KEGG   ORTHOLOGY: K00290Help
Entry
K00290                      KO                                     

Name
LYS1
Definition
saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
Pathway
ko00300  Lysine biosynthesis
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming)
   00310 Lysine degradation
    K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.7  saccharopine dehydrogenase (NAD+, L-lysine-forming)
     K00290  LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming)
BRITE hierarchy
Other DBs
RN: R00715
GO: 0004754
Genes
NVE: NEMVE_v1g165768
EPA: 110253051
ADF: 107350380
PDAM: 113665962 113665974 113665975
SPIS: 111333439 111333523 111335282 111337694
QSU: 111987599 112002453
SCE: YIR034C(LYS1)
AGO: AGOS_ACR167C
ERC: Ecym_5636
KLA: KLLA0_E07987g
KMX: KLMA_40368(LYS1)
NCS: NCAS_0A08650(NCAS0A08650)
NDI: NDAI_0G05090(NDAI0G05090)
TPF: TPHA_0N01860(TPHA0N01860)
TBL: TBLA_0C01000(TBLA0C01000)
TDL: TDEL_0B07590(TDEL0B07590)
KAF: KAFR_0A00160(KAFR0A00160)
PIC: PICST_86170(LYS1)
SPAA: SPAPADRAFT_147229(LYS1)
CAL: CAALFM_C405320WA(LYS1)
SLB: AWJ20_1568(LYS1)
NCR: NCU03118
NTE: NEUTE1DRAFT91293(NEUTE1DRAFT_91293)
MGR: MGG_01359
SSCK: SPSK_03427
MAW: MAC_09690
MAJ: MAA_06003
BFU: BCIN_05g04270(Bclys1)
MBE: MBM_03432
ANG: ANI_1_1044024(An02g07500)
ABE: ARB_05726
TVE: TRV_03009
PTE: PTT_12058
SPO: SPAC227.18(lys3)
CNE: CND06290
CNB: CNBD0140
MRR: Moror_145
ABP: AGABI1DRAFT96692(AGABI1DRAFT_96692)
ABV: AGABI2DRAFT133180(AGABI2DRAFT_133180)
MGL: MGL_0554
PPR: PBPRB1102(SAV1788)
SVO: SVI_3927
SPSW: Sps_03208
ILO: IL1999
PAT: Patl_0748
AMAL: I607_14825
AMAE: I876_15125
AMAO: I634_15070
AMAD: I636_14935
AMAI: I635_15510
AMAG: I533_14650
AMAC: MASE_14680
AAUS: EP12_15405
ASP: AOR13_357
GNI: GNIT_2771
GPS: C427_0697
SALH: HMF8227_02643(lys1)
CJA: CJA_1512
SDE: Sde_1597
TTU: TERTU_1609(lys1)
FTN: FTN_0964
MEJ: Q7A_1601
MEC: Q7C_158
GPB: HDN1F_21040(LYS1)
BPL: BURPS1106A_2136(lys1)
BAM: Bamb_1645
BXE: Bxe_A1992
HPY: HP1507
HPJ: jhp_1400
HPL: HPB8_22(lys1)
HPO: HMPREF4655_20104(LYS1)
HPZ: HPKB_1410
HPX: HMPREF0462_1493(LYS1)
HPD: KHP_1359
HEY: MWE_1695
HPYR: K747_03640
HPYI: K750_01025
HPYU: K751_00220
HPYM: K749_06405
HEB: U063_1528
HEZ: U064_1532
HHE: HH_1098
HAC: Hac_0077(lys1)
HMS: HMU04660
HCE: HCW_01395
HCM: HCD_04495
HCP: HCN_0065
WSU: WS0167
SUA: Saut_1041
SULR: B649_05735
CJE: Cj0172c
CJU: C8J_0166
CJI: CJSA_0162
CJM: CJM1_0172(lys1)
CJS: CJS3_0168
CJEJ: N564_00164
CJEU: N565_00160
CJEN: N755_00216
CJEI: N135_00226
CJER: H730_01180
CJQ: UC78_0172
CJR: CJE0165
CFF: CFF8240_0285(lys)
CFZ: CSG_3660
CHA: CHAB381_0061(lys1)
CLA: CLA_0458
CCQ: N149_1538
CCF: YSQ_09040
CCY: YSS_08785
CCOI: YSU_08025
CCOF: VC76_07875
CIS: CINS_0435
CVO: CVOL_0449
CPEL: CPEL_0468
CGRA: CGRAC_1895
CURE: CUREO_1210
CHYO: CHH_0278
CSPF: CSF_1450
CCUN: CCUN_1762
CLX: CLAN_0255
CAVI: CAV_1442
CAMY: CSUIS_0351
ABU: Abu_1706
ABT: ABED_1560
AMYT: AMYT_2132
ARC: ABLL_2163
SDL: Sdel_2142
SMUL: SMUL_2982
SHAL: SHALO_2761
SULJ: SJPD1_2652
HYO: NNO_1018
NIS: NIS_1295
SUN: SUN_1368
NAM: NAMH_0224(lys)
GSU: GSU2539
GME: Gmet_0902
GUR: Gura_0981
GLO: Glov_1676
GBM: Gbem_2918
GEO: Geob_1676
GEM: GM21_1307
GEB: GM18_2804
PCA: Pcar_2095
PPD: Ppro_2607
DEU: DBW_2867
DVU: DVU0418(lys1)
DVL: Dvul_2516
DVM: DvMF_1535
DDE: Dde_0572
DDS: Ddes_0125
DTR: RSDT_0639
DFL: DFE_2478
DAS: Daes_0893
DPI: BN4_10684
DBA: Dbac_2320
DSF: UWK_00577
DAL: Dalk_4658
