KEGG   DRUG: SolanezumabHelp
Entry
D10058                      Drug                                   

Name
Solanezumab (USAN/INN);
Solanezumab (genetical recombination) (JAN)
Formula
C6396H9922N1712O1996S42
Exact mass
143993.5792
Mol weight
144082.2207
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS RYSMSWVRQA PGKGLELVAQ INSVGNSTYY
PDTVKGRFTI SRDNAKNTLY LQMNSLRAED TAVYYCASGD YWGQGTLVTV SSASTKGPSV
FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV
VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP
KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV
LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL
TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC
SVMHEALHNH YTQKSLSLSP G
(Light chain)
DVVMTQSPLS LPVTLGQPAS ISCRSSQSLI YSDGNAYLHW FLQKPGQSPR LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHVP WTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H139-H195, H215-L219, H221-H'221, H224-H'224, H256-H316, H362-H420, H'22-H'96, H'139-H'195, H'215-L'219, H'256-H'316, H'362-H'420, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Agents for Alzheimer-type dementia
Efficacy
Dementia therapeutic agent
Comment
Monoclonal antibody
Alzheimer's disease
Target
beta-amyloid
Structure map
map07056  Agents for Alzheimer-type dementia
Other DBs
CAS: 955085-14-0
PubChem: 135626778
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