KEGG   ORTHOLOGY: K00070Help
Entry
K00070                      KO                                     

Name
HSD3B
Definition
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Pathway
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko04913  Ovarian steroidogenesis
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04934  Cushing syndrome
Module
M00107  Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216  Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04925 Aldosterone synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04927 Cortisol synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
BRITE hierarchy
Other DBs
RN: R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849
GO: 0003854 0004769
Genes
HSA: 3283(HSD3B1) 3284(HSD3B2)
PTR: 457165 469446
PPS: 100982464(HSD3B2) 100983009 100990187
GGO: 101141801 101146563(HSD3B2)
PON: 100451655 100452394
NLE: 100596087 100605995(HSD3B2) 100606563(HSD3B1) 100607955
MCC: 712686(HSD3B2) 713091
MCF: 102129497 102133592(HSD3B1) 102134747 102135110
CSAB: 103224100(HSD3B1) 103224104 103224107 103224109(HSD3B2)
RRO: 104654599 104654605
MMU: 100043456(Gm10681) 15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)
RNO: 108348086 24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)
HGL: 101707488(Hsd3b1) 101707858
CFA: 483146(HSD3B2)
VVP: 112916789
AML: 100464280(HSD3B1)
UMR: 103677123
UAH: 113244362
ORO: 101378904
FCA: 100616070(HSD3B2)
PTG: 102957262
PPAD: 109272160
AJU: 106978496
BTA: 281824(HSD3B1)
BOM: 102274088
BIU: 109555859
BBUB: 102413429
CHX: 100860869(3BHSD)
OAS: 100190978(HSD3B1)
SSC: 445539(HSD3B1)
CFR: 102512447
CDK: 105089475
BACU: 103015346
LVE: 103083046
OOR: 101284283
DLE: 111179902
PCAD: 102987751
ECB: 100034078(HSD3B2)
EPZ: 103548379
EAI: 106832920(HSD3B2)
MYB: 106723550(HSD3B2)
MNA: 107545288(HSD3B2)
HAI: 109389868(HSD3B2)
DRO: 112314004(HSD3B2)
PALE: 102891879
RAY: 107518830(HSD3B2)
MJV: 108390800
LAV: 100659049(HSD3B2)
TMU: 101358325
MDO: 100012668
SHR: 100913530(HSD3B2)
PCW: 110219672(HSD3B2)
OAA: 100080135
GGA: 396015(HSD3B1)
MGP: 104915630
CJO: 107319373(3beta-HSD)
NMEL: 110398845
APLA: 101803865
ACYG: 106045741
TGU: 751770(HSD3B1)
LSR: 110480744
SCAN: 103827136
GFR: 102039409
FAB: 101817697
PHI: 102101526
PMAJ: 107211459
CCAE: 111938581
CCW: 104687106
ETL: 114058198
FPG: 101921564
FCH: 102052697
CLV: 102087460
EGZ: 104126518
NNI: 104008615
ACUN: 113485872
PADL: 103921223
AAM: 106497227
ASN: 102367786(HSD3B1)
AMJ: 109280168(HSD3B1)
PSS: 102453952
CMY: 102934871
CPIC: 101946936
ACS: 100561899(hsd3b1)
PVT: 110076926
PBI: 103067418
PMUR: 107285816
TSR: 106542700
PMUA: 114587929(HSD3B2)
GJA: 107114856
XLA: 734818(hsd3b1.L)
XTR: 100490622
NPR: 108802532
DRE: 373131(hsd3b2) 553532(hsd3b1)
SRX: 107712267
SANH: 107658243
SGH: 107569293
CCAR: 109052439
IPU: 100304475(HSD3B)
PHYP: 113524942(hsd3b1)
AMEX: 103027852(hsd3b1)
EEE: 113587753
TRU: 101069884(hsd3b1)
LCO: 104921488(hsd3b1)
MZE: 101485719
ONL: 100534568
OLA: 100144358(3bhsd)
XMA: 102228303
XCO: 114147930
PRET: 103477979
CVG: 107087352
NFU: 107389612(hsd3b1)
KMR: 108244192(hsd3b1)
ALIM: 106531920
AOCE: 111570570(hsd3b1)
CSEM: 103391994(hsd3b1)
POV: 109637945
LCF: 108902437
SDU: 111218347
SLAL: 111652102
HCQ: 109522071
BPEC: 110156192(hsd3b1)
MALB: 109951646
SASA: 106586600
OTW: 112240651
SALP: 111978723
ELS: 105016430
SFM: 108937872
PKI: 111860692
LCM: 102345588
CMK: 103180179
RTP: 109918392
DME: Dmel_CG7724(CG7724)
DER: 6543694
DSI: Dsimw501_GD14693(Dsim_GD14693)
DPE: 6603899
DWI: 6645028
DAZ: 108612818
DNV: 108651018
DHE: 111602930
MDE: 101899660
LCQ: 111691019
AAG: 5566270
NVI: 100120136
CSOL: 105366624
CLEC: 106661338
ZNE: 110831195
FCD: 110862702
PVM: 113815316
TUT: 107363285
DPTE: 113794090
CSCU: 111622487
PTEP: 107437550
MYI: 110457155
LAK: 106151343
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2243100
  Authors
Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guerin S, Leblanc G, Labrie F
  Title
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.
  Journal
J Biol Chem 265:20469-75 (1990)
  Sequence
[hsa:3283] [rno:360348 682974]
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