DAT: HRM2_01410(lysA1)
DTO: TOL2_C01090(lys1)
HOH: Hoch_6504
SFU: Sfum_1922
RLE: RL0376
BBK: BARBAKC583_0028(lys1)
HDN: Hden_1144
CAK: Caul_4440
SIL: SPO0601 SPO3307(lkr)
RSP: RSP_1086(sdh)
JAN: Jann_4015
RDE: RD1_0698
PDE: Pden_2709
PSF: PSE_3136
PGD: Gal_03330
OTM: OSB_29950(ald_3)
MALG: MALG_00109
RMM: ROSMUCSMR3_00818(ald)
HNE: HNE_0588(lys1)
HBA: Hbal_0824
NAR: Saro_1790
SAL: Sala_1201
SPHP: LH20_11605
SMAZ: LH19_07835
SGI: SGRAN_1982(lys1.2)
SPHU: SPPYR_1863
SSY: SLG_24390
SPMI: K663_07865
SPHB: EP837_00148(lys1)
SPHR: BSY17_225
SINB: SIDU_05720
SPHT: K426_13345
BLAS: BSY18_983
ELI: ELI_04720
AAY: WYH_00754
ALB: AEB_P1964
MGM: Mmc1_1081
BHA: BH3957
BAG: Bcoa_1339
BCOA: BF29_2204
BACO: OXB_3524
LSP: Bsph_3480
PPY: PPE_01639
PPM: PPSC2_08685(lyS2)
PPO: PPM_1652(lyS2)
PPOL: X809_08940
PPOY: RE92_03620
PSAB: PSAB_09355
PRI: PRIO_2443
SIV: SSIL_1363
SPN: SP_0919
SPD: SPD_0812(lys1)
SPR: spr0820
SPW: SPCG_0896
SJJ: SPJ_0860(lys)
SPX: SPG_0845
SNT: SPT_1280(lys)
SND: MYY_1280
SPNN: T308_05995
SPV: SPH_1028(lys)
SNC: HMPREF0837_11566(LYS1)
SNM: SP70585_0958(lys)
SPP: SPP_0927(lys)
SNB: SP670_1400(lys)
SNP: SPAP_0951
SSUT: TL13_1239
SUB: SUB1319
SOR: SOR_1016
STRN: SNAG_1016
CBK: CLL_A1014
CBT: CLH_0948
CBE: Cbei_4409
CBZ: Cbs_4409
CBEI: LF65_04944
CLO: HMPREF0868_0009(LYS1)
CCE: Ccel_1128
CSD: Clst_1728
CCEL: CCDG5_1249
RCH: RUM_16860
RUM: CK1_02290
FPR: FP2_18080
FPA: FPR_20600
BPB: bpr_I1198
BFI: CIY_29960
BHU: bhn_I1115
RIX: RO1_05620
RIM: ROI_13440
CCT: CC1_03140
ROB: CK5_14020
RTO: RTO_08360
CPY: Cphy_3052
CSO: CLS_12090
HSD: SD1D_1343
CPRO: CPRO_20210
ERT: EUR_04860
ERA: ERE_14650
DSY: DSY3821
DHD: Dhaf_1555
SGY: Sgly_3179
AWO: Awo_c05360(sdh)
OVA: OBV_12680
BPRM: CL3_09040
BPRS: CK3_17620
MHG: MHY_16130
MAV: MAV_1723
SHY: SHJG_7558
SERJ: SGUI_2172
SEN: SACE_1566(lys1)
AMI: Amir_3541
SAQ: Sare_1048
SYN: slr0049
SYY: SYNGTS_2301(slr0049)
SYT: SYNGTI_2300(slr0049)
SYS: SYNPCCN_2299(slr0049)
SYQ: SYNPCCP_2299(slr0049)
DRA: DR_1252
DGE: Dgeo_0999
DFC: DFI_04480
CAA: Caka_0667
AMU: Amuc_0148
AGL: PYTT_2014
LBA: Lebu_0786
FSC: FSU_0920
BTH: BT_4612
BFR: BF1215
BVU: BVU_2379
BXY: BXY_37200
PGI: PG_0677(LYS1)
PGN: PGN_0713
PGT: PGTDC60_1802(lys1)
PDI: BDI_1450
TFO: BFO_2571
PSAC: PSM36_2037
APS: CFPG_304
PRU: PRU_0067(lys1)
PMZ: HMPREF0659_A5557(LYS1)
PDN: HMPREF9137_1758(LYS1)
AFD: Alfi_3014
ASH: AL1_04530
DORI: FH5T_01740
SRU: SRU_1725(lys1)
CHU: CHU_2707(lys)
DFE: Dfer_2888
SLI: Slin_3519
LBY: Lbys_1539
FAE: FAES_2748
PSEZ: HME7025_01355(lys1)
MPI: Mpet_0844
VMO: VMUT_1174
 » show all
TaxonomyKoalaUniProt
Reference
PMID:4287986
  Authors
Saunders PP, Broquist HP
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
  Journal
J Biol Chem 241:3435-40 (1966)
  Sequence
[sce:YIR034C]
LinkDB All DBs

KEGG   REACTION: R00715Help
Entry
R00715                      Reaction                               

Name
N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Definition
N6-(L-1,3-Dicarboxypropyl)-L-lysine + NAD+ + H2O <=> L-Lysine + 2-Oxoglutarate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00217  C00047_C00449
RC01532  C00026_C00449
Enzyme
Pathway
rn00300  Lysine biosynthesis
rn00310  Lysine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Orthology
K00290  saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
Other DBs
RHEA: 12443
LinkDB All DBs

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