KEGG   ORTHOLOGY: K00435Help
Entry
K00435                      KO                                     

Name
hemQ
Definition
hydrogen peroxide-dependent heme synthase [EC:1.3.98.5]
Pathway
ko00860  Porphyrin and chlorophyll metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K00435  hemQ; hydrogen peroxide-dependent heme synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.98  With other, known, physiological acceptors
    1.3.98.5  hydrogen peroxide-dependent heme synthase
     K00435  hemQ; hydrogen peroxide-dependent heme synthase
BRITE hierarchy
Other DBs
RN: R11522
COG: COG3253
Genes
SDO: SD1155_05710
BSU: BSU37670(ywfI)
BSR: I33_3915
BSL: A7A1_0186
BSH: BSU6051_37670(ywfI)
BSY: I653_18480
BSUT: BSUB_04003(hemQ)
BSUL: BSUA_04003(hemQ)
BSUS: Q433_20750
BSS: BSUW23_18605(ywfI)
BST: GYO_4153
BSO: BSNT_10425(ywfI)
BSQ: B657_37670(hemQ)
BSX: C663_3672(ywfI)
BLI: BL03956(ywfI)
BLD: BLi03998(ywfI)
BLH: BaLi_c40120(ywfI)
BAQ: BACAU_3515(ywfI)
BYA: BANAU_3668(ywfI)
BAMP: B938_17890
BAML: BAM5036_3416(hemQ)
BAMA: RBAU_3624(hemQ)
BAMN: BASU_3400(hemQ)
BAMB: BAPNAU_3682(ywfI)
BAMT: AJ82_19675
BAMY: V529_37580(ywfI)
BAO: BAMF_3599(ywfI)
BAZ: BAMTA208_19065(ywfI)
BQL: LL3_03911(ywfI)
BXH: BAXH7_03903(ywfI)
BQY: MUS_4145(ywfI)
BAMI: KSO_001630
BAMC: U471_36310
BAMF: U722_18625
BHA: BH3825
BAN: BA_5637
BAR: GBAA_5637
BAT: BAS5239
BAI: BAA_5664
BANT: A16_56490
BANR: A16R_57170
BANS: BAPAT_5404
BANV: DJ46_4284
BCE: BC5388
BCA: BCE_5517
BCQ: BCQ_5229
BCX: BCA_5540
BNC: BCN_5316
BCF: bcf_27060
BCER: BCK_08415
BTL: BALH_4887
BTT: HD73_5801
BTHI: BTK_28590
BTM: MC28_4621
BTI: BTG_21445
BTW: BF38_1111
BWW: bwei_4395
BMYO: BG05_621
BMYC: DJ92_2476
BCL: ABC3912
BPU: BPUM_3416
BPUM: BW16_18140
BPUS: UP12_17585
BPF: BpOF4_07220(ywfI)
BMQ: BMQ_5203
BMD: BMD_5189
BMEG: BG04_2197
BAG: Bcoa_1405
BCOA: BF29_2111
BJS: MY9_3858
BACW: QR42_17140
BACP: SB24_11265
BACB: OY17_01095
BACO: OXB_1378
BACY: QF06_17275
BACL: BS34A_40850(ywfI)
BALM: BsLM_3797
BEO: BEH_23695
BGY: BGLY_4402
BBEV: BBEV_0110
OIH: OB3023
GKA: GK3416
GTN: GTNG_3362
GGH: GHH_c35120(ywfI)
AFL: Aflv_2762
AAMY: GFC30_304
LSP: Bsph_0946
HLI: HLI_14195
PSYO: PB01_03105
BSE: Bsel_3224
SAU: SA0544
SAV: SAV0587
SAW: SAHV_0585
SAM: MW0542
SAS: SAS0546
SAR: SAR0593
SAC: SACOL0633
SAE: NWMN_0550
SAD: SAAV_0549
SUC: ECTR2_540
SUZ: MS7_0576
SUG: SAPIG0661
SAUA: SAAG_01009
SAUS: SA40_0528
SAUU: SA957_0543
SAUG: SA268_0541
SAUF: X998_0628
SAB: SAB0537c
SAUB: C248_0662
SAUM: BN843_5800
SAUC: CA347_602
SAUR: SABB_00636
SAUI: AZ30_02965
SAUD: CH52_02825
SAMS: NI36_02925
SEP: SE0358
SER: SERP0235
SEPP: SEB_00280
SEPS: DP17_1665
SHA: SH2405
SSP: SSP2125
SCA: SCA_0241
SDT: SPSE_2174
SPAS: STP1_1673
SSCH: LH95_10290
SSCZ: RN70_11025
SAGQ: EP23_11460
MCL: MCCL_1834
MCAK: MCCS_23810
LMO: lmo2113
LMOE: BN418_2544
LMOB: BN419_2550
LMOD: LMON_2187
LMOW: AX10_04825
LMOQ: LM6179_2888(hemQ)
LMR: LMR479A_2224(hemQ)
LMOM: IJ09_14370
LMP: MUO_10840
