KEGG   ORTHOLOGY: K00021
Entry
K00021                      KO                                     

Name
HMGCR
Definition
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04152  AMPK signaling pathway
ko04976  Bile secretion
Module
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
Other DBs
RN: R02082
COG: COG1257
GO: 0004420
Genes
HSA: 3156(HMGCR)
PTR: 471516(HMGCR)
PPS: 100990336(HMGCR)
GGO: 101136625(HMGCR)
PON: 100173499(HMGCR)
NLE: 100597442(HMGCR)
MCC: 705479(HMGCR)
MCF: 101926249(HMGCR)
CSAB: 103223243(HMGCR)
RRO: 104653755(HMGCR) 115895907 115896021 115896068
RBB: 108513080(HMGCR)
CJC: 100403990(HMGCR)
SBQ: 101033204(HMGCR)
MMU: 15357(Hmgcr)
MCAL: 110307857(Hmgcr)
MPAH: 110328787(Hmgcr)
RNO: 25675(Hmgcr)
CGE: 100756363(Hmgcr)
NGI: 103731354(Hmgcr)
HGL: 101717005(Hmgcr)
CCAN: 109700493(Hmgcr)
OCU: 100357791(HMGCR)
TUP: 102480274(HMGCR)
CFA: 479182(HMGCR)
VVP: 112919751(HMGCR)
AML: 100464316(HMGCR)
UMR: 103663564(HMGCR)
UAH: 113255200(HMGCR)
ORO: 101368294(HMGCR)
FCA: 101098922(HMGCR)
PTG: 102963640(HMGCR)
PPAD: 109274990(HMGCR)
AJU: 106974837(HMGCR)
BTA: 407159(HMGCR)
BOM: 102270355(HMGCR)
BIU: 109564640(HMGCR)
BBUB: 102394647(HMGCR)
CHX: 102169762(HMGCR)
OAS: 101108919(HMGCR)
SSC: 100144446(HMGCR)
CFR: 102507285(HMGCR)
CDK: 105084800(HMGCR)
LVE: 103081068(HMGCR)
OOR: 101275846(HMGCR)
DLE: 111185263(HMGCR)
PCAD: 102983040(HMGCR)
ECB: 100065577(HMGCR)
EPZ: 103555449(HMGCR)
EAI: 106824005(HMGCR)
MYB: 102262745(HMGCR)
MYD: 102767367(HMGCR)
MNA: 107531218(HMGCR)
HAI: 109381933(HMGCR)
DRO: 112307523(HMGCR)
PALE: 102890076(HMGCR)
RAY: 107506449(HMGCR)
MJV: 108408321(HMGCR)
LAV: 100661990(HMGCR)
TMU: 101360660
MDO: 100014439(HMGCR)
SHR: 100922433(HMGCR)
PCW: 110216572(HMGCR)
OAA: 100086613(HMGCR)
GGA: 395145(HMGCR)
MGP: 104915886(HMGCR)
CJO: 107306044(HMGCR)
NMEL: 110389857(HMGCR)
APLA: 101805369(HMGCR)
ACYG: 106042919(HMGCR)
TGU: 100228972(HMGCR)
LSR: 110471283(HMGCR)
SCAN: 103819488(HMGCR)
GFR: 102039836(HMGCR)
FAB: 101812070(HMGCR)
PHI: 102101959(HMGCR)
PMAJ: 107215886(HMGCR)
CCAE: 111940640(HMGCR)
CCW: 104685133(HMGCR)
ETL: 114057167(HMGCR)
FPG: 101915600(HMGCR)
FCH: 102052105(HMGCR)
CLV: 102088196(HMGCR)
EGZ: 104124861(HMGCR)
NNI: 104013038(HMGCR) 104017611
ACUN: 113490251(HMGCR)
PADL: 103919697(HMGCR)
AAM: 106489268
ASN: 102386377(HMGCR)
AMJ: 102571444(HMGCR)
PSS: 102459565(HMGCR)
CMY: 102947767(HMGCR)
CPIC: 101931267(HMGCR)
ACS: 100555648(hmgcr)
PVT: 110084573
PBI: 103059006(HMGCR)
PMUR: 107291177(HMGCR)
TSR: 106550050(HMGCR)
PMUA: 114606284(HMGCR)
GJA: 107118163(HMGCR)
XLA: 108707262(hmgcr.S) 397750(hmgcr.L)
XTR: 100380121(hmgcr)
NPR: 108796370(HMGCR)
DRE: 541479(hmgcrb) 559054(hmgcra)
