KEGG   DRUG: Elvitegravir - cobicistat - emtricitabine - tenofovir alafenamide mixtHelp
Entry
D10755            Mixture   Drug                                   

Name
Elvitegravir - cobicistat - emtricitabine - tenofovir alafenamide mixt;
Genvoya (TN)
Product
Component
Elvitegravir [DR:D06677], Cobicistat [DR:D09881], Emtricitabine [DR:D01199], (Tenofovir alafenamide fumarate [DR:D10605] | Tenofovir alafenamide [DR:D10428])
Remark
Therapeutic category: 6250
ATC code: J05AR18
Product: D10755<JP/US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Elvitegravir and cobicistat are metabolized by CYP3A.
Cobicistat is also metabolized, to a minor extent, by CYP2D6.
Elvitegravir is a modest inducer of CYP2C9.
Cobicistat is an inhibitor of CYP3A and CYP2D6, and it is an inhibitor of the following transporters: P-gp, BCRP, OATP1B1 and OATP1B3. It is metabolized by OCT2.
Tenofovir alafenamide is a substrate of P-glycoprotein (P-gp) and CYP3A.
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR18 Emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat
      D10755  Elvitegravir - cobicistat - emtricitabine - tenofovir alafenamide mixt <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Integrase Inhibitors (INSTI)
   Elvitegravir/Cobicistat/Emtricitabine/Tenofovir alafenamide
    D10755  Elvitegravir - cobicistat - emtricitabine - tenofovir alafenamide mixt
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10755  Elvitegravir - cobicistat - emtricitabine - tenofovir alafenamide mixt
Antiinfectives [br08350.html]
 Antivirals
  D10755
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10755
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10755
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10755
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10755
BRITE hierarchy
Other DBs
PubChem: 273220351
ChEBI: 90922
LinkDB All DBs

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