KEGG   ORTHOLOGY: K00129
Entry
K00129                      KO                                     

Name
ALDH3
Definition
aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00340  Histidine metabolism
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00410  beta-Alanine metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
  09105 Amino acid metabolism
   00340 Histidine metabolism
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
   00350 Tyrosine metabolism
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
   00360 Phenylalanine metabolism
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
   00982 Drug metabolism - cytochrome P450
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.5  aldehyde dehydrogenase [NAD(P)+]
     K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+)
Other DBs
RN: R00711 R00904 R02536 R02537 R02695 R02697 R03300 R03302 R04882 R04883 R04888 R04889 R04891 R04892 R04996 R07104 R08282 R08283 R08307
COG: COG1012
GO: 0004030
Genes
HSA: 218(ALDH3A1) 221(ALDH3B1) 222(ALDH3B2)
PTR: 466685(ALDH3B2) 468186(ALDH3A1) 747335(ALDH3B1)
PPS: 100970713(ALDH3A1) 100992841(ALDH3B2) 100993681(ALDH3B1)
GGO: 101131216(ALDH3A1) 101144902 101147407(ALDH3B1)
PON: 100446485(ALDH3A1) 100450634(ALDH3B1) 100453112(ALDH3B2)
NLE: 100582304 100582987 100585710(ALDH3A1)
MCC: 703870(ALDH3A1) 710746(ALDH3B1) 721683(ALDH3B2)
MCF: 102120140(ALDH3B1) 102122172(ALDH3B2) 102140050(ALDH3A1)
CSAB: 103216001(ALDH3B1) 103216342(ALDH3B2) 103242519(ALDH3A1)
RRO: 104663273(ALDH3A1) 104664720(ALDH3B1) 104664722(ALDH3B2)
RBB: 108518605 108518676(ALDH3B1) 108521944(ALDH3A1)
CJC: 100385438(ALDH3A1) 100399356 100405175(ALDH3B1)
SBQ: 101028257(ALDH3B2) 101053003(ALDH3A1) 101054144(ALDH3B1)
MMU: 11670(Aldh3a1) 621603(Aldh3b2) 67689(Aldh3b1) 73458(Aldh3b3)
MCAL: 110285533 110285705 110305274(Aldh3a1)
MPAH: 110325520 110327470 110331990(Aldh3a1)
RNO: 25375(Aldh3a1) 309147(Aldh3b1) 688778 688800(Aldh3b2)
MUN: 110539491(Aldh3a1) 110547135(Aldh3b1) 110547153(Aldh3b2)
NGI: 103724848(Aldh3a1) 103744514(Aldh3b1) 103749592
HGL: 101699453(Aldh3a1) 101722793(Aldh3b1) 101724442(Aldh3b2)
CCAN: 109688192(Aldh3a1) 109692072 109692074(Aldh3b1)
OCU: 103346087(ALDH3B1)
TUP: 102474716(ALDH3B1) 102475132 102490907(ALDH3A1)
CFA: 476003(ALDH3B1) 489526(ALDH3A1) 611806
VVP: 112924171 112924936(ALDH3A1)
AML: 100467493(ALDH3B2) 100467748(ALDH3B1) 100482437(ALDH3A1)
UMR: 103658510(ALDH3A1) 103679525 103679621(ALDH3B1)
ORO: 101364411(ALDH3A1) 101376873(ALDH3B1) 101377457
FCA: 101094208(ALDH3B1) 101096364(ALDH3A1) 105259663
PTG: 102953099(ALDH3A1) 102964294(ALDH3B2) 102969525(ALDH3B1)
PPAD: 109245805(ALDH3A1) 109246870 109246871(ALDH3B1)
AJU: 106971094(ALDH3B1) 106971159 106981410(ALDH3A1)
BTA: 281617(ALDH3A1) 508879 511469(ALDH3B1)
BIU: 109554323(ALDH3B1) 109554325 109573432(ALDH3A1)
BBUB: 102395921 102396234(ALDH3B1) 102398004(ALDH3A1)
CHX: 102179701(ALDH3A1) 102185156 102185988(ALDH3B1)
OAS: 101108502(ALDH3A1) 101111922 101112687(ALDH3B1)
