Entry |
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Name |
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Definition |
pyruvate dehydrogenase E1 component alpha subunit [EC: 1.2.4.1]
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Pathway |
ko00010 | Glycolysis / Gluconeogenesis |
ko01110 | Biosynthesis of secondary metabolites |
ko01120 | Microbial metabolism in diverse environments |
ko05230 | Central carbon metabolism in cancer |
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Module |
M00307 | Pyruvate oxidation, pyruvate => acetyl-CoA |
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Disease |
H00072 | Pyruvate dehydrogenase complex deficiency |
H01997 | Pyruvate dehydrogenase E1-alpha deficiency |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
00020 Citrate cycle (TCA cycle)
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
00620 Pyruvate metabolism
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
Enzymes [BR:ko01000]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Fries M, Jung HI, Perham RN |
Title |
Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes. |
Journal |
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Reference |
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Authors |
Kato M, Wynn RM, Chuang JL, Tso SC, Machius M, Li J, Chuang DT |
Title |
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. |
Journal |
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Sequence |
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Reference |
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Authors |
Ho L, Wexler ID, Liu TC, Thekkumkara TJ, Patel MS |
Title |
Characterization of cDNAs encoding human pyruvate dehydrogenase alpha subunit. |
Journal |
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Sequence |
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LinkDB |
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