KEGG   DRUG: Nalorphine
Entry
D08247                      Drug                                   

Name
Nalorphine (INN);
Nalorphine serb (TN)
Formula
C19H21NO3
Exact mass
311.1521
Mol weight
311.3749
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
Same as: C11787
ATC code: V03AB02
Chemical structure group: DG01151
Efficacy
Antidote (morphine), Opioid receptor agonist/antagonist
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB02 Nalorphine
      D08247  Nalorphine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08247  Nalorphine (INN)
    OPRK1
     D08247  Nalorphine (INN)
Other DBs
CAS: 62-67-9
PubChem: 96024935
ChEBI: 7458
ChEMBL: CHEMBL415284
LigandBox: D08247
NIKKAJI: J4.825I
LinkDB
KCF data

ATOM        23
            1   C1z C    21.4229  -28.4328
            2   C8y C    21.4229  -27.1069
            3   C1y C    22.5394  -29.0608
            4   C1y C    20.3063  -29.0608
            5   C1x C    22.3999  -27.4558
            6   C8y C    20.3063  -26.4090
            7   C8y C    22.5394  -26.4090
            8   C1y C    23.7258  -28.4328
            9   C2x C    22.5394  -30.3868
            10  O2x O    19.2596  -27.8047
            11  C1y C    20.3063  -30.3170
            12  C1x C    24.9121  -27.4558
            13  C8y C    20.3063  -25.1529
            14  C1x C    23.7258  -27.1069
            15  C8x C    22.5394  -25.1529
            16  N1y N    24.9124  -29.0608
            17  C2x C    21.4229  -31.0148
            18  O1a O    19.1200  -31.0148
            19  C8x C    21.4229  -24.4550
            20  O1a O    19.1898  -24.4550
            21  C1b C    26.3124  -29.0608
            22  C2b C    27.0096  -30.2684
            23  C2a C    28.4197  -30.2685
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 2
            13    7  14 1
            14    7  15 1
            15    8  16 1 #Up
            16    9  17 2
            17   11  18 1 #Down
            18   13  19 1
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 2
            25   16  21 1
            26   21  22 1
            27   22  23 2

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KEGG   DRUG: Nalorphine hydrochloride
Entry
D08248                      Drug                                   

Name
Nalorphine hydrochloride (USP);
Cloridrato de nalorfina (TN);
Nalline [veterinary] (TN)
Formula
C19H21NO3. HCl
Exact mass
347.1288
Mol weight
347.8359
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
ATC code: V03AB02
Chemical structure group: DG01151
Efficacy
Antidote (morphine), Opioid receptor agonist/antagonist
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB02 Nalorphine
      D08248  Nalorphine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08248  Nalorphine hydrochloride (USP)
    OPRK1
     D08248  Nalorphine hydrochloride (USP)
Other DBs
CAS: 57-29-4
PubChem: 96024936
ChEMBL: CHEMBL1908349
LigandBox: D08248
NIKKAJI: J231.290E
LinkDB
KCF data

ATOM        24
            1   C1z C    21.4229  -28.4328
            2   C8y C    21.4229  -27.1069
            3   C1y C    22.5394  -29.0608
            4   C1y C    20.3063  -29.0608
            5   C1x C    22.3999  -27.4558
            6   C8y C    20.3063  -26.4090
            7   C8y C    22.5394  -26.4090
            8   C1y C    23.7258  -28.4328
            9   C2x C    22.5394  -30.3868
            10  O2x O    19.2596  -27.8047
            11  C1y C    20.3063  -30.3170
            12  C1x C    24.9121  -27.4558
            13  C8y C    20.3063  -25.1529
            14  C1x C    23.7258  -27.1069
            15  C8x C    22.5394  -25.1529
            16  N1y N    24.9124  -29.0608
            17  C2x C    21.4229  -31.0148
            18  O1a O    19.1200  -31.0148
            19  C8x C    21.4229  -24.4550
            20  O1a O    19.1898  -24.4550
            21  C1b C    26.3124  -29.0608
            22  C2b C    27.0096  -30.2684
            23  C2a C    28.4197  -30.2685
            24  X   Cl   27.0057  -24.5248
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 2
            13    7  14 1
            14    7  15 1
            15    8  16 1 #Up
            16    9  17 2
            17   11  18 1 #Down
            18   13  19 1
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 2
            25   16  21 1
            26   21  22 1
            27   22  23 2

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