IPU: 108255489(hmgcr) 108278928(HMGCR)
PHYP: 113535726 113536911(hmgcr)
EEE: 113573726 113574964(hmgcr)
TRU: 101066905(hmgcr) 101078757
LCO: 104926606 104937871(hmgcr)
NCC: 104951831 104964565(hmgcr)
XMA: 102229336 102237239(hmgcr)
XCO: 114149006 114155192(hmgcr)
PRET: 103470679(hmgcr) 103473284
CVG: 107090374 107093682(hmgcr)
CSEM: 103389902 103397369(hmgcr)
POV: 109626244 109640161(hmgcr)
LCF: 108873800 108878542(hmgcr)
HCQ: 109510552(hmgcr) 109525561
BPEC: 110157405 110172435(hmgcr)
SASA: 100380797(hmdh) 106570829(hmgcr)
OTW: 112220299
ELS: 105009321(hmgcr) 105015131
SFM: 108925108(hmgcr)
PKI: 111849962(hmgcr)
LCM: 102361998(HMGCR)
CMK: 103186373(hmgcr)
RTP: 109936281
BFO: 118410303
CIN: 100187175
SPU: 373355(HMGCR)
APLC: 110986789
SKO: 100369866
DME: Dmel_CG10367(Hmgcr)
DER: 6554339
DSE: 6607617
DSI: Dsimw501_GD21034(Dsim_GD21034)
DAN: 6499055
DSR: 110185563
DPE: 6587844
DMN: 108154668
DWI: 6649674
DAZ: 108621175
DNV: 108658955
DVI: 6630786
MDE: 101892909
LCQ: 111690994
AAG: 5571790
AME: 550724
BIM: 100746066
BTER: 100651787
CCAL: 108629833
OBB: 114875877
MPHA: 105831385
AEC: 105152804
ACEP: 105625102
PBAR: 105429601
HST: 105189357
DQU: 106746505
CFO: 105256970
LHU: 105667949
PGC: 109859982
OBO: 105283012
PCF: 106788979
NVI: 100117068
CSOL: 105363952
MDL: 103572658
BMOR: 100101204(Hmg-r)
BMAN: 114252510
PMAC: 106715604
PRAP: 110997222
HAW: 110382245
PXY: 105398578
DNX: 107170987
AGS: 114121337
RMD: 113557321
ZNE: 110835092
DPX: DAPPUDRAFT_346929(Hmgcr)
PVM: 113803763
TUT: 107360294
DPTE: 113798075
CSCU: 111640814
PTEP: 107444292
CEL: CELE_F08F8.2(hmgr-1)
CBR: CBG15296
BMY: Bm1_54020
TSP: Tsp_10921
PCAN: 112553957
CRG: 105320820
MYI: 110454220
OBI: 106880618
LAK: 106162017
SHX: MS3_08471
NVE: 5508715
EPA: 110243168
ADF: 107344111
AMIL: 114954020
PDAM: 113672697
SPIS: 111330985
DGT: 114522592
HMG: 100215451
AQU: 100635846
ATH: AT1G76490(HMG1) AT2G17370(HMG2)
LJA: Lj0g3v0018799.1(Lj0g3v0018799.1) Lj0g3v0268939.1(Lj0g3v0268939.1) Lj2g3v1574250.1(Lj2g3v1574250.1) Lj2g3v2948500.1(Lj2g3v2948500.1)
BVG: 104904096
DOSA: Os02t0713900-01(Os02g0713900) Os08t0512700-01(Os08g0512700) Os09t0492700-01(Os09g0492700)
ATS: 109746630(LOC109746630) 109752372(LOC109752372) 109782286(LOC109782286)
ATR: 18439724
SCE: YLR450W(HMG2) YML075C(HMG1)
ERC: Ecym_1136
KMX: KLMA_40445(HMG1)
NCS: NCAS_0A06180(NCAS0A06180)
NDI: NDAI_0D03170(NDAI0D03170)
TPF: TPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBL: TBLA_0E04740(TBLA0E04740)
TDL: TDEL_0D00740(TDEL0D00740)
KAF: KAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
PIC: PICST_72872(HMG1)
CAL: CAALFM_C103780CA(HMG1)
SLB: AWJ20_1837(HMG1)
NCR: NCU00712
NTE: NEUTE1DRAFT89746(NEUTE1DRAFT_89746)
