KEGG   DISEASE: Enterohemorrhagic Escherichia coli (EHEC) infection
Entry
H00277                      Disease                                

Name
Enterohemorrhagic Escherichia coli (EHEC) infection
Description
Enterohemorrhagic Escherichia coli (EHEC) infection is typically contracted through consumption of contaminated food or contact with contaminated water, animal feces or infected animals. EHEC is also referred to as verocytotoxin producing E. coli (VTEC) or Shiga toxin producing E. coli (STEC). The serotype O157:H7 is first associated with human disease after a multistate outbreak in the United States in 1982 involving contaminated hamburgers.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A03  Intestinal infections due to Escherichia coli
     H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
Pathway
hsa05130  Pathogenic Escherichia coli infection
Network
nt06121  TLR signaling (viruses and bacteria)
nt06123  TNF signaling (viruses and bacteria)
nt06131  Apoptosis (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses)
nt06139  NLR signaling (viruses and bacteria)
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
N00927  Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
N00928  Escherichia NleB to TNF-NFKB signaling pathway
N00929  Escherichia NleC to TNF-NFKB signaling pathway
N00930  Escherichia NleD to TNF-JNK signaling pathway
N00931  Escherichia NleD to TNF-p38 signaling pathway
N00932  Escherichia NleH1 to TNF-NFKB signaling pathway
N00933  Escherichia NleA to NLRP3 inflammasome signaling pathway
N00935  Escherichia NleF to non-canonical inflammasome signaling pathway
N00936  Escherichia NleB1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00937  Escherichia NleF to extrinsic apoptotic pathway
N00938  Escherichia NleH to intrinsic apoptotic pathway
N00939  Escherichia EspF to intrinsic apoptotic pathway
N01084  Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway
N01085  Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01087  Escherichia EspW to RAC signaling pathway
N01088  Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway
N01089  Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
N01091  Escherichia EspJ to IGG-FCGR-RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01093  Escherichia EspJ/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01095  Escherichia Map to LPA-GNA12/13-RhoA signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01288  Escherichia EspF to Tight junction-Actin signaling pathway
Pathogen
Escherichia coli O157:H7 [GN:ece ecs ecf etw elx]
Escherichia coli O26:H11 [GN:eoj]
Escherichia coli O111:H- [GN:eoi]
Escherichia coli O103:H2 [GN:eoh]
Escherichia coli O104:H4 [GN:esl eso esm]
Escherichia coli O145:H28 [GN:ecoo ecoh]
  Module
M00542  EHEC/EPEC pathogenicity signature, T3SS and effectors
M00363  EHEC pathogenicity signature, Shiga toxin
Other DBs
ICD-11: 1A03.3
ICD-10: A04.3
MeSH: D004927
Reference
  Authors
Baker DR, Moxley RA, Steele MB, Lejeune JT, Christopher-Hennings J, Chen DG, Hardwidge PR, Francis DH
  Title
Differences in virulence among Escherichia coli O157:H7 strains isolated from humans during disease outbreaks and from healthy cattle.
  Journal
Appl Environ Microbiol 73:7338-46 (2007)
DOI:10.1128/AEM.00755-07
Reference
  Authors
Ahmed SA, Awosika J, Baldwin C, Bishop-Lilly KA, Biswas B, Broomall S, Chain PS, Chertkov O, Chokoshvili O, Coyne S, Davenport K, Detter JC, Dorman W, Erkkila TH, Folster JP, Frey KG, George M, Gleasner C, Henry M, Hill KK, Hubbard K, Insalaco J, Johnson S, Kitzmiller A, Krepps M, Lo CC, Luu T, McNew LA, Minogue T, Munk CA, Osborne B, Patel M, Reitenga KG, Rosenzweig CN, Shea A, Shen X, Strockbine N, Tarr C, Teshima H, van Gieson E, Verratti K, Wolcott M, Xie G, Sozhamannan S, Gibbons HS
  Title
Genomic comparison of Escherichia coli O104:H4 isolates from 2009 and 2011 reveals plasmid, and prophage heterogeneity, including shiga toxin encoding phage stx2.
  Journal
PLoS One 7:e48228 (2012)
DOI:10.1371/journal.pone.0048228
LinkDB

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KEGG   DISEASE: Enteropathogenic Escherichia coli (EPEC) infection
Entry
H00278                      Disease                                