SSC: 100522421 100526075(ALDH3A1) 100739347(ALDH3B1)
CFR: 102508421 102521023(ALDH3B1)
CDK: 105085091(ALDH3A1) 105104409(ALDH3B1) 105104411
BACU: 103000712(ALDH3A1) 103004940(ALDH3B1)
LVE: 103068962(ALDH3B1) 103078726(ALDH3B2) 103083340(ALDH3A1)
OOR: 101271204(ALDH3B2) 101273844(ALDH3A1) 101290322(ALDH3B1)
DLE: 111167761(ALDH3A1) 111183652(ALDH3B1) 111183655(ALDH3B2)
PCAD: 102989528(ALDH3A1) 102995351(ALDH3B1)
ECB: 100053296 100053339(ALDH3B1) 100073157(ALDH3A1)
EAI: 106833481(ALDH3B2) 106838852(ALDH3A1) 106844279(ALDH3B1)
MYB: 102255064 102255772(ALDH3B1) 102260012(ALDH3A1)
MYD: 102761807(ALDH3B1) 102762385(ALDH3B2) 102774766(ALDH3A1)
MNA: 107524558(ALDH3A1) 107537419 107537442(ALDH3B1)
PALE: 102888323(ALDH3B2) 102889891(ALDH3A1) 102895234(ALDH3B1)
RAY: 107503495(ALDH3B1) 107503541 107511050(ALDH3A1)
MJV: 108383525(ALDH1A3) 108387572 108405835(ALDH3B1)
MDO: 100010416(ALDH3B1) 100020100 100020131(ALDH3A1)
SHR: 100932557(ALDH3B1) 100933346 100934715(ALDH3A1)
GGA: 428812(ALDH3B1L1) 428813(ALDH3B1L2)
ACYG: 106048259(ALDH3B1) 106048260
TGU: 100232483
LSR: 110485004
GFR: 102032126 102032291(ALDH3B1)
FAB: 101809399 101809598(ALDH3B1)
PHI: 102103263 102103447(ALDH3B1)
CCW: 104692991(ALDH3B1)
FPG: 101919850(ALDH3B1) 101920028
CLV: 102096341(ALDH3B1)
NNI: 104009022 104020535(ALDH3B1)
PADL: 103923776
CMY: 102931111 102936985(ALDH3B1)
CPIC: 101932058(ALDH3B1) 101937286
PVT: 110085672(ALDH3B1)
TSR: 106538896 106538897(ALDH3B1)
PMUA: 114602234(ALDH3B1)
XLA: 108711844 447062(aldh3b1.L)
XTR: 100145787(aldh3b2) 548883(aldh3b1)
DRE: 282559(aldh3b1) 557008(aldh3b2)
SRX: 107724427
SANH: 107698763
SGH: 107601228
IPU: 108258475(ALDH3B1)
PHYP: 113528369
AMEX: 103038420
EEE: 113574356
LCO: 104921301 104935243(aldh3b1)
OLA: 101157544 101158531(aldh3b1)
XMA: 102225391(aldh3b1) 102230203
XCO: 114147611(aldh3b1) 114154452
PRET: 103468182(aldh3b1) 103470338
CVG: 107097252 107104032(aldh3b1)
HCQ: 109511573
BPEC: 110162488
ELS: 105030765(aldh3b1)
SFM: 108925968(aldh3b1) 108932607
LCM: 102361849(ALDH3B1)
CMK: 103173942
DME: Dmel_CG11140(Aldh-III)
DSI: Dsimw501_GD10252(Dsim_GD10252)
DAZ: 108616863
TCA: 107398462
BMOR: 101735899
BMAN: 114239410
TUT: 107360456
EGL: EGR_03672
MAW: MAC_00416
DDI: DDB_G0292270(comG)
DFA: DFA_09276(comG)
ROP: ROP_14250
RHB: NY08_3164
 » show all
Reference
PMID:1737758
  Authors
Hsu LC, Chang WC, Shibuya A, Yoshida A
  Title
Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli.
  Journal
J Biol Chem 267:3030-7 (1992)
  Sequence
[hsa:218]
Reference
  Authors
Marchitti SA, Orlicky DJ, Vasiliou V
  Title
Expression and initial characterization of human ALDH3B1.
  Journal
Biochem Biophys Res Commun 356:792-8 (2007)
DOI:10.1016/j.bbrc.2007.03.046
  Sequence
[hsa:221]
Reference
PMID:9490025
  Authors
Yoshida A, Rzhetsky A, Hsu LC, Chang C
  Title
Human aldehyde dehydrogenase gene family.
  Journal
Eur J Biochem 251:549-57 (1998)
DOI:10.1046/j.1432-1327.1998.2510549.x
LinkDB