MGR: MGG_08975
SSCK: SPSK_01389
FPU: FPSE_03466(HMR1)
NHE: NECHADRAFT_105420(NhHMR1)
MAW: MAC_02791
MAJ: MAA_05256
CMT: CCM_04994
MBE: MBM_03374
ANG: ANI_1_1022064(An07g08280) ANI_1_1548184(An04g00610)
ABE: ARB_00275
TVE: TRV_00650
PTE: PTT_07524
ZTR: MYCGRDRAFT_64888(HMG1)
SPO: SPCC162.09c(hmg1)
CNE: CNF04830
CNB: CNBF0070
TASA: A1Q1_01564
ABP: AGABI1DRAFT64187(AGABI1DRAFT_64187)
ABV: AGABI2DRAFT208992(AGABI2DRAFT_208992)
MGL: MGL_3624
MRT: MRET_0384
DDI: DDB_G0269142(hmgA) DDB_G0276615(hmgB)
DFA: DFA_02965(hmgB) DFA_07220
SPAR: SPRG_01272
LMA: LMJF_30_3190(HMGR)
LIF: LINJ_30_3230(HMGR)
LPAN: LPMP_303150(HMGR)
PLU: plu4507
VCH: VCA0723
VCS: MS6_A0769
VCE: Vch1786_II0408(hmgA)
VCI: O3Y_16913
VCR: VC395_A0589(hmgA)
VCM: VCM66_A0681(hmgA)
VVU: VV2_0117
VVY: VVA0625
VPA: VPA0968
VAG: N646_4347
VSP: VS_II0457
VAN: VAA_01552
VAU: VANGNB10_cII0695(hmgA)
VTA: B0124(hmgA)
VFI: VF_A0841
PSIL: PMA3_24025
PAT: Patl_0427
GNI: GNIT_1294(hmg1)
MVS: MVIS_1670(hmgA)
SAGA: M5M_16240
CBD: CBUD_0151 CBUD_0622(hmgA)
CBG: CbuG_0298 CbuG_1393(hmgA)
CBC: CbuK_0218 CbuK_1440(hmgA)
CEY: CleRT_04160(hmgA)
TCX: Tcr_1717
HMAR: HVMH_0539
DNO: DNO_0797
SVA: SVA_3750
CVI: CV_1806
BOK: DM82_1348
BOC: BG90_3346
LAA: WSI_04450
LSO: CKC_03800
LAR: lam_722(hMG1)
MALU: KU6B_29570
GAK: X907_0130
SAY: TPY_0167
MUL: MUL_3522
MMI: MMAR_3214
CKP: ckrop_0031(mvaA)
CVA: CVAR_1983(mvaA)
CTER: A606_07960
COA: DR71_1489
NFA: NFA_22110
SDV: BN159_7954(hmgA3)
STRE: GZL_00237
SFK: KY5_0603c
IDO: I598_0505
BSD: BLASA_0285(hmgA)
SEN: SACE_5541
SACG: FDZ84_37460(panC)
GBA: J421_4295
SRU: SRU_2422
SRM: SRM_02640(hmgA)
SGN: SGRA_2249
FAE: FAES_4555(hmgA)
HSW: Hsw_4017
FLM: MY04_1691
CPRV: CYPRO_0371
MJA: MJ_0705
MMP: MMP0087(hmgA)
MMD: GYY_00445
MMAK: MMKA1_00920(hmgA)
MMAO: MMOS7_01170(hmgA)
MMAD: MMJJ_10070
MAE: Maeo_0718
MVO: Mvol_1440
METF: CFE53_04475(hmgA)
MTH: MTH_562
MMG: MTBMA_c09500(hmgA)
METC: MTCT_0489
MWO: MWSIV6_0926(hmgA)
METE: tca_00533
METK: FVF72_08715(hmgA)
MTHM: FZP57_04445(hmgA)
MST: Msp_0584(hmgA)
MRU: mru_1092(hmgA)
MSI: Msm_0227
MEB: Abm4_0894(hmgA)
MMIL: sm9_0824(hmgA)
MEYE: TL18_06175
MOL: YLM1_0775
METH: MBMB1_1357(hmgA)
MFC: BRM9_0582(hmgA)
MFI: DSM1535_0563(hmgA)
MCUB: MCBB_1594(hmgA)
METT: CIT01_10430(hmgA)
METO: CIT02_11195(hmgA)
MFV: Mfer_0012
MKA: MK0355(hmg1)
MEAR: Mpt1_c04890(hmgA)
MARC: AR505_0768
PFU: PF1848
PFI: PFC_09350
PHO: PH1805(PH1805)
PAB: PAB2106
PYN: PNA2_0404
PYS: Py04_1729
TKO: TK0914
TON: TON_0399
TGA: TGAM_1146(hmgA)
TSI: TSIB_0612
THE: GQS_03225
THA: TAM4_2137
THM: CL1_0345
TLT: OCC_04595
THS: TES1_0465
TNU: BD01_0308
TEU: TEU_07265
THH: CDI07_02645(hmgA)
PPAC: PAP_03560
MBAR: MSBR2_1683