LMOX: AX24_08430
LMQ: LMM7_2215
LMS: LMLG_0313
LMOK: CQ02_10950
LIN: lin2218
LWE: lwe2132
LSG: lse_2102
LIV: LIV_2104
ESI: Exig_0217
EAN: Eab7_0205
PPY: PPE_03879
PPM: PPSC2_20370(ywfI)
PPO: PPM_4082(ywfI)
PPOL: X809_36505
PPQ: PPSQR21_041190(ywfI)
PPOY: RE92_16820
PMW: B2K_05800
PSAB: PSAB_19360
PRI: PRIO_5637
PSWU: SY83_00030
ASOC: CB4_01234
AAC: Aaci_1765
AAD: TC41_1664
BTS: Btus_1292
SIV: SSIL_3430
JEO: JMA_31060
TMR: Tmar_0490
SAY: TPY_1863
VPR: Vpar_0219
LPIL: LIP_0706
BAST: BAST_0811
MKC: kam1_945
RUL: UC8_30990
TTF: THTE_3205
ABAS: ACPOL_2493
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Dailey TA, Boynton TO, Albetel AN, Gerdes S, Johnson MK, Dailey HA
  Title
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
  Journal
J Biol Chem 285:25978-86 (2010)
DOI:10.1074/jbc.M110.142604
Reference
  Authors
Dailey HA, Gerdes S
  Title
HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria.
  Journal
Arch Biochem Biophys 574:27-35 (2015)
DOI:10.1016/j.abb.2015.02.017
Reference
  Authors
Celis AI, Gauss GH, Streit BR, Shisler K, Moraski GC, Rodgers KR, Lukat-Rodgers GS, Peters JW, DuBois JL
  Title
Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates in Coproheme Decarboxylase (HemQ).
  Journal
J Am Chem Soc 139:1900-1911 (2017)
DOI:10.1021/jacs.6b11324
  Sequence
LinkDB All DBs

KEGG   ENZYME: 1.3.98.5Help
Entry
EC 1.3.98.5                 Enzyme                                 

Name
hydrogen peroxide-dependent heme synthase;
coproheme III oxidative decarboxylase;
hemQ (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
Fe-coproporphyrin III:hydrogen peroxide oxidoreductase (decarboxylating)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O (overall reaction) [RN:R11522];
(1a) Fe-coproporphyrin III + H2O2 = harderoheme III + CO2 + 2 H2O [RN:R12454];
(1b) harderoheme III + H2O2 = protoheme + CO2 + 2 H2O [RN:R12455]
Reaction(KEGG)
Substrate
Fe-coproporphyrin III [CPD:C21284];
H2O2 [CPD:C00027];
harderoheme III [CPD:C22173]
Product
protoheme [CPD:C00032];
CO2 [CPD:C00011];
H2O [CPD:C00001];
harderoheme III [CPD:C22173]
Comment
The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase.
History
EC 1.3.98.5 created 2019
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00435  hydrogen peroxide-dependent heme synthase
Genes
SDO: SD1155_05710
BSU: BSU37670(ywfI)
BSR: I33_3915
BSL: A7A1_0186
BSH: BSU6051_37670(ywfI)
BSY: I653_18480
BSUT: BSUB_04003(hemQ)
BSUL: BSUA_04003(hemQ)
BSUS: Q433_20750
BSS: BSUW23_18605(ywfI)
BST: GYO_4153
BSO: BSNT_10425(ywfI)
BSQ: B657_37670(hemQ)
BSX: C663_3672(ywfI)
BLI: BL03956(ywfI)
BLD: BLi03998(ywfI)
BLH: BaLi_c40120(ywfI)
BAQ: BACAU_3515(ywfI)
BYA: BANAU_3668(ywfI)
BAMP: B938_17890
BAML: BAM5036_3416(hemQ)
BAMA: RBAU_3624(hemQ)
BAMN: BASU_3400(hemQ)
BAMB: BAPNAU_3682(ywfI)
BAMT: AJ82_19675
BAMY: V529_37580(ywfI)
BAO: BAMF_3599(ywfI)
BAZ: BAMTA208_19065(ywfI)
BQL: LL3_03911(ywfI)
BXH: BAXH7_03903(ywfI)
