KEGG   DRUG: Inebilizumab
Entry
D11757                      Drug                                   

Name
Inebilizumab (USAN/INN);
Inebilizumab-cdon;
Uplinza (TN)
Product
Formula
C6504H10080N1732O2044S44
Exact mass
146560.5771
Mol weight
146650.866
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SSWMNWVRQA PGKGLEWVGR IYPGDGDTNY
NVKFKGRFTI SRDDSKNSLY LQMNSLKTED TAVYYCARSG FITTVRDFDY WGQGTLVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKRVE PKSCDKTHTC PPCPAPELLG
GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
(Light chain)
EIVLTQSPDF QSVTPKEKVT ITCRASESVD TFGISFMNWF QQKPDQSPKL LIHEASNQGS
GVPSRFSGSG SGTDFTLTIN SLEAEDAATY YCQQSKEVPF TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H148-H204, H224-L224, H230-H'230, H265-H325, H371-H429, LH'22-H'96, H'148-H'204, H'224-L'218 H'148-H'204, G'265-H'325, H'371-H'429, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Remark
Product: D11757<US>
Efficacy
Antineoplastic, Anti-CD19 antibody
  Disease
Neuromyelitis optica spectrum disorder (AQP4 antibody positive) [DS:H01491]
Comment
Monoclonal antibody
Treatment of cancer, systemic sclerosis, and multiple sclerosis
Target
CD19 [HSA:930] [KO:K06465]
  Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04662  B cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD19
     D11757  Inebilizumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11757
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11757
Other DBs
CAS: 1299440-37-1
PubChem: 405226623
LinkDB

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