MBAK: MSBR3_1674
MAC: MA_3073(hmgA)
MMA: MM_0335
MMAC: MSMAC_0968
METM: MSMTP_2268
MTHR: MSTHT_2527
MTHE: MSTHC_0758
MHOR: MSHOH_1143
MFZ: AOB57_002710(hmgA)
MBU: Mbur_1098
MMET: MCMEM_1587
MMH: Mmah_0566
MPY: Mpsy_2819
MZI: HWN40_08650(hmgA)
MHU: Mhun_3004
MLA: Mlab_1655
MBG: BN140_2503(hmgA)
MEMA: MMAB1_3364
MPI: Mpet_0546
MBN: Mboo_0137
MPL: Mpal_2647
MPD: MCP_3002(hmgA-2)
MEZ: Mtc_0456(hmgA-2)
RCI: RCIX1027(hmgA)
HAL: VNG_1875G(mvaA)
HSL: OE_3637R(hmgA)
HHB: Hhub_3224(hmgA)
HSU: HLASF_1924(hmgA)
HSF: HLASA_1910(hmgA)
SALR: FQU85_07365(hmgA)
HALR: EFA46_001930(hmgA)
HMA: rrnAC3412(mvaA)
HHI: HAH_0640(hmg)
HALJ: G9465_17050(hmgA)
NPH: NP_0368A(hmgA2) NP_2422A(hmgA1)
NMO: Nmlp_2407(hmgA)
HUT: Huta_0276
HTI: HTIA_0459
HALA: Hrd1104_06135(hmgA)
HMU: Hmuk_1499
HALZ: E5139_10630(hmgA)
HALL: LC1Hm_0815(hmg1)
HSN: DV733_04170(hmgA) DV733_04175(hmgA)
HRR: HZS55_02025(hmgA)
HPEL: HZS54_01690(hmgA)
HWA: HQ_3215A(hmgA)
HWC: Hqrw_3777(hmgA)
HVO: HVO_2583(hmgA)
HME: HFX_2609(hmgR)
HALE: G3A49_16610(hmgA)
HAQ: DU484_05000(hmgA)
HAJ: DU500_05440(hmgA)
HAER: DU502_03160(hmgA)
HRA: EI982_10175(hmgA)
HLM: DV707_03295(hmgA)
HALM: FCF25_02765(hmgA)
HLA: Hlac_2019
HALP: DOS48_10695(hmgA)
HALB: EKH57_14585(hmgA)
HEZZ: EO776_10075(hmgA)
HALQ: Hrr1229_009810(hmgA)
SRUB: C2R22_15940(hmgA)
HALN: B4589_010190(hmgA)
HALG: HUG10_01610(hmgA)
HALU: HUG12_15790(hmgA)
HTU: Htur_0537
HJT: DVR14_07455(hmgA)
HALY: HYG82_17865(hmgA)
NMG: Nmag_2929(hmgA)
NAT: NJ7G_4215
NVR: FEJ81_16145(hmgA)
NPL: FGF80_15215(hmgA)
SALI: L593_03550
NBG: DV706_08730(hmgA)
NAS: GCU68_03355(hmgA)
APE: APE_1869(hmgA)
ACJ: ACAM_1174(hmgA)
SMR: Smar_1337
IHO: Igni_0476
IIS: EYM_00605
DKA: DKAM_0388
HBU: Hbut_1531
STO: STK_13520(hmgA)
SOH: D1869_07615(hmgA)
SSO: SSO0531
SOL: Ssol_1610
SSOA: SULA_1637(hmgA)
SSOL: SULB_1638(hmgA)
SSOF: SULC_1636(hmgA)
SAI: Saci_1359
SID: M164_1581
SII: LD85_1792
SIH: SiH_1551
SIR: SiRe_1459
SIC: SiL_1461
MSE: Msed_1649
MCN: Mcup_0580
MHK: DFR87_10465(hmgA)
MPRU: DFR88_10025(hmgA)
MTEN: GWK48_01835(hmgA)
AHO: Ahos_1305
ASUL: DFR86_09305(hmgA)
AAMB: D1866_01440(hmgA)
SAZO: D1868_04870(hmgA)
STEP: IC006_1049
PAI: PAE2182
PIS: Pisl_0814
PCL: Pcal_1085
PAS: Pars_0796
PYR: P186_0419
POG: Pogu_1536
TNE: Tneu_1359
CMA: Cmaq_0412
TTN: TTX_0171(mvaA)
TUZ: TUZN_1176
VDI: Vdis_1666
VMO: VMUT_2295
ASC: ASAC_1038
ACIA: SE86_06315
MARH: Mia14_0330
 » show all
Reference
PMID:2991281
  Authors
Luskey KL, Stevens B
  Title
Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.
  Journal
J Biol Chem 260:10271-7 (1985)
  Sequence
[hsa:3156]
Reference
PMID:1556098
  Authors
Lam WL, Doolittle WF
  Title
Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii.
