KEGG   ORTHOLOGY: K00106
Entry
K00106                      KO                                     

Name
XDH
Definition
xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]
Pathway
ko00230  Purine metabolism
ko00232  Caffeine metabolism
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko04146  Peroxisome
Module
M00546  Purine degradation, xanthine => urea
Disease
H00192  Xanthinuria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K00106  XDH; xanthine dehydrogenase/oxidase
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K00106  XDH; xanthine dehydrogenase/oxidase
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K00106  XDH; xanthine dehydrogenase/oxidase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K00106  XDH; xanthine dehydrogenase/oxidase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00106  XDH; xanthine dehydrogenase/oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.1  With NAD+ or NADP+ as acceptor
    1.17.1.4  xanthine dehydrogenase
     K00106  XDH; xanthine dehydrogenase/oxidase
   1.17.3  With oxygen as acceptor
    1.17.3.2  xanthine oxidase
     K00106  XDH; xanthine dehydrogenase/oxidase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   K00106  XDH; xanthine dehydrogenase/oxidase
Other DBs
RN: R01768 R01769 R02103 R02107 R07942 R07977 R07978 R07979 R08235
GO: 0004854 0004855
Genes
HSA: 7498(XDH)
PTR: 470347(XDH)
PPS: 100986628(XDH)
GGO: 101138402(XDH)
PON: 100454383(XDH)
NLE: 100594931(XDH)
MCC: 708046(XDH)
MCF: 102116275(XDH)
CSAB: 103220539(XDH)
RRO: 104659929(XDH)
RBB: 108516631(XDH)
CJC: 100414932(XDH)
SBQ: 101044169(XDH)
MMU: 22436(Xdh)
MCAL: 110312137(Xdh)
MPAH: 110335495(Xdh)
RNO: 497811(Xdh)
MUN: 110557067(Xdh)
CGE: 100766626(Xdh)
NGI: 103748365(Xdh)
HGL: 101708017(Xdh)
CCAN: 109701710(Xdh)
OCU: 100144327(XDH)
TUP: 102477455(XDH)
CFA: 483028(XDH)
VVP: 112933009(XDH)
AML: 100465942(XDH)
UMR: 103671606(XDH)
UAH: 113240940(XDH)
ORO: 101376175(XDH)
ELK: 111154104
FCA: 105259797 493692(XDH)
PTG: 102969928
PPAD: 109261405 109262396(XDH)
AJU: 106967886(XDH)
BTA: 280960(XDH)
BOM: 102264420(XDH)
BIU: 109565958(XDH)
BBUB: 102406968(XDH)
CHX: 100861280(XDH)
OAS: 780499(XDH)
SSC: 100515259(XDH)
CFR: 102523581(XDH)
CDK: 105095605(XDH)
BACU: 103004564(XDH)
LVE: 103084498(XDH)
OOR: 101284574(XDH)
DLE: 111174909(XDH)
PCAD: 102980160(XDH)
MYB: 102262378(XDH)
MYD: 102773370(XDH)
MNA: 107541765(XDH)
HAI: 109395899
DRO: 112297809(XDH)
PALE: 102884734(XDH)
RAY: 107505738(XDH)
MJV: 108404078(XDH)
LAV: 100672640(XDH)
TMU: 101349074
MDO: 100031481(XDH)
SHR: 100933358(XDH)
PCW: 110198166(XDH)
GGA: 396025(XDH)
MGP: 100544067(XDH)
CJO: 107310773(XDH)
NMEL: 110395607(XDH)
APLA: 101799192(XDH)
ACYG: 106031596(XDH)
TGU: 100222890(XDH)
LSR: 110473976(XDH)
SCAN: 103821303(XDH)
GFR: 102040336(XDH)
FAB: 101819038(XDH)
PHI: 102106931(XDH)
PMAJ: 107201507(XDH)
CCAE: 111926289(XDH)
CCW: 104685575(XDH)
ETL: 114073409(XDH)
FPG: 101918653(XDH)
FCH: 102052812(XDH)
CLV: 102092037(XDH)
EGZ: 104134615(XDH)
NNI: 104019267(XDH)
ACUN: 113478412(XDH)
PADL: 103925004(XDH)
AAM: 106482734(XDH)
ASN: 102374197(XDH)
AMJ: 102564016(XDH)
PSS: 102461631(XDH)
CMY: 102945230(XDH)
CPIC: 101953114(XDH)
