KEGG   ORTHOLOGY: K00152
Entry
K00152                      KO                                     

Name
nahF
Definition
salicylaldehyde dehydrogenase [EC:1.2.1.65]
Pathway
ko00626  Naphthalene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K00152  nahF; salicylaldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.65  salicylaldehyde dehydrogenase
     K00152  nahF; salicylaldehyde dehydrogenase
Other DBs
RN: R02941
GO: 0018485
Genes
PPI: ND058(nahF)
PSC: A458_06710
PSTU: UIB01_22640
PBM: CL52_14625
PFK: PFAS1_28625
RMN: TK49_07965
BMK: DM80_1446
PARB: CJU94_38645
PNA: Pnap_2482
AG: BAE92159(nahF)
Reference
  Authors
Sota M, Yano H, Ono A, Miyazaki R, Ishii H, Genka H, Top EM, Tsuda M
  Title
Genomic and functional analysis of the IncP-9 naphthalene-catabolic plasmid NAH7 and its transposon Tn4655 suggests catabolic gene spread by a tyrosine recombinase.
  Journal
J Bacteriol 188:4057-67 (2006)
DOI:10.1128/JB.00185-06
  Sequence
LinkDB

KEGG   ENZYME: 1.2.1.65
Entry
EC 1.2.1.65                 Enzyme                                 

Name
salicylaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
salicylaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+ [RN:R02941]
Reaction(KEGG)
R02941
Substrate
salicylaldehyde [CPD:C06202];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the naphthalene degradation pathway in some bacteria.
History
EC 1.2.1.65 created 2000, modified 2011
Pathway
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00152  salicylaldehyde dehydrogenase
Genes
PPI: ND058(nahF)
PSC: A458_06710
PSTU: UIB01_22640
PBM: CL52_14625
PFK: PFAS1_28625
RMN: TK49_07965
BMK: DM80_1446
PARB: CJU94_38645
PNA: Pnap_2482
Reference
1  [PMID:1447127]
  Authors
Eaton RW, Chapman PJ.
  Title
Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions.
  Journal
J Bacteriol 174:7542-54 (1992)
DOI:10.1128/JB.174.23.7542-7554.1992
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.65
IUBMB Enzyme Nomenclature: 1.2.1.65
ExPASy - ENZYME nomenclature database: 1.2.1.65
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.65
BRENDA, the Enzyme Database: 1.2.1.65
CAS: 55354-34-2
LinkDB

KEGG   REACTION: R02941
Entry
R02941                      Reaction                               

Name
salicylaldehyde:NAD+ oxidoreductase
Definition
Salicylaldehyde + NAD+ + H2O <=> Salicylate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00075  C00805_C06202
Enzyme
1.2.1.65        1.2.1.-
Pathway
rn00626  Naphthalene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Orthology
K00152  salicylaldehyde dehydrogenase [EC:1.2.1.65]
Other DBs
RHEA: 18540
LinkDB

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