KEGG   DISEASE: Myocardial infarctionHelp
Entry
H01730                      Disease                                

Name
Myocardial infarction
Description
Myocardial infarction (MI) or acute myocardial infarction (AMI) is a term for an event of heart attack. It is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart and injuring heart muscles because of lack of oxygen supply. The symptoms of MI include chest pain, which travels from left arm to neck, shortness of breath, nausea, epigastric discomfort, syncope, diaphoresis, and other factors. The diagnosis of MI is dependent on the sensitivity and specificity of the clinical criteria, electrocardiographic (ECG) findings, imaging studies and biomarkers used to detect death of cardiomyocytes. The treatment of MI includes, aspirin tablets, and to dissolve arterial blockage injection of thrombolytic or clot dissolving drugs such as tissue plasminogen activator, streptokinase or urokinase in blood within 3 h of the onset of a heart attack. Nitroglycerin and antihypertensive drugs such as beta-blockers and ACE inhibitors may also be used to lower blood pressure and to improve the oxygen demand of heart.
Category
Cardiovascular disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Cardiac diseases
   H01730  Myocardial infarction
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Ischaemic heart diseases
   Acute ischaemic heart disease
    BA41  Acute myocardial infarction
     H01730  Myocardial infarction
BRITE hierarchy
Env factor
Old age
Tobacco smoking
High blood pressure
High levels of LDL
High cholesterol and fat
Diabetes
Obesity
Chronic kidney disease
Alcohol
Cocaine
Amphetamines
Drug
Aspirin [DR:D00109]
Prasugrel hydrochloride [DR:D05597]
Cangrelor [DR:D03359]
Vorapaxar sulfate [DR:D09766]
Reteplase [DR:D05721]
Norepinephrine bitartrate [DR:D05206]
Dopamine hydrochloride [DR:D00633]
Nitroglycerin [DR:D00515]
Niacin [DR:D00049]
Propranolol hydrochloride [DR:D00483]
Metoprolol tartrate [DR:D00601]
Atenolol [DR:D00235]
Lovastatin [DR:D00359]
Other DBs
ICD-11: BA41
ICD-10: I21
MeSH: D009203
Reference
PMID:25638347 (definition, env_factor, drug)
  Authors
Lu L, Liu M, Sun R, Zheng Y, Zhang P
  Title
Myocardial Infarction: Symptoms and Treatments.
  Journal
Cell Biochem Biophys 72:865-7 (2015)
DOI:10.1007/s12013-015-0553-4
Reference
PMID:22922597 (description, marker)
  Authors
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD
  Title
Third universal definition of myocardial infarction.
  Journal
Nat Rev Cardiol 9:620-33 (2012)
DOI:10.1038/nrcardio.2012.122
Reference
PMID:26426469 (description, drug)
  Authors
Frangogiannis NG
  Title
Pathophysiology of Myocardial Infarction.
  Journal
Compr Physiol 5:1841-75 (2015)
DOI:10.1002/cphy.c150006
LinkDB All DBs

» Japanese version

DBGET integrated database retrieval system