KEGG   DRUG: Hydromorphone
Entry
D08047                      Drug                                   

Name
Hydromorphone (INN)
Formula
C17H19NO3
Exact mass
285.1365
Mol weight
285.3377
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Same as: C07042
ATC code: N02AA03
Chemical structure group: DG00811
Product (DG00811): D00839<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA03 Hydromorphone
      D08047  Hydromorphone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08047  Hydromorphone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08047
Other DBs
CAS: 466-99-9
PubChem: 96024740
ChEBI: 5790
ChEMBL: CHEMBL398707
DrugBank: DB00327
LigandBox: D08047
NIKKAJI: J5.904H
LinkDB
KCF data

ATOM        21
            1   C1z C    23.0300  -18.6200
            2   C8y C    23.0300  -17.2900
            3   C1y C    24.2200  -19.2500
            4   C1y C    21.9100  -19.1800
            5   C1x C    24.2200  -17.9900
            6   C8y C    21.9100  -16.6600
            7   C8y C    24.2200  -16.6600
            8   C1y C    25.3400  -18.6200
            9   C1x C    24.2200  -20.5100
            10  O2x O    20.5800  -17.9200
            11  C5x C    21.9100  -20.5100
            12  C1x C    26.3900  -17.9900
            13  C8y C    21.9100  -15.3300
            14  C1x C    25.3400  -17.3600
            15  C8x C    24.2200  -15.3300
            16  N1y N    26.3900  -19.2500
            17  C1x C    23.0300  -21.2100
            18  O5x O    20.7900  -21.2100
            19  C8x C    23.1000  -14.7000
            20  O1a O    20.7900  -14.7000
            21  C1a C    27.7900  -19.2500
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25   16  21 1

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KEGG   DRUG: Hydromorphone hydrochloride
Entry
D00839                      Drug                                   

Name
Hydromorphone hydrochloride (JAN/USP);
Dilaudid (TN);
Exalgo (TN);
Palladone (TN)
Product
  Generic
HYDROMORPHONE HYDROCHLORIDE (Akorn), HYDROMORPHONE HYDROCHLORIDE (American Health Packaging), HYDROMORPHONE HYDROCHLORIDE (Ascent Pharmaceuticals), HYDROMORPHONE HYDROCHLORIDE (Aurolife Pharma), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Camber Pharmaceuticals), HYDROMORPHONE HYDROCHLORIDE (Elite Laboratories), HYDROMORPHONE HYDROCHLORIDE (Hospira), HYDROMORPHONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDROMORPHONE HYDROCHLORIDE (Lannett Company), HYDROMORPHONE HYDROCHLORIDE (Lannett Company), HYDROMORPHONE HYDROCHLORIDE (Lohxa), HYDROMORPHONE HYDROCHLORIDE (Paddock Laboratories), HYDROMORPHONE HYDROCHLORIDE (RedPharm Drug), HYDROMORPHONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), HYDROMORPHONE HYDROCHLORIDE (SpecGx LLC), HYDROMORPHONE HYDROCHLORIDE (SpecGx LLC), HYDROMORPHONE HYDROCHLORIDE (Teva Parenteral Medicines), HYDROMORPHONE HYDROCHLORIDE (Trigen Laboratories), HYDROMORPHONE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), HYDROMORPHONE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
Formula
C17H19NO3. HCl
Exact mass
321.1132
Mol weight
321.7986
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Remark
Therapeutic category: 8119
ATC code: N02AA03
Chemical structure group: DG00811
Product (DG00811): D00839<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA03 Hydromorphone
      D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
  Opioid Analgesics, Short-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8119  Others
     D00839  Hydromorphone hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00839
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00839
Other DBs
CAS: 71-68-1
PubChem: 7847904
ChEBI: 5791
ChEMBL: CHEMBL1237055
DrugBank: DB00327
LigandBox: D00839
NIKKAJI: J252.891F
LinkDB
KCF data

ATOM        22
            1   X   Cl   33.7684  -12.5160
            2   C1z C    26.4194  -13.3594
            3   C8y C    26.4194  -12.0354
            4   C1y C    27.6040  -14.0561
            5   C1y C    25.3045  -13.9865
            6   C1x C    27.6040  -12.7323
            7   C8y C    25.3045  -11.4083
            8   C8y C    27.6040  -11.4083
            9   C1y C    28.7189  -13.3594
            10  C1x C    27.6040  -15.3104
            11  O2x O    23.9806  -12.6625
            12  C5x C    25.3045  -15.3104
            13  C1x C    29.8337  -12.7323
            14  C8y C    25.3045  -10.0844
            15  C1x C    28.7189  -12.1051
            16  C8x C    27.6040  -10.0844
            17  N1y N    29.8337  -14.0561
            18  C1x C    26.4194  -16.0072
            19  O5x O    24.1897  -16.0072
            20  C8x C    26.4891   -9.4573
            21  O1a O    24.1897   -9.4573
            22  C1a C    31.2326  -14.0561
BOND        25
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     4  10 1
            9     5  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    7  14 1
            13    8  15 1
            14    8  16 2
            15    9  17 1 #Up
            16   10  18 1
            17   12  19 2
            18   14  20 2
            19   14  21 1
            20    7  11 1
            21    9  15 1
            22   12  18 1
            23   13  17 1
            24   16  20 1
            25   17  22 1

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