KEGG   ORTHOLOGY: K00422
Entry
K00422                      KO                                     

Name
E1.10.3.1
Definition
polyphenol oxidase [EC:1.10.3.1]
Pathway
ko00350  Tyrosine metabolism
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00422  E1.10.3.1; polyphenol oxidase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00422  E1.10.3.1; polyphenol oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.1  catechol oxidase
     K00422  E1.10.3.1; polyphenol oxidase
Other DBs
RN: R00031 R00045 R02078
GO: 0004097
Genes
CPAP: 110813716 110813822 110817816 110817849 110817859 110820923 110824768
CIT: 102625572
CIC: CICLE_v10014693mg
TCC: 18596894 18596895 18596896 18596897 18596899 18607763
GRA: 105771487 105772626 105772676 105773953 105795312 105798965
GHI: 107886301 107888998 107891789 107901674 107901676 107908785 107923401 107927826 107940403 107941595 107955348 107960202
GAB: 108456176 108475875 108478462 108481031 108482137 108484704 108486759
DZI: 111278202 111278203 111282397 111286844 111308257 111318757
EGR: 104428733 104441046 104442643
GMX: 100037473 100037474 100785410 100789730 100792012 100798184 100798709 100801369 100801754 100802289 100802763 100803171 100803874
CAM: 101512236
LJA: Lj3g3v0278890.1(Lj3g3v0278890.1) Lj3g3v1729190.1(Lj3g3v1729190.1) Lj6g3v2044610.1(Lj6g3v2044610.1)
RCU: 8278545
JCU: 105649503
MESC: 110605532
DOSA: Os01t0793300-01(Os01g0793300) Os04t0624500-01(Os04g0624500)
ATS: 109735375(LOC109735375) 109747401(LOC109747401) 109762318(LOC109762318) 109762325(LOC109762325)
AOF: 109821572
CTHE: Chro_1305
NDE: NIDE3206
 » show all
Reference
PMID:8098228
  Authors
Newman SM, Eannetta NT, Yu H, Prince JP, de Vicente MC, Tanksley SD, Steffens JC
  Title
Organisation of the tomato polyphenol oxidase gene family.
  Journal
Plant Mol Biol 21:1035-51 (1993)
DOI:10.1007/BF00023601
  Sequence
[sly:101259357]
LinkDB

KEGG   ENZYME: 1.10.3.1
Entry
EC 1.10.3.1                 Enzyme                                 

Name
catechol oxidase;
diphenol oxidase;
o-diphenolase;
polyphenol oxidase;
pyrocatechol oxidase;
dopa oxidase;
catecholase;
o-diphenol:oxygen oxidoreductase;
o-diphenol oxidoreductase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
Sysname
1,2-benzenediol:oxygen oxidoreductase
Reaction(IUBMB)
2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O [RN:R00058]
Reaction(KEGG)
R00058;
(other) R00031 R00045 R00080 R02078
Substrate
catechol [CPD:C00090];
O2 [CPD:C00007]
Product
1,2-benzoquinone [CPD:C02351];
H2O [CPD:C00001]
Comment
A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols.
It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.
History
EC 1.10.3.1 created 1961, deleted 1972, reinstated 1978
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00422  polyphenol oxidase
Genes
CPAP: 110813716 110813822 110817816 110817849 110817859 110820923 110824768
CIT: 102625572
CIC: CICLE_v10014693mg
TCC: 18596894 18596895 18596896 18596897 18596899 18607763
GRA: 105771487 105772626 105772676 105773953 105795312 105798965
GHI: 107886301 107888998 107891789 107901674 107901676 107908785 107923401 107927826 107940403 107941595 107955348 107960202
GAB: 108456176 108475875 108478462 108481031 108482137 108484704 108486759
DZI: 111278202 111278203 111282397 111286844 111308257 111318757
EGR: 104428733 104441046 104442643
GMX: 100037473 100037474 100785410 100789730 100792012 100798184 100798709 100801369 100801754 100802289 100802763 100803171 100803874
CAM: 101512236
LJA: Lj3g3v0278890.1(Lj3g3v0278890.1) Lj3g3v1729190.1(Lj3g3v1729190.1) Lj6g3v2044610.1(Lj6g3v2044610.1)
RCU: 8278545
JCU: 105649503
MESC: 110605532
DOSA: Os01t0793300-01(Os01g0793300) Os04t0624500-01(Os04g0624500)
ATS: 109735375(LOC109735375) 109747401(LOC109747401) 109762318(LOC109762318) 109762325(LOC109762325)
AOF: 109821572
CTHE: Chro_1305
NDE: NIDE3206
 » show all
Reference
1
  Authors
Brown, F.C. and Ward, D.N.
  Title
Preparation of a soluble mammalian tyrosinase.
  Journal
J Am Chem Soc 79:2647-2648 (1957)
Reference
2
  Authors
Dawson, C.R. and Tarpley, W.B.
  Title
The copper oxidases.
  Journal
In: Sumner, J.B. and Myrback, K. (Eds.), The Enzymes, 1st ed., vol. 2, Academic Press, New York, 1951, p. 454-498.
Reference
3  [PMID:16742427]
  Authors
Gregory RP, Bendall DS
  Title
The purification and some properties of the polyphenol oxidase from tea (Camellia sinensis L.).
  Journal
Biochem J 101:569-81 (1966)
DOI:10.1042/bj1010569
Reference
4  [PMID:13288597]
  Authors
MASON HS.
  Title
Structures and functions of the phenolase complex.
  Journal
Nature 177:79-81 (1956)
DOI:10.1038/177079a0
Reference
5
  Authors
Mayer, A.M. and Harel, E.
  Title
Polyphenol oxidases in plants.
  Journal
Phytochemistry 18:193-215 (1979)
Reference
6  [PMID:5842066]
  Authors
Patil SS, Zucker M.
  Title
Potato phenolases. Purification and properties.
  Journal
J Biol Chem 240:3938-43 (1965)
Reference
7  [PMID:4965136]
  Authors
Pomerantz SH, Warner MC.
  Title
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
  Journal
J Biol Chem 242:5308-14 (1967)
Reference
8
  Authors
Robb, D.A.
  Title
`Tyrosinase.
  Journal
In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, CRC Press, Boca Raton, FL, 1984, p. 207-240.
Reference
9  [PMID:11900522]
  Authors
Gerdemann C, Eicken C, Krebs B
  Title
The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins.
  Journal
Acc Chem Res 35:183-91 (2002)
DOI:10.1021/ar990019a
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.1
IUBMB Enzyme Nomenclature: 1.10.3.1
ExPASy - ENZYME nomenclature database: 1.10.3.1
BRENDA, the Enzyme Database: 1.10.3.1
CAS: 9002-10-2
LinkDB

KEGG   REACTION: R02078
Entry
R02078                      Reaction                               

Name
L-Tyrosine,L-dopa:oxygen oxidoreductase
Definition
3,4-Dihydroxy-L-phenylalanine + L-Tyrosine + Oxygen <=> Dopaquinone + 3,4-Dihydroxy-L-phenylalanine + H2O
Equation
Reaction class
RC00046  C00082_C00355
RC00180  C00355_C00822
Enzyme
1.10.3.1        1.14.18.1
Pathway
rn00350  Tyrosine metabolism
rn00965  Betalain biosynthesis
rn01100  Metabolic pathways
Orthology
K00422  polyphenol oxidase [EC:1.10.3.1]
K00505  tyrosinase [EC:1.14.18.1]
LinkDB

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