KEGG   DRUG: FluticasoneHelp
Entry
D07981                      Drug                                   

Name
Fluticasone (INN);
Fluticaps (TN)
Formula
C22H27F3O4S
Exact mass
444.1582
Mol weight
444.5076
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C07815
ATC code: D07AC17 R01AD08 R03BA05
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D07981  Fluticasone (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D07981  Fluticasone (INN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D07981  Fluticasone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07981  Fluticasone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07981
BRITE hierarchy
Other DBs
CAS: 90566-53-3
PubChem: 96024676
ChEBI: 5134
ChEMBL: CHEMBL1201396
LigandBox: D07981
NIKKAJI: J22.755B
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2x C    19.5739  -28.3860
            2   C5x C    19.5739  -29.7339
            3   C2x C    20.7799  -30.4434
            4   C2y C    21.9150  -29.7339
            5   C1z C    21.9150  -28.3860
            6   C2x C    20.7799  -27.7475
            7   C1y C    23.1211  -30.4434
            8   C1x C    24.3271  -29.7339
            9   C1y C    24.3271  -28.3860
            10  C1z C    23.1211  -27.7475
            11  C1y C    25.3913  -27.7475
            12  C1z C    25.3913  -26.3996
            13  C1x C    24.3271  -25.6901
            14  C1y C    23.1211  -26.3996
            15  C1x C    27.7324  -27.7475
            16  C1y C    27.7324  -26.3996
            17  C1z C    26.5264  -25.6901
            18  O5x O    18.4388  -30.4434
            19  C1a C    21.9150  -27.0381
            20  X   F    23.1211  -29.0245
            21  O1a O    21.9150  -25.6901
            22  C1a C    25.3913  -24.9807
            23  O1a O    27.9452  -24.7679
            24  C1a C    29.1513  -26.3996
            25  X   F    23.1211  -31.8622
            26  C5a C    26.5264  -24.2713
            27  O5a O    27.7551  -23.5618
            28  S2a S    25.2976  -23.5618
            29  C1b C    24.0860  -24.2615
            30  X   F    22.8826  -23.5668
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1

» Japanese version   » Back

KEGG   DRUG: Fluticasone propionateHelp
Entry
D01708                      Drug                                   

Name
Fluticasone propionate (JAN/USP);
Cutivate (TN);
Flonase (TN);
Flovent (TN)
Product
  Generic
FLUTICASONE (Direct RX), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (DIRECT RX), FLUTICASONE PROPIONATE (Direct_RX), FLUTICASONE PROPIONATE (Doc Rx), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (Glenmark Pharmaceuticals), FLUTICASONE PROPIONATE (Golden State Medical Supply), FLUTICASONE PROPIONATE (Hi-Tech Pharmacal), FLUTICASONE (Lake Erie Medical DBA Quality Care Products LLC), BESER (Medimetriks Pharmaceuticals), BESER (Medimetriks Pharmaceuticals), FLUTICASONE (Morton Grove Pharmaceuticals), FLUTICASONE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Perrigo New York), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), TICANASE (PureTek Corporation), FLUTICASONE PROPIONATE (Quality Care Products), FLUTICASONE PROPIONATE (Taro Pharmaceuticals U.S.A.), FLUTICASONE (Unit Dose Services), FLUTICASONE PROPIONATE (West-Ward Pharmaceuticals Corp.)
Formula
C25H31F3O5S
Exact mass
500.1844
Mol weight
500.5709
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1329 2290
ATC code: D07AC17 R01AD08 R03BA05
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Product (mixture): D08699<JP/US> D10506<JP> D11656<US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Fluticasone
     D01708  Fluticasone propionate (JAN/USP)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Fluticasone
    D01708  Fluticasone propionate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D01708  Fluticasone propionate (JAN/USP)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D01708  Fluticasone propionate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Drugs requiring guidance
  New approved switch OTC drugs
   Fluticasone propionate
    D01708  Fluticasone propionate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01708  Fluticasone propionate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01708
Topical steroids potency [br08317.html]
 Classification in the USA
  D01708
Rx-to-OTC switch list in the USA [br08315.html]
 D01708
BRITE hierarchy
Other DBs
CAS: 80474-14-2
PubChem: 7848771
ChEBI: 31441
ChEMBL: CHEMBL1473 CHEMBL3182902
DrugBank: DB00588
LigandBox: D01708
NIKKAJI: J457.058H
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C    19.6000  -28.4200
            2   C5x C    19.6000  -29.7500
            3   C2x C    20.7900  -30.4500
            4   C2y C    21.9100  -29.7500
            5   C1z C    21.9100  -28.4200
            6   C2x C    20.7900  -27.7200
            7   C1y C    23.1000  -30.4500
            8   C1x C    24.3600  -29.7500
            9   C1y C    24.3600  -28.4200
            10  C1z C    23.1000  -27.7200
            11  C1y C    25.4100  -27.7200
            12  C1z C    25.4100  -26.3900
            13  C1x C    24.3600  -25.6900
            14  C1y C    23.1000  -26.3900
            15  C1x C    27.7200  -27.7200
            16  C1y C    27.7200  -26.3900
            17  C1z C    26.5300  -25.6900
            18  O5x O    18.4100  -30.4500
            19  C1a C    21.9100  -27.0200
            20  X   F    23.1000  -29.0500
            21  O1a O    21.9100  -25.6900
            22  C1a C    25.4100  -24.9900
            23  O7a O    27.9300  -24.7800
            24  C1a C    29.1200  -26.3900
            25  X   F    23.1000  -31.8500
            26  C5a C    26.5300  -24.2900
            27  O5a O    27.7900  -23.5900
            28  S2a S    25.2700  -23.5900
            29  C1b C    24.0800  -24.2900
            30  X   F    22.8900  -23.5900
            31  C7a C    29.1200  -24.0800
            32  C1b C    30.3100  -24.7800
            33  C1a C    31.5000  -24.0800
            34  O6a O    29.1200  -22.6800
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1
            34   31  32 1
            35   31  23 1
            36   32  33 1
            37   31  34 2

