KEGG   ORTHOLOGY: K00295
Entry
K00295                      KO                                     

Name
MTD1
Definition
methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
Pathway
ko00670  One carbon pool by folate
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00295  MTD1; methylenetetrahydrofolate dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     K00295  MTD1; methylenetetrahydrofolate dehydrogenase (NAD+)
Other DBs
RN: R01218
COG: COG0190
GO: 0004487
Genes
FCD: 110848840
TUT: 107367341 107370758
QSU: 112021849 112023937
SCE: YKR080W(MTD1)
AGO: AGOS_ADR214W
ERC: Ecym_4047
KLA: KLLA0_A07953g
KMX: KLMA_10419(folD)
LTH: KLTH0F17754g
VPO: Kpol_489p12
NCS: NCAS_0A03350(NCAS0A03350)
NDI: NDAI_0A03210(NDAI0A03210)
TPF: TPHA_0H01380(TPHA0H01380)
TBL: TBLA_0A09280(TBLA0A09280)
TDL: TDEL_0B02500(TDEL0B02500)
KAF: KAFR_0H00370(KAFR0H00370)
CAL: CAALFM_C404720WA(CaO19.3810)
SLB: AWJ20_1683(MTD1)
NCR: NCU00963
NTE: NEUTE1DRAFT90232(NEUTE1DRAFT_90232)
MGR: MGG_10834
SSCK: SPSK_09467
MAW: MAC_03188
MAJ: MAA_04282
CMT: CCM_02303
BFU: BCIN_15g01620(Bcmtd1)
MBE: MBM_04386
ANI: AN1524.2
ANG: ANI_1_982144(An16g07400)
ABE: ARB_06549
TVE: TRV_04433
PTE: PTT_07593
CNE: CNF03710
CNB: CNBF1110
ABP: AGABI1DRAFT119972(AGABI1DRAFT_119972)
ABV: AGABI2DRAFT188587(AGABI2DRAFT_188587)
MGL: MGL_3825
MRT: MRET_0626
DDI: DDB_G0277725(thfA)
DFA: DFA_11465(thfA)
SMIN: v1.2.027029.t1(symbB.v1.2.027029.t1)
DEU: DBW_2270
 » show all
Reference
PMID:8416923
  Authors
West MG, Barlowe CK, Appling DR
  Title
Cloning and characterization of the Saccharomyces cerevisiae gene encoding NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase.
  Journal
J Biol Chem 268:153-60 (1993)
  Sequence
[sce:YKR080W]
LinkDB

KEGG   ORTHOLOGY: K13403
Entry
K13403                      KO                                     

Name
MTHFD2
Definition
methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Pathway
ko00670  One carbon pool by folate
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K13403  MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     K13403  MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     K13403  MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase
Other DBs
RN: R01218 R01655
GO: 0004487 0004477
Genes
HSA: 10797(MTHFD2) 441024(MTHFD2L)
PTR: 459331(MTHFD2) 461253(MTHFD2L)
PPS: 100974548(MTHFD2L) 100994215(MTHFD2)
GGO: 101139170(MTHFD2L) 101146472(MTHFD2)
PON: 100442117(MTHFD2) 100445055(MTHFD2L) 100456570
NLE: 100584729(MTHFD2) 100589055(MTHFD2L) 100590349
MCC: 702907(MTHFD2L) 714974(MTHFD2)
MCF: 102119606(MTHFD2L) 102144180(MTHFD2)
CSAB: 103220037(MTHFD2) 103235800(MTHFD2L)
RRO: 104658885(MTHFD2L) 104674805(MTHFD2)
RBB: 108515812(MTHFD2L) 108520674(MTHFD2) 108532678
CJC: 100389511(MTHFD2L) 100402525(MTHFD2)
SBQ: 101027806(MTHFD2) 101048869(MTHFD2L) 101052018
MMU: 17768(Mthfd2) 665563(Mthfd2l)
