Entry |
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Name |
Cervical cancer |
Description |
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
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Category |
Cancer
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Brite |
Human diseases [BR:br08402]
Cancers
Cancers of the breast and female genital organs
H00030 Cervical cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of female genital organs
2C77 Malignant neoplasms of cervix uteri
H00030 Cervical cancer
Cancer-associated carbohydrates [br08441.html]
H00030
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Pathway |
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Network |
nt06110 MAPK signaling (viruses and bacteria) nt06114 PI3K signaling (viruses) nt06116 NOTCH signaling (viruses) nt06121 TLR signaling (viruses and bacteria) nt06122 IFN signaling (viruses) nt06123 TNF signaling (viruses and bacteria) nt06129 MHC presentation (viruses) nt06130 Cell cycle (viruses) nt06131 Apoptosis (viruses and bacteria) nt06135 Cytoskeletal regulation (viruses and bacteria) nt06140 Transcription (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06166 Human papillomavirus (HPV) |
Element |
N00341 | HPV E6 to the Scribble/Dlg/Lgl polarity module |
N00343 | HPV E6 to MAGI-PTEN signaling pathway |
N00345 | HPV E6 to CRB3-Pals1-PATJ complex |
N00346 | HPV E6 to TLR-IRF3 signaling pathway |
N00348 | HPV E6 to p300-p21-Cell cycle G1/S |
N00349 | HPV E6 to p300-p21-Cell cycle G1/S |
N00350 | HPV E6 to extrinsic apoptotic pathway |
N00351 | HPV E6 to extrinsic apoptotic pathway |
N00352 | HPV E6 to extrinsic apoptotic pathway |
N00353 | HPV E6 to PTEN-PIP3-AKT signaling pathway |
N00354 | HPV E6 to PTEN-PIP3-AKT signaling pathway |
N00356 | HPV E7 to PP2A-AKT signaling patyway |
N00357 | HPV E6 to MTOR signaling pathway |
N00358 | HPV E6 to p21-cell cycle G1/S |
N00359 | HPV E7 to p27-cell cycle G1/S |
N00360 | HPV E7 to p27-cell cycle G1/S |
N00361 | HPV E7 to cell cycle G1/S |
N00362 | HPV E5 to p21-cell cycle G1/S |
N00364 | HPV E5 to antigen processing and presentation by MHC class I molecules |
N00365 | HPV E7 to cell cycle G1/S |
N00366 | HPV E5 to EGFR-PI3K signaling pathway |
N00367 | HPV E5 to EGFR-RAS-ERK signaling pathway |
N00368 | HPV E5 to PDGFR-PI3K signaling pathway |
N00369 | HPV E5 to PDGFR-RAS-ERK signaling pathway |
N00371 | HPV E7 to pyruvate generation |
N00372 | HPV E7 to p300-p21-Cell cycle G1/S |
N00373 | HPV E6 to NFX1-mediated transcription |
N00375 | HPV E7 to TNF-IRF1 signaling pathway |
N00376 | HPV E7 to TBP1-mediated transcription |
N00377 | HPV E6 to IFN signaling pathway |
N00378 | HPV E6 to IFN signaling pathway |
N00379 | HPV E7 to IFN signaling pathway |
N00380 | HPV E6 to Notch signaling pathway |
N00381 | HPV E6 to Notch signaling pathway |
N00382 | HPV E6 to Notch signaling pathway |
N00383 | HPV E6 to intrinsic apoptotic pathway |
N00384 | HPV E6 to intrinsic apoptotic pathway |
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Gene |
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Carcinogen |
Azathioprine [CPD: C06837]
Diethylstilboestrol [CPD: C07620]
Estrogens, nonsteroidal
Tobacco smoking and tobacco smoke
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Pathogen |
Human papillomavirus type 16 [GN: T40087] Human papillomavirus type 18 [GN: T40088] |
Drug |
Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR: D10192]
Topotecan hydrochloride [DR: D02168]
Bevacizumab [DR: D06409]
Pembrolizumab [DR: D10574] (PD-L1 expressed)
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Comment |
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma, not otherwise specified
ICD-O: 8140/3, Tumor type: Adenocarcinoma
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Other DBs |
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Reference |
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Authors |
Wolf JK, Ramirez PT. |
Title |
The molecular biology of cervical cancer. |
Journal |
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Reference |
|
Authors |
Lazo PA. |
Title |
The molecular genetics of cervical carcinoma. |
Journal |
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Reference |
|
Authors |
Patel P, Moazzam N, Potti A, Mehdi SA. |
Title |
Azathioprine induced hodgkin lymphoma: a case report and review of literature. |
Journal |
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Reference |
|
Authors |
Schrager S, Potter BE. |
Title |
Diethylstilbestrol exposure. |
Journal |
Am Fam Physician 69:2395-400 (2004) |
Reference |
|
Authors |
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN. |
Title |
Cancer risk in women prenatally exposed to diethylstilbestrol. |
Journal |
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Reference |
|
Authors |
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK. |
Title |
Human papillomavirus infections: epidemiology, pathogenesis, and therapy. |
Journal |
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Reference |
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Authors |
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. |
Title |
Environmental and chemical carcinogenesis. |
Journal |
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Reference |
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Authors |
Sasco AJ, Secretan MB, Straif K. |
Title |
Tobacco smoking and cancer: a brief review of recent epidemiological evidence. |
Journal |
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Reference |
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Authors |
Baldwin P, Laskey R, Coleman N. |
Title |
Translational approaches to improving cervical screening. |
Journal |
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Reference |
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Authors |
Garland SM. |
Title |
Can we really beat cervical cancer? |
Journal |
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Reference |
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Authors |
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR. |
Title |
Serum tumor markers in the management of ovarian, endometrial and cervical cancer. |
Journal |
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LinkDB |
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