  Journal
J Biol Chem 267:5829-34 (1992)
  Sequence
[hvo:HVO_2583]
LinkDB

KEGG   ENZYME: 1.1.1.34
Entry
EC 1.1.1.34                 Enzyme                                 

Name
hydroxymethylglutaryl-CoA reductase (NADPH);
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl CoA reductase (NADPH);
S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
NADPH-hydroxymethylglutaryl-CoA reductase;
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA);
3-hydroxy-3-methylglutaryl CoA reductase (NADPH);
hydroxymethylglutaryl-CoA reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN:R02082]
Reaction(KEGG)
R02082
Substrate
(R)-mevalonate [CPD:C00418];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
History
EC 1.1.1.34 created 1961
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00021  hydroxymethylglutaryl-CoA reductase (NADPH)
Genes
HSA: 3156(HMGCR)
PTR: 471516(HMGCR)
PPS: 100990336(HMGCR)
GGO: 101136625(HMGCR)
PON: 100173499(HMGCR)
NLE: 100597442(HMGCR)
MCC: 705479(HMGCR)
MCF: 101926249(HMGCR)
CSAB: 103223243(HMGCR)
RRO: 104653755(HMGCR) 115895907 115896021 115896068
RBB: 108513080(HMGCR)
CJC: 100403990(HMGCR)
SBQ: 101033204(HMGCR)
MMU: 15357(Hmgcr)
MCAL: 110307857(Hmgcr)
MPAH: 110328787(Hmgcr)
RNO: 25675(Hmgcr)
CGE: 100756363(Hmgcr)
NGI: 103731354(Hmgcr)
HGL: 101717005(Hmgcr)
CCAN: 109700493(Hmgcr)
OCU: 100357791(HMGCR)
TUP: 102480274(HMGCR)
CFA: 479182(HMGCR)
VVP: 112919751(HMGCR)
AML: 100464316(HMGCR)
UMR: 103663564(HMGCR)
UAH: 113255200(HMGCR)
ORO: 101368294(HMGCR)
FCA: 101098922(HMGCR)
PTG: 102963640(HMGCR)
PPAD: 109274990(HMGCR)
AJU: 106974837(HMGCR)
BTA: 407159(HMGCR)
BOM: 102270355(HMGCR)
BIU: 109564640(HMGCR)
BBUB: 102394647(HMGCR)
CHX: 102169762(HMGCR)
OAS: 101108919(HMGCR)
SSC: 100144446(HMGCR)
CFR: 102507285(HMGCR)
CDK: 105084800(HMGCR)
LVE: 103081068(HMGCR)
OOR: 101275846(HMGCR)
DLE: 111185263(HMGCR)
PCAD: 102983040(HMGCR)
ECB: 100065577(HMGCR)
EPZ: 103555449(HMGCR)
EAI: 106824005(HMGCR)
MYB: 102262745(HMGCR)
MYD: 102767367(HMGCR)
MNA: 107531218(HMGCR)
HAI: 109381933(HMGCR)
DRO: 112307523(HMGCR)
PALE: 102890076(HMGCR)
RAY: 107506449(HMGCR)
MJV: 108408321(HMGCR)
LAV: 100661990(HMGCR)
TMU: 101360660
MDO: 100014439(HMGCR)
SHR: 100922433(HMGCR)
PCW: 110216572(HMGCR)
OAA: 100086613(HMGCR)
GGA: 395145(HMGCR)
MGP: 104915886(HMGCR)
CJO: 107306044(HMGCR)
NMEL: 110389857(HMGCR)
APLA: 101805369(HMGCR)
ACYG: 106042919(HMGCR)
TGU: 100228972(HMGCR)
LSR: 110471283(HMGCR)
SCAN: 103819488(HMGCR)
GFR: 102039836(HMGCR)
FAB: 101812070(HMGCR)
PHI: 102101959(HMGCR)
PMAJ: 107215886(HMGCR)
CCAE: 111940640(HMGCR)
CCW: 104685133(HMGCR)
ETL: 114057167(HMGCR)
FPG: 101915600(HMGCR)
FCH: 102052105(HMGCR)
CLV: 102088196(HMGCR)
EGZ: 104124861(HMGCR)
NNI: 104013038(HMGCR) 104017611
ACUN: 113490251(HMGCR)
PADL: 103919697(HMGCR)
AAM: 106489268
ASN: 102386377(HMGCR)
AMJ: 102571444(HMGCR)
PSS: 102459565(HMGCR)
CMY: 102947767(HMGCR)
CPIC: 101931267(HMGCR)
ACS: 100555648(hmgcr)
PVT: 110084573
PBI: 103059006(HMGCR)
PMUR: 107291177(HMGCR)
TSR: 106550050(HMGCR)
PMUA: 114606284(HMGCR)
