KEGG   DRUG: Naloxone
Entry
D08249                      Drug                                   

Name
Naloxone (INN);
DBL Naloxone (TN)
Formula
C19H21NO4
Exact mass
327.1471
Mol weight
327.3743
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
Same as: C07252
ATC code: A06AH04 V03AB15
Chemical structure group: DG01155
Product (DG01155): D01340<JP/US> D11620<US>
Product (mixture): D10250<US>
Efficacy
Narcotic antagonist, Respiratory stimulant, Opioid receptor antagonist
Comment
Normorphine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonist
     A06AH04 Naloxone
      D08249  Naloxone (INN)
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D08249  Naloxone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08249  Naloxone (INN)
    OPRK1
     D08249  Naloxone (INN)
    OPRD1
     D08249  Naloxone (INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08249
Other DBs
CAS: 465-65-6
PubChem: 96024937
ChEBI: 7459
ChEMBL: CHEMBL80
DrugBank: DB01183
LigandBox: D08249
NIKKAJI: J5.894G
LinkDB
KCF data

ATOM        24
            1   C1z C    21.9100  -18.6200
            2   C8y C    21.9100  -17.2900
            3   C1z C    23.1000  -19.2500
            4   C1y C    20.7900  -19.1800
            5   C1x C    23.1000  -17.9900
            6   C8y C    20.7900  -16.6600
            7   C8y C    23.1000  -16.6600
            8   C1y C    24.2200  -18.6200
            9   C1x C    23.1000  -20.5100
            10  O2x O    19.4600  -17.9200
            11  C5x C    20.7900  -20.5100
            12  C1x C    25.3400  -17.9900
            13  C8y C    20.7900  -15.3300
            14  C1x C    24.2200  -17.3600
            15  C8x C    23.1000  -15.3300
            16  N1y N    25.3400  -19.2500
            17  C1x C    21.9100  -21.2100
            18  O5x O    19.6700  -21.2100
            19  C8x C    21.9800  -14.7000
            20  O1a O    19.6700  -14.7000
            21  O1a O    24.3600  -20.1600
            22  C1b C    26.7400  -19.2500
            23  C2b C    27.4400  -20.5100
            24  C2a C    28.8400  -20.5100
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25    3  21 1 #Up
            26   16  22 1
            27   22  23 1
            28   23  24 2

» Japanese version   » Back

KEGG   DRUG: Naloxone hydrochloride
Entry
D01340                      Drug                                   

Name
Naloxone hydrochloride (JP17/USP);
Evzio (TN);
Narcan (TN)
Product
  Generic
NALOXONE HCI (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (Akorn), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (Baxter Healthcare Corporation), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables and Vaccines), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (IJ Therapeutics), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (International Medication Systems), LIFEMS NALOXONE (Lifsa Drugs LLC), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (REMEDYREPACK), NALOXONE HYDROCHLORIDE (REMEDYREPACK), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Civica), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions)
Formula
C19H21NO4. HCl
Exact mass
363.1237
Mol weight
363.8353
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
Therapeutic category: 2219
ATC code: A06AH04 V03AB15
Chemical structure group: DG01155
Product (DG01155): D01340<JP/US> D11620<US>
Product (mixture): D10250<US>
Efficacy
Respiratory stimulant, Opioid receptor antagonist
Comment
Normorphine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonist
     A06AH04 Naloxone
      D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Reversal Agents
   Naloxone
    D01340  Naloxone hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   221  Respiratory stimulants
    2219  Others
     D01340  Naloxone hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
    OPRK1
     D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
    OPRD1
     D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01340  Naloxone hydrochloride
Other DBs
CAS: 357-08-4
PubChem: 7848403
ChEBI: 31892
ChEMBL: CHEMBL1718
DrugBank: DB01183
LigandBox: D01340
NIKKAJI: J219.954H
LinkDB
KCF data

ATOM        25
            1   X   Cl   21.7908  -14.2119
            2   C1z C    14.0948  -15.5899
            3   C8y C    14.0948  -14.2668
            4   C1z C    15.2786  -16.2861
            5   C1y C    12.9806  -16.2166
            6   C1x C    15.2786  -14.9632
            7   C8y C    12.9806  -13.6401
            8   C8y C    15.2786  -13.6401
            9   C1y C    16.3927  -15.5899
            10  C1x C    15.2786  -17.5396
            11  O2x O    11.6576  -14.8934
            12  C5x C    12.9806  -17.5396
            13  C1x C    17.5068  -14.9632
            14  C8y C    12.9806  -12.3171
            15  C1x C    16.3927  -14.3364
            16  C8x C    15.2786  -12.3171
            17  N1y N    17.5068  -16.2861
            18  C1x C    14.0948  -18.2359
            19  O5x O    11.8665  -18.2359
            20  C8x C    14.1644  -11.6904
            21  O1a O    11.8665  -11.6904
            22  O1a O    16.5319  -17.1914
            23  C1b C    18.9047  -16.2861
            24  C2b C    19.6072  -17.5026
            25  C2a C    21.0000  -17.5025
BOND        28
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     4  10 1
            9     5  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    7  14 1
            13    8  15 1
            14    8  16 2
            15    9  17 1 #Up
            16   10  18 1
            17   12  19 2
            18   14  20 2
            19   14  21 1
            20    7  11 1
            21    9  15 1
            22   12  18 1
            23   13  17 1
            24   16  20 1
            25    4  22 1 #Up
            26   17  23 1
            27   23  24 1
            28   24  25 2

» Japanese version   » Back

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