| Entry |
|
|---|
| Name |
Naloxone hydrochloride (JP17/USP);
Narcan (TN)
|
|---|
| Product |
|
|---|
| Generic |
NALOXONE HCI (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (Akorn), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (Dr. Reddy's Laboratories), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables and Vaccines), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (IJ Therapeutics), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HCL (Renaissance SSA), NALOXONE HYDROCHLORIDE (Sina Health), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Civica), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions) |
|---|
| Formula |
C19H21NO4. HCl
|
|---|
| Exact mass |
363.1237
|
|---|
| Mol weight |
363.8353
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Analgesic
DG01586 Opioid receptor antagonist
Other
DG01718 Drugs for addictive disorder
DG01717 Drugs for opioid dependence
|
|---|
| Remark |
| Therapeutic category: | 2219 |
| Product (DG01155): | D01340<JP/US> |
| Product (mixture): | D10250<US> |
|
|---|
| Efficacy |
Respiratory stimulant, Opioid receptor antagonist |
|---|
| Comment |
Normorphine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A06 DRUGS FOR CONSTIPATION
A06A DRUGS FOR CONSTIPATION
A06AH Peripheral opioid receptor antagonist
A06AH04 Naloxone
D01340 Naloxone hydrochloride (JP17/USP) <JP/US>
V VARIOUS
V03 ALL OTHER THERAPEUTIC PRODUCTS
V03A ALL OTHER THERAPEUTIC PRODUCTS
V03AB Antidotes
V03AB15 Naloxone
D01340 Naloxone hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
Anti-Addiction/Substance Abuse Treatment Agents
Opioid Reversal Agents
Naloxone
D01340 Naloxone hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
221 Respiratory stimulants
2219 Others
D01340 Naloxone hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D01340 Naloxone hydrochloride (JP17/USP) <JP/US>
OPRK1
D01340 Naloxone hydrochloride (JP17/USP) <JP/US>
OPRD1
D01340 Naloxone hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01340 Naloxone hydrochloride
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 25
1 X Cl 21.7908 -14.2119
2 C1z C 14.0948 -15.5899
3 C8y C 14.0948 -14.2668
4 C1z C 15.2786 -16.2861
5 C1y C 12.9806 -16.2166
6 C1x C 15.2786 -14.9632
7 C8y C 12.9806 -13.6401
8 C8y C 15.2786 -13.6401
9 C1y C 16.3927 -15.5899
10 C1x C 15.2786 -17.5396
11 O2x O 11.6576 -14.8934
12 C5x C 12.9806 -17.5396
13 C1x C 17.5068 -14.9632
14 C8y C 12.9806 -12.3171
15 C1x C 16.3927 -14.3364
16 C8x C 15.2786 -12.3171
17 N1y N 17.5068 -16.2861
18 C1x C 14.0948 -18.2359
19 O5x O 11.8665 -18.2359
20 C8x C 14.1644 -11.6904
21 O1a O 11.8665 -11.6904
22 O1a O 16.5319 -17.1914
23 C1b C 18.9047 -16.2861
24 C2b C 19.6072 -17.5026
25 C2a C 21.0000 -17.5025
BOND 28
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1 #Up
5 3 7 2
6 3 8 1
7 4 9 1
8 4 10 1
9 5 11 1 #Down
10 5 12 1
11 6 13 1
12 7 14 1
13 8 15 1
14 8 16 2
15 9 17 1 #Up
16 10 18 1
17 12 19 2
18 14 20 2
19 14 21 1
20 7 11 1
21 9 15 1
22 12 18 1
23 13 17 1
24 16 20 1
25 4 22 1 #Up
26 17 23 1
27 23 24 1
28 24 25 2
|
|---|
|