Name
Enteropathogenic Escherichia coli (EPEC) infection
Description
Enteropathogenic Escherichia coli (EPEC) was the first pathotype of E. coli identified in the 1940s, and remains a common cause of infantile diarrhea in developing countries. EPEC and EHEC [DS:H00277] strains are characterized by the type III secretion system and its cognate effectors encoded in the locus of enterocyte effacement (LEE), but EPEC does not release diffusible toxins.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00278  Enteropathogenic Escherichia coli (EPEC) infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A03  Intestinal infections due to Escherichia coli
     H00278  Enteropathogenic Escherichia coli (EPEC) infection
Pathway
hsa05130  Pathogenic Escherichia coli infection
Network
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
N00927  Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
N00928  Escherichia NleB to TNF-NFKB signaling pathway
N00929  Escherichia NleC to TNF-NFKB signaling pathway
N00930  Escherichia NleD to TNF-JNK signaling pathway
N00931  Escherichia NleD to TNF-p38 signaling pathway
N00932  Escherichia NleH1 to TNF-NFKB signaling pathway
N00933  Escherichia NleA to NLRP3 inflammasome signaling pathway
N00935  Escherichia NleF to non-canonical inflammasome signaling pathway
N00936  Escherichia NleB1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00937  Escherichia NleF to extrinsic apoptotic pathway
N00938  Escherichia NleH to intrinsic apoptotic pathway
N00939  Escherichia EspF to intrinsic apoptotic pathway
N01084  Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway
N01085  Escherichia EspG to ARNO-ARF-ACTB/G signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01087  Escherichia EspW to RAC signaling pathway
N01088  Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway
N01089  Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
N01091  Escherichia EspJ to IGG-FCGR-RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01093  Escherichia EspJ/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01095  Escherichia Map to LPA-GNA12/13-RhoA signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01288  Escherichia EspF to Tight junction-Actin signaling pathway
Pathogen
Escherichia coli O127:H6 [GN:ecg]
Escherichia coli O55:H7 [GN:eok elr]
  Module
M00542  EHEC/EPEC pathogenicity signature, T3SS and effectors
Other DBs
ICD-11: 1A03.0
ICD-10: A04.0
MeSH: D004927
Reference
  Authors
Ochoa TJ, Barletta F, Contreras C, Mercado E
  Title
New insights into the epidemiology of enteropathogenic Escherichia coli infection.
  Journal
Trans R Soc Trop Med Hyg 102:852-6 (2008)
DOI:10.1016/j.trstmh.2008.03.017
LinkDB

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KEGG   DISEASE: Shigellosis
Entry
H00299                      Disease                                

Name
Shigellosis;
Bacillary dysentery
Description
Shigellosis (bacillary dysentery) is a foodborne enterobacterial infection caused by Shigella species. There are four subgroups of Shigella: S. dysenteriae, S. flexneri, S. boydii, and S. sonnei. Of these, S. flexneri is the most frequently observed worldwide, and S. dysenteriae causes severe disease with the highest fatality rate. Transmission usually occurs via contaminated food and water or through person-to-person contact.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00299  Shigellosis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A02  Intestinal infections due to Shigella
     H00299  Shigellosis
Pathway
hsa05131  Shigellosis
Network
nt06121  TLR signaling (viruses and bacteria)
nt06123  TNF signaling (viruses and bacteria)
nt06128  Autophagy (viruses and bacteria)
nt06131  Apoptosis (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses)
nt06139  NLR signaling (viruses and bacteria)
  Element
N00927  Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
N00941  Shigella IpaH9.8 to NOD-NFKB signaling pathway
N00942  Shigella OspG to TNF-NFKB signaling pathway
N00943  Shigella IpaH4.5 to TNF-NFKB signaling pathway
N00944  Shigella OspI to TNF-NFKB signaling pathway
N00945  Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway
N00946  Shigella IpaJ to cGAS-STING signaling pathway
N00947  Shigella Ipa4.5 to cGAS-STING signaling pathway
N00948  Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949  Shigella IpaB to NLRC4 Inflammasome signaling pathway
N00950  Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways
N00952  Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01069  Shigella IpgB1 to ITGA/B-FAK-RAC signaling pathway
N01071  Shigella IpgB1 to ITGA/B-FAK-CDC42 signaling pathway
N01073  Shigella IpgB2 to ITGA/B-RhoGEF-RhoA signaling pathway
N01074  Shigella IpaA to ITGA/B-RhoGEF-RhoA signaling pathway
N01075  Shigella IcsB to ITGA/B-RhoGEF-RhoA signaling pathway
N01076  Shigella IcsB to ITGA/B-FAK-CDC42 signaling pathway
N01077  Shigella IcsB to ITGA/B-FAK-RAC signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01081  Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01082  Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01083  Shigella OspE to ITGA/B-TALIN/VINCULIN signaling pathway
N01283  Shigella OspF to TLR2/4-MAPK signaling pathway
N01284  Shigella IcsP to Autophagy-vesicle elongation
Pathogen
Shigella flexneri [GN:sfl sfx sfv sfe sft]
Shigella sonnei [GN:ssn]
Shigella boydii [GN:sbo sbc]
Shigella dysenteriae [GN:sdy sdz]
shiga toxin [KO:K11006 K11007]
enterotoxin ShET-1 [KO:K11011 K11012]
Drug
Co-Trimoxazole [DR:D00285]
Other DBs
ICD-11: 1A02
ICD-10: A03
MeSH: D004405
MedlinePlus: 000295
Reference
  Authors
Kweon MN
  Title
Shigellosis: the current status of vaccine development.
  Journal
Curr Opin Infect Dis 21:313-8 (2008)
DOI:10.1097/QCO.0b013e3282f88b92
Reference
  Authors
Warren BR, Parish ME, Schneider KR
  Title
Shigella as a foodborne pathogen and current methods for detection in food.
  Journal
Crit Rev Food Sci Nutr 46:551-67 (2006)
DOI:10.1080/10408390500295458
Reference
  Authors
Niyogi SK
  Title
Shigellosis.
  Journal
J Microbiol 43:133-43 (2005)
LinkDB

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