KEGG   ORTHOLOGY: K00071
Entry
K00071                      KO                                     

Name
HSD11B2
Definition
corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]
Pathway
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko04960  Aldosterone-regulated sodium reabsorption
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00259  Apparent mineralocorticoid excess syndrome
H01633  High blood pressure
H01709  Glucocorticoid-induced osteonecrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00071  HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00071  HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K00071  HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2
Other DBs
RN: R02834 R03847
Genes
HSA: 3291(HSD11B2)
PTR: 468001(HSD11B2)
PPS: 100993079(HSD11B2)
GGO: 101153708(HSD11B2)
PON: 100443811(HSD11B2)
NLE: 100602616(HSD11B2)
MCC: 574396(HSD11B2)
MCF: 102115494(HSD11B2)
CSAB: 103233278(HSD11B2)
RRO: 104655689(HSD11B2)
RBB: 108515358(HSD11B2) 108525856
CJC: 100385196(HSD11B2)
SBQ: 101046859(HSD11B2)
MMU: 15484(Hsd11b2)
MCAL: 110300601(Hsd11b2)
MPAH: 110337576(Hsd11b2)
RNO: 25117(Hsd11b2)
MUN: 110545706(Hsd11b2)
CGE: 100766725(Hsd11b2)
NGI: 103738923(Hsd11b2)
HGL: 101712460(Hsd11b2)
CCAN: 109691244(Hsd11b2)
OCU: 100009531(HSD11B2)
TUP: 102494408(HSD11B2)
CFA: 489758(HSD11B2)
VVP: 112929518(HSD11B2)
AML: 100473624(HSD11B2)
UMR: 103673726(HSD11B2)
UAH: 113252365(HSD11B2)
ORO: 101363668(HSD11B2)
ELK: 111152836
FCA: 100529249(HSD11B2)
PTG: 102969498(HSD11B2)
PPAD: 109270765(HSD11B2)
AJU: 106972318(HSD11B2)
BTA: 282434(HSD11B2)
BOM: 102284703(HSD11B2)
BIU: 109572237(HSD11B2)
BBUB: 102409353(HSD11B2)
CHX: 102183447(HSD11B2)
OAS: 443530(HSD11B2)
SSC: 396948(HSD11B2)
CFR: 102516692(HSD11B2)
CDK: 105088484(HSD11B2)
BACU: 103015303(HSD11B2)
LVE: 103078561(HSD11B2)
OOR: 101289432(HSD11B2)
DLE: 111179633(HSD11B2)
PCAD: 102976970(HSD11B2)
ECB: 100034124(HSD11B2)
EPZ: 103542727(HSD11B2)
EAI: 106822426(HSD11B2)
MYB: 102247970(HSD11B2)
MYD: 102767517(HSD11B2)
MNA: 107542883(HSD11B2)
HAI: 109388643(HSD11B2)
DRO: 112300862(HSD11B2)
PALE: 102897175(HSD11B2)
RAY: 107520210(HSD11B2)
MJV: 108390360(HSD11B2)
LAV: 100660892(HSD11B2)
TMU: 101359521
MDO: 103100097(HSD11B2)
SHR: 116421329(HSD11B2)
PCW: 110210411(HSD11B2)
OAA: 100081477(HSD11B2)
GGA: 100858361(HSD11B2)
MGP: 100548201(HSD11B2)
CJO: 107319159(HSD11B2)
NMEL: 110404219(HSD11B2)
APLA: 101790751(HSD11B2)
ACYG: 106033128(HSD11B2)
TGU: 100222854(HSD11B2)
LSR: 110476218(HSD11B2)
SCAN: 103816835(HSD11B2)
GFR: 102043738(HSD11B2)
FAB: 101815475(HSD11B2)
PHI: 102111344(HSD11B2)
PMAJ: 107209832(HSD11B2)
CCAE: 111934511(HSD11B2)
CCW: 104691776(HSD11B2)
ETL: 114063449(HSD11B2)
FPG: 101912301(HSD11B2)
FCH: 102059634(HSD11B2)
CLV: 102085620(HSD11B2)
EGZ: 104130298(HSD11B2)
NNI: 104017487(HSD11B2)
ACUN: 113484560(HSD11B2)
PADL: 103922269(HSD11B2)
AAM: 106484515
ASN: 102377421(HSD11B2)
AMJ: 102567313(HSD11B2)
PSS: 102451930(HSD11B2)
CMY: 102944464(HSD11B2)
CPIC: 101949646(HSD11B2)
ACS: 100564096
PVT: 110081292
PBI: 103054046(HSD11B2)
PMUR: 107284155(HSD11B2)
TSR: 106551703(HSD11B2)
PMUA: 114601878(HSD11B2)
GJA: 107108017(HSD11B2)
XLA: 444491(hsd11b2.L)
XTR: 100489854(hsd11b2)
NPR: 108789587(HSD11B2)
DRE: 334098(hsd11b2)
CCAR: 109051628(hsd11b2) 109054113 109060187
IPU: 108259637(hsd11b2)
PHYP: 113540912(hsd11b2)
AMEX: 103026519(hsd11b2)
EEE: 113582733(hsd11b2)
TRU: 101064958
LCO: 104939420
MZE: 101471311
ONL: 100534505(hsd11b2)
OLA: 100125474
XCO: 114142819
NFU: 107381516(hsd11b2)
KMR: 108247994(hsd11b2)
ALIM: 106532172
AOCE: 111567954(hsd11b2)
CSEM: 103378825(hsd11b2)
LCF: 108894260
SDU: 111225487(hsd11b2)
SLAL: 111652849
HCQ: 109529762(hsd11b2)
BPEC: 110169004
MALB: 109961670(hsd11b2)
ELS: 105025474(hsd11b2)
LCM: 102360976(HSD11B2)
CMK: 103190838
RTP: 109915214
 » show all
Reference
  Authors
Gong R, Morris DJ, Brem AS
  Title
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells.
  Journal
Steroids 73:1187-96 (2008)
DOI:10.1016/j.steroids.2008.05.009
  Sequence
[hsa:3291]
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