KEGG   DRUG: Nafamostat
Entry
D08240                      Drug                                   

Name
Nafamostat (INN)
Formula
C19H17N5O2
Exact mass
347.1382
Mol weight
347.3706
Structure
Class
Cardiovascular agent
 DG01990  Serine protease inhibitor
 DG02012  Antifibrinolytic
  DG01990  Serine protease inhibitor
 DG02016  Hemostatics
  DG02012  Antifibrinolytic
   DG01990  Serine protease inhibitor
Remark
Chemical structure group: DG01896
Product (DG01896): D01670<JP>
Efficacy
Anticoagulant, Antifibrinolytic, Serine protease inhibitor
Target
serine proteases
Interaction
Structure map
map07114  Naphthalene family
Other DBs
CAS: 81525-10-2
PubChem: 96024928
ChEMBL: CHEMBL273264
LigandBox: D08240
NIKKAJI: J33.163E
LinkDB
KCF data

ATOM        26
            1   C8y C    29.2600  -16.6600
            2   C8x C    30.4500  -15.9600
            3   C8x C    31.6400  -16.6600
            4   C8y C    31.6400  -18.0600
            5   C8x C    30.4500  -18.7600
            6   C8y C    29.2600  -18.0600
            7   C7a C    24.3600  -16.6600
            8   O7a O    25.6200  -15.9600
            9   C8y C    26.8100  -16.6600
            10  C8x C    28.0000  -15.9600
            11  C8x C    28.0000  -18.7600
            12  C8x C    26.8100  -18.0600
            13  O6a O    24.3600  -18.0600
            14  C2c C    32.9000  -18.7600
            15  N2a N    34.0900  -18.0600
            16  N1a N    32.9000  -20.1600
            17  C8y C    23.1700  -15.9600
            18  C8x C    20.7200  -15.9600
            19  C8y C    20.7200  -14.5600
            20  C8x C    21.9800  -13.8600
            21  C8x C    23.1700  -14.5600
            22  C8x C    21.9800  -16.6600
            23  N1b N    19.5300  -13.8600
            24  C2c C    18.3400  -14.5600
            25  N2a N    17.0800  -13.8600
            26  N1a N    18.3400  -15.9600
BOND        28
            1     7  17 1
            2     7   8 1
            3     8   9 1
            4     1   2 2
            5     2   3 1
            6    18  19 2
            7    19  20 1
            8    20  21 2
            9    21  17 1
            10   17  22 2
            11   22  18 1
            12    3   4 2
            13   19  23 1
            14    9  10 2
            15   23  24 1
            16   10   1 1
            17   24  25 2
            18    6  11 1
            19   24  26 1
            20   11  12 2
            21   12   9 1
            22    4   5 1
            23    7  13 2
            24    5   6 2
            25    4  14 1
            26    6   1 1
            27   14  15 2
            28   14  16 1

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KEGG   DRUG: Nafamostat mesylate
Entry
D01670                      Drug                                   

Name
Nafamostat mesylate (USAN);
Nafamostat mesilate (JP17);
Ronastat (TN)
Formula
C19H17N5O2. (CH4SO3)2
Exact mass
539.1145
Mol weight
539.5819
Structure
Simcomp
Class
Cardiovascular agent
 DG01990  Serine protease inhibitor
 DG02012  Antifibrinolytic
  DG01990  Serine protease inhibitor
 DG02016  Hemostatics
  DG02012  Antifibrinolytic
   DG01990  Serine protease inhibitor
Remark
Therapeutic category: 3999
Chemical structure group: DG01896
Product (DG01896): D01670<JP>
Efficacy
Anticoagulant, Antifibrinolytic, Serine protease inhibitor
Target
serine proteases
Interaction
Structure map
map07049  Antithrombosis agents
map07114  Naphthalene family
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01670  Nafamostat mesylate (USAN); Nafamostat mesilate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01670  Nafamostat mesilate
Other DBs
CAS: 82956-11-4
PubChem: 7848733
ChEBI: 31890
ChEMBL: CHEMBL3989553
LigandBox: D01670
NIKKAJI: J252.816I
LinkDB
KCF data

ATOM        36
            1   C8y C    37.1397  -15.9144
            2   C8x C    38.3496  -15.2138
            3   C8x C    39.5613  -15.9115
            4   C8y C    39.5630  -17.3096
            5   C8x C    38.3530  -18.0102
            6   C8y C    37.1414  -17.3125
            7   C7a C    32.2951  -15.9135
            8   O7a O    33.5077  -15.2120
            9   C8y C    34.7216  -15.9116
            10  C8x C    35.9310  -15.2099
            11  C8x C    35.9330  -18.0120
            12  C8x C    34.7191  -17.3123
            13  O6a O    32.2962  -17.3146
            14  C2c C    40.7772  -18.0086
            15  N2a N    41.9896  -17.3067
            16  N1a N    40.7789  -19.4096
            17  C8y C    31.0812  -15.2138
            18  C8x C    28.6560  -15.2138
            19  C8y C    28.6560  -13.8129
            20  C8x C    29.8722  -13.1124
            21  C8x C    31.0812  -13.8129
            22  C8x C    29.8722  -15.9144
            23  N1b N    27.4430  -13.1117
            24  C2c C    26.2294  -13.8117
            25  N2a N    25.0164  -13.1105
            26  N1a N    26.2286  -15.2126
            27  S4a S    26.1059  -19.0059
            28  C1a C    24.7105  -19.0351
            29  O1d O    27.5016  -19.0701
            30  O1d O    26.1059  -17.5988
            31  O1d O    26.1002  -20.4072
            32  S4a S    26.1059  -19.0059
            33  C1a C    24.7105  -19.0351
            34  O1d O    27.5016  -19.0701
            35  O1d O    26.1059  -17.5988
            36  O1d O    26.1002  -20.4072
BOND        36
            1     7  17 1
            2     7   8 1
            3     8   9 1
            4     1   2 2
            5     2   3 1
            6    18  19 2
            7    19  20 1
            8    20  21 2
            9    21  17 1
            10   17  22 2
            11   22  18 1
            12    3   4 2
            13   19  23 1
            14    9  10 2
            15   23  24 1
            16   10   1 1
            17   24  25 2
            18    6  11 1
            19   24  26 1
            20   11  12 2
            21   12   9 1
            22    4   5 1
            23    7  13 2
            24    5   6 2
            25    4  14 1
            26    6   1 1
            27   14  15 2
            28   14  16 1
            29   27  28 1
            30   27  29 1
            31   27  30 2
            32   27  31 2
            33   32  33 1
            34   32  34 1
            35   32  35 2
            36   32  36 2
BRACKET     1    22.4700  -21.2800   22.4700  -16.5900
            1    28.8400  -16.5900   28.8400  -21.2800
            1  2
 ORIGINAL  1   27  28  29  30  31
 REPEAT    1   32  33  34  35  36

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