MCAL: 110294891(Mthfd2l) 110296265(Mthfd2)
MPAH: 110316109(Mthfd2) 110330651(Mthfd2l)
RNO: 305248(Mthfd2l) 680308(Mthfd2)
CGE: 100760811 100770086(Mthfd2)
NGI: 103727002(Mthfd2) 103742471(Mthfd2l)
HGL: 101703156(Mthfd2l) 101705997(Mthfd2)
CCAN: 109681115(Mthfd2l) 109688133(Mthfd2)
OCU: 100344170(MTHFD2L) 100349062(MTHFD2)
TUP: 102468110(MTHFD2L) 102477024(MTHFD2)
CFA: 482197(MTHFD2L) 483107(MTHFD2)
VVP: 112909247(MTHFD2L) 112916728(MTHFD2)
AML: 100463985(MTHFD2L) 100475974(MTHFD2)
UMR: 103665392(MTHFD2L) 103671402(MTHFD2)
UAH: 113243787(MTHFD2) 113263273(MTHFD2L)
ORO: 101365960(MTHFD2L) 101375555(MTHFD2)
FCA: 101083836(MTHFD2) 101093354(MTHFD2L)
PTG: 102961104(MTHFD2) 102967232(MTHFD2L)
PPAD: 109263019(MTHFD2) 109277695(MTHFD2L)
AJU: 106982039(MTHFD2L) 106988599(MTHFD2)
BTA: 517539(MTHFD2) 536269(MTHFD2L)
BOM: 102272253(MTHFD2L) 102277964(MTHFD2)
BIU: 109560580(MTHFD2L) 109565920(MTHFD2)
BBUB: 102390419(MTHFD2L) 102394714(MTHFD2)
CHX: 102179276 102184159(MTHFD2)
OAS: 100137069(MTHFD2) 101104908(MTHFD2L)
SSC: 100525706(MTHFD2L) 100737806(MTHFD2)
CFR: 102506350(MTHFD2) 102507186(MTHFD2L)
CDK: 105091387(MTHFD2L) 105096568(MTHFD2)
BACU: 102999576(MTHFD2) 103005088(MTHFD2L)
LVE: 103070308(MTHFD2L) 103080041(MTHFD2)
OOR: 101271285(MTHFD2) 101284968(MTHFD2L)
DLE: 111169110(MTHFD2) 111187610(MTHFD2L)
PCAD: 102978086 102982589(MTHFD2L) 112067504
ECB: 100053990(MTHFD2) 100056425(MTHFD2L)
EPZ: 103564986(MTHFD2) 103565139(MTHFD2L)
EAI: 106823850(MTHFD2) 106846392(MTHFD2L)
MYB: 102241059(MTHFD2L) 102257615(MTHFD2)
MYD: 102754790(MTHFD2) 102755341(MTHFD2L)
MNA: 107529263(MTHFD2) 107534504(MTHFD2L)
HAI: 109371186(MTHFD2) 109371843(MTHFD2L)
DRO: 112303062(MTHFD2)
PALE: 102884965(MTHFD2) 102885905(MTHFD2L)
RAY: 107502906(MTHFD2) 107515314(MTHFD2L)
MJV: 108397674(MTHFD2L) 108402265(MTHFD2)
LAV: 100656025(MTHFD2) 100662679(MTHFD2L)
MDO: 100023851(MTHFD2L) 100024210(MTHFD2)
SHR: 100915702(MTHFD2L) 100917387(MTHFD2)
PCW: 110209788(MTHFD2L) 110222642(MTHFD2)
OAA: 100081813(MTHFD2) 114814672(MTHFD2L)
GGA: 426126(MTHFD2) 770327(MTHFD2L)
MGP: 100538988(MTHFD2) 100551458(MTHFD2L)
CJO: 107313487(MTHFD2L) 107323669(MTHFD2)
NMEL: 110387225(MTHFD2) 110397997(MTHFD2L)
APLA: 101797763
ACYG: 106041914(MTHFD2L) 106047654(MTHFD2)
TGU: 100222836(MTHFD2) 100224318
LSR: 110470132 110480183(MTHFD2)
SCAN: 103823444 103824667(MTHFD2)
GFR: 102034978(MTHFD2) 102038192(EPGN)
FAB: 101805811(MTHFD2) 101808409(MTHFD2L)
PHI: 102104850(MTHFD2) 102107685(MTHFD2L)
PMAJ: 107203094(MTHFD2L)
CCAE: 111929467 111938875(MTHFD2)
CCW: 104683768(MTHFD2) 104698281
ETL: 114068642(EPGN) 114071513(MTHFD2)
FPG: 101913929(MTHFD2) 101919106(MTHFD2L)
FCH: 102045855(MTHFD2) 102057455(MTHFD2L)
CLV: 102087519(MTHFD2) 102090092
EGZ: 104130378(MTHFD2) 104131554(MTHFD2L)
NNI: 104015875(MTHFD2L) 104019251(MTHFD2)
ACUN: 113479567 113488027(MTHFD2)