GJA: 107118163(HMGCR)
XLA: 108707262(hmgcr.S) 397750(hmgcr.L)
XTR: 100380121(hmgcr)
NPR: 108796370(HMGCR)
DRE: 541479(hmgcrb) 559054(hmgcra)
IPU: 108255489(hmgcr) 108278928(HMGCR)
PHYP: 113535726 113536911(hmgcr)
EEE: 113573726 113574964(hmgcr)
TRU: 101066905(hmgcr) 101078757
LCO: 104926606 104937871(hmgcr)
NCC: 104951831 104964565(hmgcr)
XMA: 102229336 102237239(hmgcr)
XCO: 114149006 114155192(hmgcr)
PRET: 103470679(hmgcr) 103473284
CVG: 107090374 107093682(hmgcr)
CSEM: 103389902 103397369(hmgcr)
POV: 109626244 109640161(hmgcr)
LCF: 108873800 108878542(hmgcr)
HCQ: 109510552(hmgcr) 109525561
BPEC: 110157405 110172435(hmgcr)
SASA: 100380797(hmdh) 106570829(hmgcr)
OTW: 112220299
ELS: 105009321(hmgcr) 105015131
SFM: 108925108(hmgcr)
PKI: 111849962(hmgcr)
LCM: 102361998(HMGCR)
CMK: 103186373(hmgcr)
RTP: 109936281
BFO: 118410303
CIN: 100187175
SPU: 373355(HMGCR)
APLC: 110986789
SKO: 100369866
DME: Dmel_CG10367(Hmgcr)
DER: 6554339
DSE: 6607617
DSI: Dsimw501_GD21034(Dsim_GD21034)
DAN: 6499055
DSR: 110185563
DPE: 6587844
DMN: 108154668
DWI: 6649674
DAZ: 108621175
DNV: 108658955
DVI: 6630786
MDE: 101892909
LCQ: 111690994
AAG: 5571790
AME: 550724
BIM: 100746066
BTER: 100651787
CCAL: 108629833
OBB: 114875877
MPHA: 105831385
AEC: 105152804
ACEP: 105625102
PBAR: 105429601
HST: 105189357
DQU: 106746505
CFO: 105256970
LHU: 105667949
PGC: 109859982
OBO: 105283012
PCF: 106788979
NVI: 100117068
CSOL: 105363952
MDL: 103572658
BMOR: 100101204(Hmg-r)
BMAN: 114252510
PMAC: 106715604
PRAP: 110997222
HAW: 110382245
PXY: 105398578
DNX: 107170987
AGS: 114121337
RMD: 113557321
ZNE: 110835092
DPX: DAPPUDRAFT_346929(Hmgcr)
PVM: 113803763
TUT: 107360294
DPTE: 113798075
CSCU: 111640814
PTEP: 107444292
CEL: CELE_F08F8.2(hmgr-1)
CBR: CBG15296
BMY: Bm1_54020
TSP: Tsp_10921
PCAN: 112553957
CRG: 105320820
MYI: 110454220
OBI: 106880618
LAK: 106162017
SHX: MS3_08471
NVE: 5508715
EPA: 110243168
ADF: 107344111
AMIL: 114954020
PDAM: 113672697
SPIS: 111330985
DGT: 114522592
HMG: 100215451
AQU: 100635846
ATH: AT1G76490(HMG1) AT2G17370(HMG2)
LJA: Lj0g3v0018799.1(Lj0g3v0018799.1) Lj0g3v0268939.1(Lj0g3v0268939.1) Lj2g3v1574250.1(Lj2g3v1574250.1) Lj2g3v2948500.1(Lj2g3v2948500.1)
BVG: 104904096
DOSA: Os02t0713900-01(Os02g0713900) Os08t0512700-01(Os08g0512700) Os09t0492700-01(Os09g0492700)
ATS: 109746630(LOC109746630) 109752372(LOC109752372) 109782286(LOC109782286)
ATR: 18439724
SCE: YLR450W(HMG2) YML075C(HMG1)
ERC: Ecym_1136
KMX: KLMA_40445(HMG1)
NCS: NCAS_0A06180(NCAS0A06180)
NDI: NDAI_0D03170(NDAI0D03170)
TPF: TPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBL: TBLA_0E04740(TBLA0E04740)
TDL: TDEL_0D00740(TDEL0D00740)
KAF: KAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
PIC: PICST_72872(HMG1)
CAL: CAALFM_C103780CA(HMG1)
SLB: AWJ20_1837(HMG1)
NCR: NCU00712
NTE: NEUTE1DRAFT89746(NEUTE1DRAFT_89746)
MGR: MGG_08975
SSCK: SPSK_01389
FPU: FPSE_03466(HMR1)
NHE: NECHADRAFT_105420(NhHMR1)
MAW: MAC_02791
MAJ: MAA_05256
CMT: CCM_04994
MBE: MBM_03374
ANG: ANI_1_1022064(An07g08280) ANI_1_1548184(An04g00610)
ABE: ARB_00275
TVE: TRV_00650