ACS: 100566790(xdh)
PVT: 110087557(XDH)
PBI: 103056546(XDH)
PMUR: 107297206(XDH)
TSR: 106538731(XDH)
PMUA: 114594599(XDH)
GJA: 107112582(XDH)
XLA: 108716095(xdh.L) 108717383
XTR: 100497499(xdh)
NPR: 108796807(XDH)
DRE: 560486(xdh)
SANH: 107674096 107697780(xdh)
CCAR: 109084316 109107555(xdh)
IPU: 108269840(xdh)
PHYP: 113533982(xdh)
AMEX: 103031284(xdh)
EEE: 113583665(xdh)
TRU: 101073141(xdh)
LCO: 104938633
MZE: 101478907(xdh)
ONL: 100706331(xdh)
OLA: 101162508(xdh)
XMA: 102231285(xdh)
XCO: 114140507(xdh)
PRET: 103481416(xdh)
CVG: 107104320(xdh)
NFU: 107384577(xdh)
KMR: 108251278(xdh)
ALIM: 106531265(xdh)
AOCE: 111587270(xdh)
CSEM: 103389795(xdh)
LCF: 108877173(xdh)
SDU: 111235538(xdh)
SLAL: 111646897(xdh)
HCQ: 109510392(xdh)
BPEC: 110166494(xdh)
SASA: 100380763(xdh)
OTW: 112262239
SALP: 112071841
ELS: 105031569(xdh)
SFM: 108923027(xdh)
PKI: 111834729(xdh)
CMK: 103182679 103187630(xdh)
RTP: 109913754(xdh) 109930681
DSI: Dsimw501_GD18875(Dsim_ry) Dsimw501_GD20335(Dsim_GD20335) Dsimw501_GD20336(Dsim_GD20336) Dsimw501_GD20337(Dsim_GD20337) Dsimw501_GD20338(Dsim_GD20338)
DPA: 109536954
API: 100169249
DNX: 107172284
AGS: 114119532
RMD: 113550991
CEL: CELE_F55B11.1(xdh-1)
ATH: AT4G34890(XDH1) AT4G34900(XDH2)
CRB: 17877660
THJ: 104817905
CPAP: 110811823
CIT: 102622737
TCC: 18589817
GRA: 105799411
GAB: 108456712
DZI: 111301841
VRA: 106759191
VAR: 108333356
VUN: 114185523
CAM: 101495267
LJA: Lj3g3v1694660.1(Lj3g3v1694660.1)
ADU: 107461425
LANG: 109351322
FVE: 101298861
RCN: 112202499
PPER: 18780893
PMUM: 103326686
PAVI: 110760280
PXB: 103965536
ZJU: 107412613
CSV: 101211977
CMO: 103492036
MCHA: 111021441
CMAX: 111485375
CMOS: 111461442
CPEP: 111779652
RCU: 8274436
JCU: 105648267
MESC: 110617223
POP: 7467360
PEU: 105126367
JRE: 109003655
VVI: 100248547
SOT: 102596284
CANN: 107853580
NSY: 104224061
NTO: 104111014
NAU: 109241093
INI: 109160132
SIND: 105163571
OEU: 111404472
HAN: 110866903
CCAV: 112511831
DCR: 108226793
BVG: 104889971
SOE: 110801608
NNU: 104603426
OSA: 4333171
DOSA: Os03t0429800-01(Os03g0429800)
OBR: 102707013
BDI: 100827961
ATS: 109737702(LOC109737702) 109742032(LOC109742032)
SBI: 110434890
ZMA: 100384368
SITA: 101785503
PDA: 103715913
EGU: 105056188
MUS: 103989027
DCT: 110115026
PEQ: 110018507
CRE: CHLREDRAFT_117669(XDH1)
APRO: F751_6411
SLB: AWJ20_3928(AOH2)
NCR: NCU03350(xdh-1)
NTE: NEUTE1DRAFT130703(NEUTE1DRAFT_130703)
MGR: MGG_12738
SSCK: SPSK_00201
MAW: MAC_05768
MAJ: MAA_01730
CMT: CCM_08980
MBE: MBM_00517
ANG: ANI_1_1056034(An03g01530) ANI_1_902184(An04g05440)
ABE: ARB_02280
TVE: TRV_04973
DDI: DDB_G0291047(xdh)
DFA: DFA_00340(xdh)
ARA: Arad_9877
SACI: Sinac_0251
FJG: BB050_03475(xdhA_2)
 » show all
Reference
PMID:8224915
  Authors
Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T
  Title
Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene.
  Journal
Gene 133:279-84 (1993)
DOI:10.1016/0378-1119(93)90652-J
  Sequence
[hsa:7498]
Reference
  Authors
Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T
  Title
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase.
  Journal
FEBS J 275:3278-89 (2008)
DOI:10.1111/j.1742-4658.2008.06489.x
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