KEGG   ENZYME: 1.2.1.5
Entry
EC 1.2.1.5                  Enzyme                                 

Name
aldehyde dehydrogenase [NAD(P)+];
ALDH
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
aldehyde:NAD(P)+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+ [RN:R00538 R00634]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.5 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00340  Histidine metabolism
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00410  beta-Alanine metabolism
ec00980  Metabolism of xenobiotics by cytochrome P450
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+)
Genes
HSA: 218(ALDH3A1) 221(ALDH3B1) 222(ALDH3B2)
PTR: 466685(ALDH3B2) 468186(ALDH3A1) 747335(ALDH3B1)
PPS: 100970713(ALDH3A1) 100992841(ALDH3B2) 100993681(ALDH3B1)
GGO: 101131216(ALDH3A1) 101144902 101147407(ALDH3B1)
PON: 100446485(ALDH3A1) 100450634(ALDH3B1) 100453112(ALDH3B2)
NLE: 100582304 100582987 100585710(ALDH3A1)
MCC: 703870(ALDH3A1) 710746(ALDH3B1) 721683(ALDH3B2)
MCF: 102120140(ALDH3B1) 102122172(ALDH3B2) 102140050(ALDH3A1)
CSAB: 103216001(ALDH3B1) 103216342(ALDH3B2) 103242519(ALDH3A1)
RRO: 104663273(ALDH3A1) 104664720(ALDH3B1) 104664722(ALDH3B2)
RBB: 108518605 108518676(ALDH3B1) 108521944(ALDH3A1)
CJC: 100385438(ALDH3A1) 100399356 100405175(ALDH3B1)
SBQ: 101028257(ALDH3B2) 101053003(ALDH3A1) 101054144(ALDH3B1)
MMU: 11670(Aldh3a1) 621603(Aldh3b2) 67689(Aldh3b1) 73458(Aldh3b3)
MCAL: 110285533 110285705 110305274(Aldh3a1)
MPAH: 110325520 110327470 110331990(Aldh3a1)
RNO: 25375(Aldh3a1) 309147(Aldh3b1) 688778 688800(Aldh3b2)
MUN: 110539491(Aldh3a1) 110547135(Aldh3b1) 110547153(Aldh3b2)
NGI: 103724848(Aldh3a1) 103744514(Aldh3b1) 103749592
HGL: 101699453(Aldh3a1) 101722793(Aldh3b1) 101724442(Aldh3b2)
CCAN: 109688192(Aldh3a1) 109692072 109692074(Aldh3b1)
OCU: 103346087(ALDH3B1)
TUP: 102474716(ALDH3B1) 102475132 102490907(ALDH3A1)
CFA: 476003(ALDH3B1) 489526(ALDH3A1) 611806
VVP: 112924171 112924936(ALDH3A1)
AML: 100467493(ALDH3B2) 100467748(ALDH3B1) 100482437(ALDH3A1)
UMR: 103658510(ALDH3A1) 103679525 103679621(ALDH3B1)
ORO: 101364411(ALDH3A1) 101376873(ALDH3B1) 101377457
FCA: 101094208(ALDH3B1) 101096364(ALDH3A1) 105259663
PTG: 102953099(ALDH3A1) 102964294(ALDH3B2) 102969525(ALDH3B1)
PPAD: 109245805(ALDH3A1) 109246870 109246871(ALDH3B1)
AJU: 106971094(ALDH3B1) 106971159 106981410(ALDH3A1)
BTA: 281617(ALDH3A1) 508879 511469(ALDH3B1)
BIU: 109554323(ALDH3B1) 109554325 109573432(ALDH3A1)
BBUB: 102395921 102396234(ALDH3B1) 102398004(ALDH3A1)
CHX: 102179701(ALDH3A1) 102185156 102185988(ALDH3B1)
OAS: 101108502(ALDH3A1) 101111922 101112687(ALDH3B1)
SSC: 100522421 100526075(ALDH3A1) 100739347(ALDH3B1)
CFR: 102508421 102521023(ALDH3B1)
CDK: 105085091(ALDH3A1) 105104409(ALDH3B1) 105104411
BACU: 103000712(ALDH3A1) 103004940(ALDH3B1)
LVE: 103068962(ALDH3B1) 103078726(ALDH3B2) 103083340(ALDH3A1)
OOR: 101271204(ALDH3B2) 101273844(ALDH3A1) 101290322(ALDH3B1)
DLE: 111167761(ALDH3A1) 111183652(ALDH3B1) 111183655(ALDH3B2)
PCAD: 102989528(ALDH3A1) 102995351(ALDH3B1)
ECB: 100053296 100053339(ALDH3B1) 100073157(ALDH3A1)
EAI: 106833481(ALDH3B2) 106838852(ALDH3A1) 106844279(ALDH3B1)
MYB: 102255064 102255772(ALDH3B1) 102260012(ALDH3A1)
MYD: 102761807(ALDH3B1) 102762385(ALDH3B2) 102774766(ALDH3A1)
MNA: 107524558(ALDH3A1) 107537419 107537442(ALDH3B1)
PALE: 102888323(ALDH3B2) 102889891(ALDH3A1) 102895234(ALDH3B1)
RAY: 107503495(ALDH3B1) 107503541 107511050(ALDH3A1)
