KEGG   DRUG: Amoxicillin hydrate, clarithromycin and lansoprazole
Entry
D08774            Mixture   Drug                                   
Name
Amoxicillin hydrate, clarithromycin and lansoprazole;
Lansap (TN);
Prevpac (TN)
Product
  Generic
LANSOPRAZOLE, AMOXICILLIN, CLARITHROMYCIN (Rising Pharma Holdings)
Component
Amoxicillin hydrate [DR:D00229], Clarithromycin [DR:D00276], Lansoprazole [DR:D00355]
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: A02BD07 J01RA01
Product: D08774<US>
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Lansoprazole is primarily metabolized by CYP2C19 and CYP3A4.
Clarithromycin is an inhibitor and a substrate of CYP3A4, and it is an inhibitor of P-gp.
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD07 Lansoprazole, amoxicillin and clarithromycin
      D08774  Amoxicillin hydrate, clarithromycin and lansoprazole <US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01R COMBINATIONS OF ANTIBACTERIALS
    J01RA Combinations of antibacterials
     J01RA01 Penicillins, combinations with other antibacterials
      D08774  Amoxicillin hydrate, clarithromycin and lansoprazole <US>
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D08774  Amoxicillin hydrate, clarithromycin and lansoprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D08774  Amoxicillin hydrate, clarithromycin and lansoprazole
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D08774  Amoxicillin hydrate, clarithromycin and lansoprazole
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   D08774  Amoxicillin hydrate, clarithromycin and lansoprazole
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D08774  Amoxicillin hydrate, clarithromycin and lansoprazole <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08774
 Drug transporters
  D08774
Other DBs
PubChem: 96025457
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system