KEGG   DRUG: MosaprideHelp
Entry
D08236                      Drug                                   

Name
Mosapride (INN);
Mosart (TN)
Formula
C21H25ClFN3O3
Exact mass
421.1568
Mol weight
421.8929
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01763  Propulsive
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: A03FA09
Chemical structure group: DG01285
Product (DG01285): D01994<JP>
Efficacy
Prokinetic, Serotonin receptor agonist
Target
HTR4 [HSA:3360] [KO:K04160]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03F PROPULSIVES
    A03FA Propulsives
     A03FA09 Mosapride
      D08236  Mosapride (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR4
     D08236  Mosapride (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08236
BRITE hierarchy
Other DBs
CAS: 112885-41-3
PubChem: 96024924
ChEMBL: CHEMBL60889
LigandBox: D08236
NIKKAJI: J245.710E
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8y C    11.3400  -16.1700
            2   C8y C    11.3400  -14.7700
            3   C8x C    12.6000  -14.0700
            4   C8y C    13.7900  -14.7700
            5   C8y C    13.7900  -16.1700
            6   C8x C    12.6000  -16.8700
            7   C5a C    14.9800  -16.8700
            8   N1b N    16.2400  -16.1700
            9   C1b C    17.4300  -16.8700
            10  C1y C    18.6200  -16.1700
            11  O2x O    18.6200  -14.7700
            12  C1x C    19.8800  -14.0700
            13  C1x C    21.0700  -14.7700
            14  N1y N    21.0700  -16.1700
            15  C1x C    19.8800  -16.8700
            16  O2a O    14.9800  -14.0700
            17  C1b C    16.2400  -14.7700
            18  C1a C    17.4300  -14.0700
            19  X   Cl   10.1500  -16.8700
            20  N1a N    10.1500  -14.0700
            21  O5a O    14.9800  -18.2700
            22  C1b C    22.2600  -16.8700
            23  C8y C    23.5200  -16.1700
            24  C8x C    23.5200  -14.7700
            25  C8x C    24.7100  -14.0700
            26  C8y C    25.9000  -14.7700
            27  C8x C    25.9000  -16.1700
            28  C8x C    24.7100  -16.8700
            29  X   F    27.1600  -14.0700
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   10  15 1
            17    4  16 1
            18   16  17 1
            19   17  18 1
            20    1  19 1
            21    2  20 1
            22    7  21 2
            23   14  22 1
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 2
            30   23  28 1
            31   26  29 1

» Japanese version   » Back

KEGG   DRUG: Mosapride citrate hydrateHelp
Entry
D01994                      Drug                                   

Name
Mosapride citrate hydrate (JP17);
Mosapride citrate dihydrate;
Gasmotin (TN)
Formula
C21H25ClFN3O3. C6H8O7. 2H2O
Exact mass
649.205
Mol weight
650.047
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01763  Propulsive
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C13494
Therapeutic category: 2399
ATC code: A03FA09
Chemical structure group: DG01285
Product (DG01285): D01994<JP>
Efficacy
Prokinetic, Serotonin receptor agonist
Target
HTR4 [HSA:3360] [KO:K04160]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03F PROPULSIVES
    A03FA Propulsives
     A03FA09 Mosapride
      D01994  Mosapride citrate hydrate (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D01994  Mosapride citrate hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR4
     D01994  Mosapride citrate hydrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01994  Mosapride citrate hydrate
  D01994  Mosapride citrate tablets
  D01994  Mosapride citrate powder
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01994
BRITE hierarchy
Other DBs
CAS: 636582-62-2
PubChem: 7849056
ChEBI: 31867
LigandBox: D01994
LinkDB All DBs
KCF data Show

ATOM        44
            1   C1d C    22.8158  -18.4544
            2   C1b C    21.6014  -19.1548
            3   C1b C    24.0300  -19.1548
            4   C6a C    23.5163  -17.2400
            5   O1a O    22.1152  -17.2400
            6   C6a C    20.3871  -18.5010
            7   C6a C    24.0300  -20.5560
            8   O6a O    22.8158  -16.0258
            9   O6a O    24.9173  -17.2400
            10  O6a O    19.1729  -19.2016
            11  O6a O    20.3871  -17.1000
            12  O6a O    25.2443  -21.2565
            13  O6a O    22.8158  -21.2565
            14  O0  O    14.7000  -18.8300
            15  C8y C    10.7100  -13.1600
            16  C8y C    10.7100  -11.7600
            17  C8x C    11.9700  -11.0600
            18  C8y C    13.1600  -11.7600
            19  C8y C    13.1600  -13.1600
            20  C8x C    11.9700  -13.8600
            21  C5a C    14.3500  -13.8600
            22  N1b N    15.6100  -13.1600
            23  C1b C    16.8000  -13.8600
            24  C1y C    17.9900  -13.1600
            25  O2x O    17.9900  -11.7600
            26  C1x C    19.2500  -11.0600
            27  C1x C    20.4400  -11.7600
            28  N1y N    20.4400  -13.1600
            29  C1x C    19.2500  -13.8600
            30  O2a O    14.3500  -11.0600
            31  C1b C    15.6100  -11.7600
            32  C1a C    16.8000  -11.0600
            33  X   Cl    9.5200  -13.8600
            34  N1a N     9.5200  -11.0600
            35  O5a O    14.3500  -15.2600
            36  C1b C    21.6300  -13.8600
            37  C8y C    22.8900  -13.1600
            38  C8x C    22.8900  -11.7600
            39  C8x C    24.0800  -11.0600
            40  C8y C    25.2700  -11.7600
            41  C8x C    25.2700  -13.1600
            42  C8x C    24.0800  -13.8600
            43  X   F    26.5300  -11.0600
            44  O0  O    14.7000  -18.8300
BOND        43
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   15  16 2
            14   16  17 1
            15   17  18 2
            16   18  19 1
            17   19  20 2
            18   15  20 1
            19   19  21 1
            20   21  22 1
            21   22  23 1
            22   23  24 1
            23   24  25 1
            24   25  26 1
            25   26  27 1
            26   27  28 1
            27   28  29 1
            28   24  29 1
            29   18  30 1
            30   30  31 1
            31   31  32 1
            32   15  33 1
            33   16  34 1
            34   21  35 2
            35   28  36 1
            36   36  37 1
            37   37  38 2
            38   38  39 1
            39   39  40 2
            40   40  41 1
            41   41  42 2
            42   37  42 1
            43   40  43 1
BRACKET     1    12.3200  -19.8800   12.3200  -17.8500
            1    15.4700  -17.8500   15.4700  -19.8800
            1  2
 ORIGINAL  1   14
 REPEAT    1   44

» Japanese version   » Back

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