MJV: 108383525(ALDH1A3) 108387572 108405835(ALDH3B1)
MDO: 100010416(ALDH3B1) 100020100 100020131(ALDH3A1)
SHR: 100932557(ALDH3B1) 100933346 100934715(ALDH3A1)
GGA: 428812(ALDH3B1L1) 428813(ALDH3B1L2)
ACYG: 106048259(ALDH3B1) 106048260
TGU: 100232483
LSR: 110485004
GFR: 102032126 102032291(ALDH3B1)
FAB: 101809399 101809598(ALDH3B1)
PHI: 102103263 102103447(ALDH3B1)
CCW: 104692991(ALDH3B1)
FPG: 101919850(ALDH3B1) 101920028
CLV: 102096341(ALDH3B1)
NNI: 104009022 104020535(ALDH3B1)
PADL: 103923776
CMY: 102931111 102936985(ALDH3B1)
CPIC: 101932058(ALDH3B1) 101937286
PVT: 110085672(ALDH3B1)
TSR: 106538896 106538897(ALDH3B1)
PMUA: 114602234(ALDH3B1)
XLA: 108711844 447062(aldh3b1.L)
XTR: 100145787(aldh3b2) 548883(aldh3b1)
DRE: 282559(aldh3b1) 557008(aldh3b2)
SRX: 107724427
SANH: 107698763
SGH: 107601228
IPU: 108258475(ALDH3B1)
PHYP: 113528369
AMEX: 103038420
EEE: 113574356
LCO: 104921301 104935243(aldh3b1)
OLA: 101157544 101158531(aldh3b1)
XMA: 102225391(aldh3b1) 102230203
XCO: 114147611(aldh3b1) 114154452
PRET: 103468182(aldh3b1) 103470338
CVG: 107097252 107104032(aldh3b1)
HCQ: 109511573
BPEC: 110162488
ELS: 105030765(aldh3b1)
SFM: 108925968(aldh3b1) 108932607
LCM: 102361849(ALDH3B1)
CMK: 103173942
DME: Dmel_CG11140(Aldh-III)
DSI: Dsimw501_GD10252(Dsim_GD10252)
DAZ: 108616863
TCA: 107398462
BMOR: 101735899
BMAN: 114239410
TUT: 107360456
EGL: EGR_03672
MAW: MAC_00416
DDI: DDB_G0292270(comG)
DFA: DFA_09276(comG)
ROP: ROP_14250
RHB: NY08_3164
 » show all
Reference
1  [PMID:14904038]
  Authors
BLACK S.
  Title
Yeast aldehyde dehydrogenase.
  Journal
Arch Biochem 34:86-97 (1951)
DOI:10.1016/S0003-9861(51)80013-4
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3  [PMID:13319337]
  Authors
KING TE, CHELDELIN VH.
  Title
Oxidation of acetaldehyde by Acetobacter suboxydans.
  Journal
J Biol Chem 220:177-91 (1956)
Reference
4  [PMID:4293780]
  Authors
Steinman CR, Jakoby WB.
  Title
Yeast aldehyde dehydrogenase. I. Purification and crystallization.
  Journal
J Biol Chem 242:5019-23 (1967)
Reference
5  [PMID:13363916]
  Authors
TANENBAUM SW.
  Title
The metabolism of Acetobacter peroxidans.  I.  Oxidative enzymes.
  Journal
Biochim Biophys Acta 21:335-42 (1956)
DOI:10.1016/0006-3002(56)90017-8
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.5
IUBMB Enzyme Nomenclature: 1.2.1.5
ExPASy - ENZYME nomenclature database: 1.2.1.5
BRENDA, the Enzyme Database: 1.2.1.5
CAS: 9028-88-0
LinkDB

KEGG   REACTION: R03300
Entry
R03300                      Reaction                               

Name
3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
Definition
3,4-Dihydroxyphenylacetaldehyde + NAD+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADH + H+
Equation
Comment
NADP+ (see R03302)
Reaction class
RC00001  C00003_C00004
RC00080  C01161_C04043
Enzyme
1.2.1.5         1.2.1.29
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
LinkDB

KEGG   REACTION: R03302
Entry
R03302                      Reaction                               

Name
3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
Definition
3,4-Dihydroxyphenylacetaldehyde + NADP+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADPH + H+
Equation
Comment
NAD+ (see R03300)
Reaction class
RC00001  C00005_C00006
RC00080  C01161_C04043
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
LinkDB

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