KEGG   ORTHOLOGY: K00293
Entry
K00293                      KO                                     

Name
LYS9
Definition
saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
Pathway
ko00300  Lysine biosynthesis
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming)
   00310 Lysine degradation
    K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.10  saccharopine dehydrogenase (NADP+, L-glutamate-forming)
     K00293  LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming)
Other DBs
RN: R02315
COG: COG1748
GO: 0004755
Genes
NVE: 116616792
QSU: 111989186 112001276
SCE: YNR050C(LYS9)
AGO: AGOS_ABR116C
ERC: Ecym_7008
KLA: KLLA0_C18744g
KMX: KLMA_40016(LYS9)
LTH: KLTH0A07590g
VPO: Kpol_1028p12
ZRO: ZYRO0D17578g
NCS: NCAS_0A05670(NCAS0A05670)
NDI: NDAI_0K02690(NDAI0K02690)
TPF: TPHA_0M02120(TPHA0M02120)
TBL: TBLA_0F00190(TBLA0F00190)
TDL: TDEL_0A07910(TDEL0A07910)
KAF: KAFR_0C04810(KAFR0C04810)
PIC: PICST_70210(LYS9)
CAL: CAALFM_C306590WA(LYS9)
NCR: NCU03748
NTE: NEUTE1DRAFT58317(NEUTE1DRAFT_58317)
MGR: MGG_17041
SSCK: SPSK_03190
MAW: MAC_01390
MAJ: MAA_08309
CMT: CCM_00396
BFU: BCIN_03g09280(Bclys9)
MBE: MBM_03741
ANI: AN5601.2
ANG: ANI_1_3268014(An01g13590) ANI_1_878184(An04g05260)
PCS: Pc22g05800(Lys7)
ABE: ARB_02329
TVE: TRV_04693
PTE: PTT_10655
ZTR: MYCGRDRAFT_110462(LYS9)
DDI: DDB_G0285267(sdh)
KKO: Kkor_1620
 » show all
Reference
PMID:7935367
  Authors
Feller A, Dubois E, Ramos F, Pierard A
  Title
Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation.
  Journal
Mol Cell Biol 14:6411-8 (1994)
DOI:10.1128/mcb.14.10.6411
  Sequence
[sce:YNR050C]
Reference
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
DOI:10.1039/A801345D
LinkDB

KEGG   ORTHOLOGY: K24034
Entry
K24034                      KO                                     

Name
SPE3-LYS9
Definition
spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10]
Pathway
ko00270  Cysteine and methionine metabolism
ko00300  Lysine biosynthesis
ko00310  Lysine degradation
ko00330  Arginine and proline metabolism
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
   00300 Lysine biosynthesis
    K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
   00310 Lysine degradation
    K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
   00330 Arginine and proline metabolism
    K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.10  saccharopine dehydrogenase (NADP+, L-glutamate-forming)
     K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.16  spermidine synthase
     K24034  SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Other DBs
RN: R01920 R02315 R08359
COG: COG0421 COG1748
GO: 0004766 0004755
Genes
CNE: CNG01150
CNB: CNBG3640
CGI: CGB_G5220C
TMS: TREMEDRAFT_74272
TASA: A1Q1_06672
TVS: TRAVEDRAFT_53623
DSQ: DICSQDRAFT_85486
PCO: PHACADRAFT_187523 PHACADRAFT_262714
SHS: STEHIDRAFT_76391
HIR: HETIRDRAFT_471805
ABP: AGABI1DRAFT64147(AGABI1DRAFT_64147)
ABV: AGABI2DRAFT184364(AGABI2DRAFT_184364)
MGL: MGL_1529
MRT: MRET_3829
 » show all
Reference
  Authors
Kingsbury JM, Yang Z, Ganous TM, Cox GM, McCusker JH
  Title
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
  Journal
Eukaryot Cell 3:752-63 (2004)
DOI:10.1128/EC.3.3.752-763.2004
  Sequence
[cne:CNG01150]
LinkDB

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