PTE: PTT_07524
ZTR: MYCGRDRAFT_64888(HMG1)
SPO: SPCC162.09c(hmg1)
CNE: CNF04830
CNB: CNBF0070
TASA: A1Q1_01564
ABP: AGABI1DRAFT64187(AGABI1DRAFT_64187)
ABV: AGABI2DRAFT208992(AGABI2DRAFT_208992)
MGL: MGL_3624
MRT: MRET_0384
DDI: DDB_G0269142(hmgA) DDB_G0276615(hmgB)
DFA: DFA_02965(hmgB) DFA_07220
SPAR: SPRG_01272
LMA: LMJF_30_3190(HMGR)
LIF: LINJ_30_3230(HMGR)
LPAN: LPMP_303150(HMGR)
PLU: plu4507
VCH: VCA0723
VCS: MS6_A0769
VCE: Vch1786_II0408(hmgA)
VCI: O3Y_16913
VCR: VC395_A0589(hmgA)
VCM: VCM66_A0681(hmgA)
VVU: VV2_0117
VVY: VVA0625
VPA: VPA0968
VAG: N646_4347
VSP: VS_II0457
VAN: VAA_01552
VAU: VANGNB10_cII0695(hmgA)
VTA: B0124(hmgA)
VFI: VF_A0841
PSIL: PMA3_24025
PAT: Patl_0427
GNI: GNIT_1294(hmg1)
MVS: MVIS_1670(hmgA)
SAGA: M5M_16240
CBD: CBUD_0151 CBUD_0622(hmgA)
CBG: CbuG_0298 CbuG_1393(hmgA)
CBC: CbuK_0218 CbuK_1440(hmgA)
CEY: CleRT_04160(hmgA)
TCX: Tcr_1717
HMAR: HVMH_0539
DNO: DNO_0797
SVA: SVA_3750
CVI: CV_1806
BOK: DM82_1348
BOC: BG90_3346
LAA: WSI_04450
LSO: CKC_03800
LAR: lam_722(hMG1)
MALU: KU6B_29570
GAK: X907_0130
SAY: TPY_0167
MUL: MUL_3522
MMI: MMAR_3214
CKP: ckrop_0031(mvaA)
CVA: CVAR_1983(mvaA)
CTER: A606_07960
COA: DR71_1489
NFA: NFA_22110
SDV: BN159_7954(hmgA3)
STRE: GZL_00237
SFK: KY5_0603c
IDO: I598_0505
BSD: BLASA_0285(hmgA)
SEN: SACE_5541
SACG: FDZ84_37460(panC)
GBA: J421_4295
SRU: SRU_2422
SRM: SRM_02640(hmgA)
SGN: SGRA_2249
FAE: FAES_4555(hmgA)
HSW: Hsw_4017
FLM: MY04_1691
CPRV: CYPRO_0371
MJA: MJ_0705
MMP: MMP0087(hmgA)
MMD: GYY_00445
MMAK: MMKA1_00920(hmgA)
MMAO: MMOS7_01170(hmgA)
MMAD: MMJJ_10070
MAE: Maeo_0718
MVO: Mvol_1440
METF: CFE53_04475(hmgA)
MTH: MTH_562
MMG: MTBMA_c09500(hmgA)
METC: MTCT_0489
MWO: MWSIV6_0926(hmgA)
METE: tca_00533
METK: FVF72_08715(hmgA)
MTHM: FZP57_04445(hmgA)
MST: Msp_0584(hmgA)
MRU: mru_1092(hmgA)
MSI: Msm_0227
MEB: Abm4_0894(hmgA)
MMIL: sm9_0824(hmgA)
MEYE: TL18_06175
MOL: YLM1_0775
METH: MBMB1_1357(hmgA)
MFC: BRM9_0582(hmgA)
MFI: DSM1535_0563(hmgA)
MCUB: MCBB_1594(hmgA)
METT: CIT01_10430(hmgA)
METO: CIT02_11195(hmgA)
MFV: Mfer_0012
MKA: MK0355(hmg1)
MEAR: Mpt1_c04890(hmgA)
MARC: AR505_0768
PFU: PF1848
PFI: PFC_09350
PHO: PH1805(PH1805)
PAB: PAB2106
PYN: PNA2_0404
PYS: Py04_1729
TKO: TK0914
TON: TON_0399
TGA: TGAM_1146(hmgA)
TSI: TSIB_0612
THE: GQS_03225
THA: TAM4_2137
THM: CL1_0345
TLT: OCC_04595
THS: TES1_0465
TNU: BD01_0308
TEU: TEU_07265
THH: CDI07_02645(hmgA)
PPAC: PAP_03560
MBAR: MSBR2_1683
MBAK: MSBR3_1674
MAC: MA_3073(hmgA)
MMA: MM_0335
MMAC: MSMAC_0968
METM: MSMTP_2268
MTHR: MSTHT_2527
MTHE: MSTHC_0758
MHOR: MSHOH_1143
MFZ: AOB57_002710(hmgA)
MBU: Mbur_1098
MMET: MCMEM_1587
MMH: Mmah_0566
MPY: Mpsy_2819
MZI: HWN40_08650(hmgA)
MHU: Mhun_3004
MLA: Mlab_1655
MBG: BN140_2503(hmgA)
MEMA: MMAB1_3364
MPI: Mpet_0546
MBN: Mboo_0137
MPL: Mpal_2647
MPD: MCP_3002(hmgA-2)
MEZ: Mtc_0456(hmgA-2)
RCI: RCIX1027(hmgA)
HAL: VNG_1875G(mvaA)
HSL: OE_3637R(hmgA)
HHB: Hhub_3224(hmgA)
HSU: HLASF_1924(hmgA)
HSF: HLASA_1910(hmgA)
SALR: FQU85_07365(hmgA)
HALR: EFA46_001930(hmgA)
HMA: rrnAC3412(mvaA)
HHI: HAH_0640(hmg)
