KEGG   DISEASE: Plague
Entry
H00297                      Disease                                

Name
Plague
Description
Plague is a deadly infectious disease caused by Yersinia pestis. The pathogen has rodent reservoirs and is transmitted to humans usually by fleas as vectors. There are three major manifestations: bubonic, septicemic, and pneumonic plagues. Severe epidemics in the past include the Plague of Justinian in the sixth century, the Black Death in the fourteenth century, and the Third Pandemic that began in Central Asia in the nineteenth century. The genome sequences have been determined for the strains responsible for these epidemics.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00297  Plague
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Certain zoonotic bacterial diseases
   1B93  Plague
    H00297  Plague
Network
nt06120  Calcium signaling (viruses and bacteria)
nt06121  TLR signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06139  NLR signaling (viruses and bacteria)
  Element
N00859  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00860  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00861  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00862  Yersinia YopP/J to TLR2/4-MAPK signaling pathway
N00863  Yersinia YopM to NLRP3 Inflammasome signaling pathway
N00864  Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865  Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866  Yersinia YopM to Pyrin Inflammasome signaling pathway
N01098  Yersinia YopT to ITGA/B-RhoGEF-RhoA signaling pathway
N01099  Yersinia YopE to RhoA signaling pathway
N01100  Yersinia YopE to ITGA/B-RHOG-RAC signaling pathway
N01101  Yersinia YopT to ITGA/B-RHOG-RAC signaling pathway
N01102  Yersinia YopE to ITGA/B-RHOG-RAC signaling pathway
N01103  Yersinia YpkA to IGG-FCGR-RAC signaling pathway
N01105  Yersinia YpkA to LPA-GNAQ-RhoA signaling pathway
N01107  Yersinia YopH to TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
N01109  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
N01110  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
N01111  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
Pathogen
Yersinia pestis CO92 (biovar Orientalis) [GN:ype] (Third Pandemic)
Yersinia pestis KIM (biovar Mediaevalis) [GN:ypk] (Black Death)
Yersinia pestis Antiqua,Nepal516 (biovar Antiqua) [GN:ypa ypn] (Plague of Justinian)
Yersinia pestis Pestoides F [GN:ypp]
Yersinia pestis Angola [GN:ypg]
Yersinia pestis D106004 [GN:ypd]
Yersinia pestis D182038 [GN:ypx]
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Streptomycin sulfate [DR:D01350]
Demeclocycline hydrochloride [DR:D00290]
Ciprofloxacin [DR:D00186]
Ciprofloxacin hydrochloride [DR:D02216]
Levofloxacin [DR:D00588]
Moxifloxacin hydrochloride [DR:D00874]
Comment
Vector: Xenopsylla cheopis (rat flea)
murine toxin [KO:K11009]
Other DBs
ICD-11: 1B93
ICD-10: A20
MeSH: D010930
MedlinePlus: 000596
LinkDB

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KEGG   DISEASE: Yersiniosis
Entry
H00298                      Disease                                

Name
Yersiniosis
Description
Yersiniosis (non-plague) is an infectious disease caused by two species, Yersinia enterocolitica and Y. pseudotuberculosis, which is zoonotic, capable of being transmitted from infected animals to man. Routes of transmission include fecal-oral spread via ingestion of contaminated food as the most common route and consumption of contaminated water supplies. Yersiniosis occurs more commonly in regions with temperate rather than tropical or subtropical climates.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00298  Yersiniosis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A05  Intestinal infections due to Yersinia enterocolitica
     H00298  Yersiniosis
  Certain zoonotic bacterial diseases
   1B9A  Extraintestinal yersiniosis
    H00298  Yersiniosis
Pathway
hsa05135 Yersinia infection   
Network
  Element
N00859  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00860  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00861  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00862  Yersinia YopP/J to TLR2/4-MAPK signaling pathway
N00863  Yersinia YopM to NLRP3 Inflammasome signaling pathway
N00864  Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865  Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866  Yersinia YopM to Pyrin Inflammasome signaling pathway
N01098  Yersinia YopT to ITGA/B-RhoGEF-RhoA signaling pathway
N01099  Yersinia YopE to RhoA signaling pathway
N01100  Yersinia YopE to ITGA/B-RHOG-RAC signaling pathway
N01101  Yersinia YopT to ITGA/B-RHOG-RAC signaling pathway
N01102  Yersinia YopE to ITGA/B-RHOG-RAC signaling pathway
N01103  Yersinia YpkA to IGG-FCGR-RAC signaling pathway
N01105  Yersinia YpkA to LPA-GNAQ-RhoA signaling pathway
N01107  Yersinia YopH to TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
N01109  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
N01110  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
N01111  Yersinia YopH to ITGA/B-FAK-RAC signaling pathway
Pathogen
Yersinia pseudotuberculosis [GN:yps ypi ypq]
Yersinia enterocolitica [GN:yen yep yey yef]
superantigen [KO:K11010]
Other DBs
ICD-11: 1A05 1B9A
ICD-10: A04.6 A28.2
MeSH: D015009
Reference
  Authors
Smego RA, Frean J, Koornhof HJ
  Title
Yersiniosis I: microbiological and clinicoepidemiological aspects of plague and non-plague Yersinia infections.
  Journal
Eur J Clin Microbiol Infect Dis 18:1-15 (1999)
DOI:10.1007/s100960050219
Reference
  Authors
Pujol C, Bliska JB
  Title
Turning Yersinia pathogenesis outside in: subversion of macrophage function by intracellular yersiniae.
  Journal
Clin Immunol 114:216-26 (2005)
DOI:10.1016/j.clim.2004.07.013
LinkDB

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