KEGG   ORTHOLOGY: K00089
Entry
K00089                      KO                                     
Symbol
AKR1C2
Name
3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Reaction
R02476  androsterone:NAD+ oxidoreductase
R02477  androsterone:NADP+ oxidoreductase
R04330  androstan-3alpha,17beta-diol:NAD+ oxidoreductase
R08955  3alpha,21-dihydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08957  3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08960  5alpha-pregnane-3alpha,20alpha-diol:NADP+ oxidoreductase (A-specific)
R08963  androstan-3alpha,17beta-diol:NADP+ oxidoreductase
R13216  5alpha-pregnane-3alpha,17alpha-diol-20-one:NAD+ oxidoreductase
R13217  5alpha-pregnane-3alpha,17alpha-diol-20-one:NADP+ 3-oxidoreductase
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
   05208 Chemical carcinogenesis - reactive oxygen species
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Other DBs
GO: 0047026
Genes
HSA: 1646(AKR1C2)
PTR: 100612191(AKR1C2)
PPS: 103783188
NLE: 100603603
HMH: 116457046
SSYN: 129491832
DNM: 101429786
Reference
PMID:7998972
  Authors
Del Bello B, Maellaro E, Sugherini L, Santucci A, Comporti M, Casini AF
  Title
Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem J 304 ( Pt 2):385-90 (1994)
DOI:10.1042/bj3040385
Reference
PMID:8274401
  Authors
Qin KN, New MI, Cheng KC
  Title
Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
  Journal
J Steroid Biochem Mol Biol 46:673-9 (1993)
DOI:10.1016/0960-0760(93)90308-j
  Sequence
[hsa:1646]
LinkDB

KEGG   ORTHOLOGY: K04119
Entry
K04119                      KO                                     
Symbol
AKR1C3
Name
aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00790  Folate biosynthesis
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05208  Chemical carcinogenesis - reactive oxygen species
Module
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Reaction
R01836  testosterone:NAD+ 17-oxidoreductase
R01838  testosterone:NADP+ 17-oxidoreductase
R02352  estradiol-17beta:NAD+ 17-oxidoreductase
R02353  estradiol-17beta:NADP+ 17-oxidoreductase
R02799  11-epi-prostaglandin F2alpha:NADP+ 11-oxidoreductase
R03406  androst-5-ene-3beta,17beta-diol:NAD+ oxidoreductase
R03407  androst-5-ene-3beta,17beta-diol:NADP+ oxidoreductase
R08955  3alpha,21-dihydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08957  3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08960  5alpha-pregnane-3alpha,20alpha-diol:NADP+ oxidoreductase (A-specific)
R11763  6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin:NADP+ oxidoreductase
R13039  
R13219  androstan-3alpha,17beta-diol:NADP+ 17-oxidoreductase
R13220  dihydrotestosterone:NADP+ 17-oxidoreductase
R13221  dihydrotestosterone:NAD+ 17-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
   00590 Arachidonic acid metabolism
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.188  prostaglandin-F synthase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
Other DBs
GO: 0030283 0047017 0047026
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878(AKR1C3) 101147265(AKR1C8) 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
PPYG: 129006137 129006869 129006873 129006874(AKR1C8)
NLE: 100593325 100604844 100606512
HMH: 116457717 116460197(AKR1C8)
SSYN: 129491831 129491837 129491838
MCC: 100430336 711440 722485 722496
MCAL: 110308148
RNO: 361267(Akr1c15)
MCOC: 116081731
ANU: 117713832
MUN: 110560700
MAUA: 101841267
PROB: 127229800
PLEU: 114708096
HGL: 101702106
CPOC: 100727454
DSP: 122113031
PLOP: 125366785
OCU: 108176284
CFA: 497070(AKR1C3)
CLUD: 112658979
VVP: 112933725
VLG: 121496638
NPO: 129514265
AML: 100483758
UMR: 103676234
UAH: 113241124
UAR: 123802294(AKR1C8)
ELK: 111158636
LLV: 125107753
MPUF: 101678776
MNP: 132020017
MLK: 131838054
NVS: 122891768(AKR1C4)
EJU: 114217720
ZCA: 113921662
FCA: 100510801(AKR1C3)
PYU: 121014878
PCOO: 112867557
PBG: 122473163
PVIV: 125169528
LRUF: 124502362
PTG: 102963188
PPAD: 109273789
PUC: 125918575
AJU: 106988139
HHV: 120237198
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
LVE: 103069218
PCAD: 102978533
SHON: 118977133
AJM: 119057712
PDIC: 114492418
PHAS: 123824859 123831227(AKR1C8)
HAI: 109378613
PALE: 102889546
PGIG: 120608988
PVP: 105299187
SETR: 126013285
CCAY: 125625831
TST: 117882842
CABI: 116815619
GJA: 107108026
EMC: 129335705
XLA: 100049750(XB5895996.L) 443571(akr1c3.L)
CPLA: 122559456
HOC: 132825023
PPYR: 116168970
DMK: 116918341
PMEO: 129593135
MCAF: 127727738
MMER: 123536211
 » show all
Reference
PMID:7650035
  Authors
Khanna M, Qin KN, Wang RW, Cheng KC
  Title
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 270:20162-8 (1995)
DOI:10.1074/jbc.270.34.20162
  Sequence
[hsa:8644]
Reference
  Authors
Qiu W, Zhou M, Labrie F, Lin SX
  Title
Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.
  Journal
Mol Endocrinol 18:1798-807 (2004)
DOI:10.1210/me.2004-0032
Reference
  Authors
Komoto J, Yamada T, Watanabe K, Takusagawa F
  Title
Crystal structure of human prostaglandin F synthase (AKR1C3).
  Journal
Biochemistry 43:2188-98 (2004)
DOI:10.1021/bi036046x
Reference
  Authors
Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N
  Title
Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
  Journal
Mol Cell Endocrinol 171:137-49 (2001)
DOI:10.1016/S0303-7207(00)00426-3
Reference
  Authors
Penning TM
  Title
New frontiers in androgen biosynthesis and metabolism.
  Journal
Curr Opin Endocrinol Diabetes Obes 17:233-9 (2010)
DOI:10.1097/MED.0b013e3283381a31
Reference
  Authors
Rizner TL, Penning TM
  Title
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
  Journal
Steroids 79:49-63 (2014)
DOI:10.1016/j.steroids.2013.10.012
LinkDB

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