HALJ: G9465_17050(hmgA)
NPH: NP_0368A(hmgA2) NP_2422A(hmgA1)
NMO: Nmlp_2407(hmgA)
HUT: Huta_0276
HTI: HTIA_0459
HALA: Hrd1104_06135(hmgA)
HMU: Hmuk_1499
HALZ: E5139_10630(hmgA)
HALL: LC1Hm_0815(hmg1)
HSN: DV733_04170(hmgA) DV733_04175(hmgA)
HRR: HZS55_02025(hmgA)
HPEL: HZS54_01690(hmgA)
HWA: HQ_3215A(hmgA)
HWC: Hqrw_3777(hmgA)
HVO: HVO_2583(hmgA)
HME: HFX_2609(hmgR)
HALE: G3A49_16610(hmgA)
HAQ: DU484_05000(hmgA)
HAJ: DU500_05440(hmgA)
HAER: DU502_03160(hmgA)
HRA: EI982_10175(hmgA)
HLM: DV707_03295(hmgA)
HALM: FCF25_02765(hmgA)
HLA: Hlac_2019
HALP: DOS48_10695(hmgA)
HALB: EKH57_14585(hmgA)
HEZZ: EO776_10075(hmgA)
HALQ: Hrr1229_009810(hmgA)
SRUB: C2R22_15940(hmgA)
HALN: B4589_010190(hmgA)
HALG: HUG10_01610(hmgA)
HALU: HUG12_15790(hmgA)
HTU: Htur_0537
HJT: DVR14_07455(hmgA)
HALY: HYG82_17865(hmgA)
NMG: Nmag_2929(hmgA)
NAT: NJ7G_4215
NVR: FEJ81_16145(hmgA)
NPL: FGF80_15215(hmgA)
SALI: L593_03550
NBG: DV706_08730(hmgA)
NAS: GCU68_03355(hmgA)
APE: APE_1869(hmgA)
ACJ: ACAM_1174(hmgA)
SMR: Smar_1337
IHO: Igni_0476
IIS: EYM_00605
DKA: DKAM_0388
HBU: Hbut_1531
STO: STK_13520(hmgA)
SOH: D1869_07615(hmgA)
SSO: SSO0531
SOL: Ssol_1610
SSOA: SULA_1637(hmgA)
SSOL: SULB_1638(hmgA)
SSOF: SULC_1636(hmgA)
SAI: Saci_1359
SID: M164_1581
SII: LD85_1792
SIH: SiH_1551
SIR: SiRe_1459
SIC: SiL_1461
MSE: Msed_1649
MCN: Mcup_0580
MHK: DFR87_10465(hmgA)
MPRU: DFR88_10025(hmgA)
MTEN: GWK48_01835(hmgA)
AHO: Ahos_1305
ASUL: DFR86_09305(hmgA)
AAMB: D1866_01440(hmgA)
SAZO: D1868_04870(hmgA)
STEP: IC006_1049
PAI: PAE2182
PIS: Pisl_0814
PCL: Pcal_1085
PAS: Pars_0796
PYR: P186_0419
POG: Pogu_1536
TNE: Tneu_1359
CMA: Cmaq_0412
TTN: TTX_0171(mvaA)
TUZ: TUZN_1176
VDI: Vdis_1666
VMO: VMUT_2295
ASC: ASAC_1038
ACIA: SE86_06315
MARH: Mia14_0330
 » show all
Reference
1  [PMID:13805544]
  Authors
BUCHER NL, OVERATH P, LYNEN F
  Title
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
  Journal
Biochim Biophys Acta 40:491-501 (1960)
DOI:10.1016/0006-3002(60)91390-1
Reference
2  [PMID:13818862]
  Authors
DURR IF, RUDNEY H.
  Title
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid.
  Journal
J Biol Chem 235:2572-8 (1960)
Reference
3  [PMID:4985697]
  Authors
Kawachi T, Rudney H.
  Title
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver.
  Journal
Biochemistry 9:1700-5 (1970)
DOI:10.1021/bi00810a008
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.34
IUBMB Enzyme Nomenclature: 1.1.1.34
ExPASy - ENZYME nomenclature database: 1.1.1.34
BRENDA, the Enzyme Database: 1.1.1.34
CAS: 9028-35-7
LinkDB

KEGG   REACTION: R02082
Entry
R02082                      Reaction                               

Name
(R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
Definition
(R)-Mevalonate + CoA + 2 NADP+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Equation
C00418 + C00010 + 2 C00006 <=> C00356 + 2 C00005 + 2 C00080
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00356
RC00644  C00356_C00418
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Other DBs
RHEA: 15992
LinkDB

DBGET integrated database retrieval system