» Japanese version   » Back

KEGG   DRUG: Fluticasone furoateHelp
Entry
D06315                      Drug                                   

Name
Fluticasone furoate (JAN/USAN/INN);
Veramyst (TN)
Product
Formula
C27H29F3O6S
Exact mass
538.1637
Mol weight
538.5758
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1329 2290
ATC code: D07AC17 R01AD08 R01AD12 R03BA05 R03BA09
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Product (mixture): D10501<JP/US> D11035<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Allergic rhinitis [DS:H01360]
Asthma [DS:H00079]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
     R01AD12 Fluticasone furoate
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
     R03BA09 Fluticasone furoate
      D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Fluticasone
     D06315  Fluticasone furoate (JAN/USAN/INN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Fluticasone
    D06315  Fluticasone furoate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D06315  Fluticasone furoate (JAN/USAN/INN)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D06315  Fluticasone furoate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D06315  Fluticasone furoate (JAN/USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06315
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06315
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06315
Rx-to-OTC switch list in the USA [br08315.html]
 D06315
BRITE hierarchy
Other DBs
CAS: 397864-44-7
PubChem: 47207972
ChEBI: 74899
ChEMBL: CHEMBL1676
PDB-CCD: GW6[PDBj]
LigandBox: D06315
LinkDB All DBs
KCF data Show

ATOM        37
            1   C2x C    19.6000  -28.4200
            2   C5x C    19.6000  -29.7500
            3   C2x C    20.7900  -30.4500
            4   C2y C    21.9100  -29.7500
            5   C1z C    21.9100  -28.4200
            6   C2x C    20.7900  -27.7200
            7   C1y C    23.1000  -30.4500
            8   C1x C    24.3600  -29.7500
            9   C1y C    24.3600  -28.4200
            10  C1z C    23.1000  -27.7200
            11  C1y C    25.4100  -27.7200
            12  C1z C    25.4100  -26.3900
            13  C1x C    24.3600  -25.6900
            14  C1y C    23.1000  -26.3900
            15  C1x C    27.7200  -27.7200
            16  C1y C    27.7200  -26.3900
            17  C1z C    26.5300  -25.6900
            18  O5x O    18.4100  -30.4500
            19  C1a C    21.9100  -27.0200
            20  X   F    23.1000  -29.0500
            21  O1a O    21.9100  -25.6900
            22  C1a C    25.4100  -24.9900
            23  O7a O    27.9300  -24.7800
            24  C1a C    29.1200  -26.3900
            25  X   F    23.1000  -31.8500
            26  C5a C    26.5300  -24.2900
            27  O5a O    27.7900  -23.5900
            28  S2a S    25.2700  -23.5900
            29  C1b C    24.0800  -24.2900
            30  X   F    22.8900  -23.5900
            31  C7a C    29.1200  -24.0800
            32  C8y C    30.3100  -24.7800
            33  O6a O    29.1200  -22.6800
            34  C8x C    30.8000  -26.1100
            35  C8x C    32.2000  -26.1100
            36  C8x C    32.6200  -24.7800
            37  O2x O    31.4300  -23.9400
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1
            34   31  32 1
            35   31  23 1
            36   31  33 2
            37   32  34 2
            38   34  35 1
            39   35  36 2
            40   36  37 1
            41   32  37 1

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