Bioactive peptides [BR:br08005]
 Others
  Microbicidal and cytotoxic peptide
   C15922  Indolicidin
Other DBs
CAS: 140896-21-5
PubChem: 47205240
ChEBI: 80180
NIKKAJI: J652.745K
LinkDB

» Japanese version

KEGG   COMPOUND: C18313
Entry
C18313                      Compound                               

Name
LL-37;
Cathelicidin LL-37
Sequence
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu
Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val
Pro Arg Thr Glu Ser
  Organism
Homo sapiens [HSA:820]
  Type
Peptide
Pathway
map01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
Bioactive peptides [BR:br08005]
 Others
  Microbicidal and cytotoxic peptide
   C18313  Cathelicidin LL-37
Other DBs
PubChem: 103061495
ChEBI: 81664
LinkDB

» Japanese version

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