| Entry |
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| Name |
Adult T-cell leukemia |
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| Description |
Adult T-cell leukemia (ATL) is one of the most aggressive hematologic malignancies and is caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 Tax protein has been demonstrated to be the oncogenic protein of the virus. Tax may contribute to the process of carcinogenesis by a variety of mechanisms, including upregulating the expression of cellular genes involved in T cell growth and proliferation, including IL-2, IL-2R-alpha, and IL-15. However, ATL cells do not always need Tax expression in the later stage of leukemogenesis. Genetic and epigenetic changes should be implicated in such multistep leukemogenesis. Regarding genetic changes, mutation of p53, and deletion of p16 have been reported in ATL. Mutations of Fas gene are also reported in patients with ATL cells. However, such genetic changes were not frequently detected. In this regard, epigenetic change of p16/INK4A gene was more frequent in ATL cells, and accumulated according to the disease progression. This finding suggests that epigenetic change, including DNA methylation, plays an important role in the leukemogenesis of ATL.
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| Category |
Cancer
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| Brite |
Human diseases [BR:br08402]
Cancers
Cancers of haematopoietic and lymphoid tissues
H00009 Adult T-cell leukemia
Infectious diseases [BR:br08401]
Viral infections
Infections caused by ssRNA-RT viruses
H00009 Adult T-cell leukemia
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Neoplasms of haematopoietic or lymphoid tissues
Mature T-cell or NK-cell neoplasms
2A90 Mature T-cell lymphoma, specified types, nodal or systemic
H00009 Adult T-cell leukemia
Tumor markers [br08442.html]
H00009
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| Pathway |
| hsa05166 | Human T-cell leukemia virus 1 infection |
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| Network |
nt06114 PI3K signaling (viruses) nt06118 TGFB signaling (viruses) nt06119 JAK-STAT signaling (viruses) nt06120 Calcium signaling (viruses and bacteria) nt06123 TNF signaling (viruses and bacteria) nt06129 MHC presentation (viruses) nt06130 Cell cycle (viruses) nt06140 Transcription (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) |
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| Element |
| N00221 | HTLV-1 Tax to spindle assembly checkpoint signaling |
| N00222 | HTLV-1 Tax to spindle assembly checkpoint signaling |
| N00489 | HTLV-1 p30II to c-myc-mediated transcription |
| N00490 | HTLV-1 p12 to calcineurin signaling pathway |
| N00491 | HTLV-1 p12 to Jak-STAT signaling pathway |
| N00492 | HTLV-1 p12 to antigen processing and presentation by MHC class I molecules |
| N00494 | HTLV-1 Tax to p16-cell cycle G1/S |
| N00495 | HTLV-1 Tax to p15-cell cycle G1/S |
| N00497 | HTLV-1 Tax to p21-cell cycle G1/S |
| N00498 | HTLV-1 Tax to p21-cell cycle G1/S |
| N00500 | HTLV-1 Tax to p21-cell cycle G2/M |
| N00501 | HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway |
| N00502 | HTLV-1 Tax to PTEN-PIP3-AKT signaling pathway |
| N00503 | HTLV-1 Tax to TNF-JNK signaling pathway |
| N00504 | HTLV-1 Tax to NFKB signaling pathway |
| N00506 | HTLV-1 Tax to CD40-NFKB signaling pathway |
| N00507 | HTLV-1 Tax to TGF-beta signaling pathway |
| N00508 | HTLV-1 Tax to NFY-mediated transcription |
| N00509 | HTLV-1 Tax to SRF-mediated transcription |
| N00510 | HTLV-1 Tax to CREB-mediated transcription |
| N00511 | HTLV-1 Tax to E47-mediated transcription |
| N00512 | HTLV-1 Tax to c-myc-mediated transcription |
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| Gene |
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| Pathogen |
Human T-lymphotropic virus 1 [GN: T40003] |
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| Comment |
ICD-O: 9827/3, Tumor type: Adult T-cell leukaemia
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| Other DBs |
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| Reference |
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| Authors |
Matsuoka M |
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| Title |
Human T-cell leukemia virus type I and adult T-cell leukemia. |
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| Journal |
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| Reference |
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| Authors |
Yasunaga J, Matsuoka M |
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| Title |
Leukemogenesis of adult T-cell leukemia. |
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| Journal |
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| Reference |
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| Authors |
Maeda T, Yamada Y, Moriuchi R, Sugahara K, Tsuruda K, Joh T, Atogami S, Tsukasaki K, Tomonaga M, Kamihira S. |
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| Title |
Fas gene mutation in the progression of adult T cell leukemia. |
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| Journal |
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| Reference |
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| Authors |
Yasunaga J, Matsuoka M. |
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| Title |
Human T-cell leukemia virus type I induces adult T-cell leukemia: from clinical aspects to molecular mechanisms. |
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| Journal |
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| Reference |
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| Authors |
Jarrett RF. |
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| Title |
Viruses and lymphoma/leukaemia. |
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| Journal |
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| LinkDB |
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