PADL: 103917169(MTHFD2) 103917712(MTHFD2L)
AAM: 106484145(MTHFD2) 106491799
ASN: 102380151(MTHFD2L) 102387286(MTHFD2)
AMJ: 102568648(MTHFD2L) 102576181(MTHFD2)
PSS: 102453272(MTHFD2) 102459482(MTHFD2L)
CMY: 102929848(MTHFD2) 102931470(MTHFD2L)
CPIC: 101931359(MTHFD2) 101935770(MTHFD2L)
ACS: 100553649(mthfd2l) 100566586(mthfd2)
PVT: 110072089(MTHFD2) 110090462(MTHFD2L)
PBI: 103051980(MTHFD2) 103060626
PMUR: 107283230(MTHFD2) 107302390(MTHFD2L)
TSR: 106543055(MTHFD2L) 106544036(MTHFD2)
PMUA: 114581905(MTHFD2L) 114602652(MTHFD2)
GJA: 107118751(MTHFD2)
XLA: 108711079 432317(mthfd2.L) 446641(mthfd2l.S)
XTR: 100170462(mthfd2) 100497864(mthfd2l)
NPR: 108784463(MTHFD2L) 108793886(MTHFD2)
DRE: 100004977(mthfd2) 327496(mthfd2l)
IPU: 108255807(mthfd2)
PHYP: 113542646(mthfd2)
AMEX: 103037572(mthfd2) 103042060
EEE: 113581619(mthfd2)
LCO: 104920303(mthfd2) 104923005(mthfd2l)
NCC: 104962129(mthfd2l) 104962309(mthfd2)
OLA: 101160170(mthfd2) 101165643
PRET: 103469985 103470271(mthfd2)
CVG: 107085299(mthfd2l) 107087259(mthfd2)
NFU: 107394218(mthfd2) 107394299
ALIM: 106519077(mthfd2) 106519891(mthfd2l)
POV: 109636983 109638160(mthfd2)
BPEC: 110172444(mthfd2) 110175266
MALB: 109956494 109961515(mthfd2)
ELS: 105014522 105026116(mthfd2)
SFM: 108934776(mthfd2) 108938600
PKI: 111855437 111860038(mthfd2)
LCM: 102351616(MTHFD2) 102356358(MTHFD2L)
CMK: 103177682(mthfd2l) 103191574(mthfd2)
RTP: 109927970(mthfd2)
BFO: 118412686
CIN: 100186867
SPU: 588966
APLC: 110973624
SKO: 100372318
DME: Dmel_CG18466(Nmdmc)
DER: 6552453
DSE: 6607162
DSI: Dsimw501_GD20823(Dsim_GD20823)
DAN: 6501205
DSR: 110186939
DPE: 6594690
DMN: 108155720
DWI: 6650774
DAZ: 108608906
DNV: 108653109
DHE: 111604791
DVI: 6629858
MDE: 101893683
LCQ: 111676766
AAG: 5565520
AME: 551667
BIM: 100742580
BTER: 100648062
CCAL: 108631274
OBB: 114875924
SOC: 105205751
MPHA: 105835617
AEC: 105152165
ACEP: 105625905
PBAR: 105431893
VEM: 105560624
HST: 105186219
DQU: 106744851
CFO: 105256248
LHU: 105671947
PGC: 109854289
PCF: 106784398
NVI: 103316642
CSOL: 105366285
MDL: 103573472
TCA: 662099
DPA: 109538981
ATD: 109603499
NVL: 108559670
BMOR: 101741628
BMAN: 114243353
PMAC: 106709194
PRAP: 111003982
HAW: 110370397
TNL: 113503426
PXY: 105393725
API: 100164363
DNX: 107167708
AGS: 114131363
RMD: 113549835
BTAB: 109041268
CLEC: 106660816
ZNE: 110828188
PVM: 113813400
CSCU: 111629759
PTEP: 107447105
CEL: CELE_K07E3.3(dao-3)
CBR: CBG16896(Cbr-dao-3)
PCAN: 112575041
CRG: 105336517
MYI: 110446618
LAK: 106154809
AQU: 100640189
 » show all
Reference
PMID:8485162
  Authors
Price BD, Laughon A
  Title
The isolation and characterization of a Drosophila gene encoding a putative NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.
  Journal
Biochim Biophys Acta 1173:94-8 (1993)
DOI:10.1016/0167-4781(93)90251-8
  Sequence
LinkDB

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