BQY: MUS_4145(ywfI)
BAMI: KSO_001630
BAMC: U471_36310
BAMF: U722_18625
BHA: BH3825
BAN: BA_5637
BAR: GBAA_5637
BAT: BAS5239
BAI: BAA_5664
BANT: A16_56490
BANR: A16R_57170
BANS: BAPAT_5404
BANV: DJ46_4284
BCE: BC5388
BCA: BCE_5517
BCQ: BCQ_5229
BCX: BCA_5540
BNC: BCN_5316
BCF: bcf_27060
BCER: BCK_08415
BTL: BALH_4887
BTT: HD73_5801
BTHI: BTK_28590
BTM: MC28_4621
BTI: BTG_21445
BTW: BF38_1111
BWW: bwei_4395
BMYO: BG05_621
BMYC: DJ92_2476
BCL: ABC3912
BPU: BPUM_3416
BPUM: BW16_18140
BPUS: UP12_17585
BPF: BpOF4_07220(ywfI)
BMQ: BMQ_5203
BMD: BMD_5189
BMEG: BG04_2197
BAG: Bcoa_1405
BCOA: BF29_2111
BJS: MY9_3858
BACW: QR42_17140
BACP: SB24_11265
BACB: OY17_01095
BACO: OXB_1378
BACY: QF06_17275
BACL: BS34A_40850(ywfI)
BALM: BsLM_3797
BEO: BEH_23695
BGY: BGLY_4402
BBEV: BBEV_0110
OIH: OB3023
GKA: GK3416
GTN: GTNG_3362
GGH: GHH_c35120(ywfI)
AFL: Aflv_2762
AAMY: GFC30_304
LSP: Bsph_0946
HLI: HLI_14195
PSYO: PB01_03105
BSE: Bsel_3224
SAU: SA0544
SAV: SAV0587
SAW: SAHV_0585
SAM: MW0542
SAS: SAS0546
SAR: SAR0593
SAC: SACOL0633
SAE: NWMN_0550
SAD: SAAV_0549
SUC: ECTR2_540
SUZ: MS7_0576
SUG: SAPIG0661
SAUA: SAAG_01009
SAUS: SA40_0528
SAUU: SA957_0543
SAUG: SA268_0541
SAUF: X998_0628
SAB: SAB0537c
SAUB: C248_0662
SAUM: BN843_5800
SAUC: CA347_602
SAUR: SABB_00636
SAUI: AZ30_02965
SAUD: CH52_02825
SAMS: NI36_02925
SEP: SE0358
SER: SERP0235
SEPP: SEB_00280
SEPS: DP17_1665
SHA: SH2405
SSP: SSP2125
SCA: SCA_0241
SDT: SPSE_2174
SPAS: STP1_1673
SSCH: LH95_10290
SSCZ: RN70_11025
SAGQ: EP23_11460
MCL: MCCL_1834
MCAK: MCCS_23810
LMO: lmo2113
LMOE: BN418_2544
LMOB: BN419_2550
LMOD: LMON_2187
LMOW: AX10_04825
LMOQ: LM6179_2888(hemQ)
LMR: LMR479A_2224(hemQ)
LMOM: IJ09_14370
LMP: MUO_10840
LMOX: AX24_08430
LMQ: LMM7_2215
LMS: LMLG_0313
LMOK: CQ02_10950
LIN: lin2218
LWE: lwe2132
LSG: lse_2102
LIV: LIV_2104
ESI: Exig_0217
EAN: Eab7_0205
PPY: PPE_03879
PPM: PPSC2_20370(ywfI)
PPO: PPM_4082(ywfI)
PPOL: X809_36505
PPQ: PPSQR21_041190(ywfI)
PPOY: RE92_16820
PMW: B2K_05800
PSAB: PSAB_19360
PRI: PRIO_5637
PSWU: SY83_00030
ASOC: CB4_01234
AAC: Aaci_1765
AAD: TC41_1664
BTS: Btus_1292
SIV: SSIL_3430
JEO: JMA_31060
TMR: Tmar_0490
SAY: TPY_1863
VPR: Vpar_0219
LPIL: LIP_0706
BAST: BAST_0811
MKC: kam1_945
RUL: UC8_30990
TTF: THTE_3205
ABAS: ACPOL_2493
 » show all
Taxonomy
Reference
1  [PMID:20543190]
  Authors
Dailey TA, Boynton TO, Albetel AN, Gerdes S, Johnson MK, Dailey HA
  Title
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
  Journal
J Biol Chem 285:25978-86 (2010)
DOI:10.1074/jbc.M110.142604
Reference
2  [PMID:26083961]
  Authors
Celis AI, Streit BR, Moraski GC, Kant R, Lash TD, Lukat-Rodgers GS, Rodgers KR, DuBois JL
  Title
Unusual Peroxide-Dependent, Heme-Transforming Reaction Catalyzed by HemQ.
  Journal
Biochemistry 54:4022-32 (2015)
Reference
3  [PMID:27758026]
  Authors
Hofbauer S, Mlynek G, Milazzo L, Puhringer D, Maresch D, Schaffner I, Furtmuller PG, Smulevich G, Djinovic-Carugo K, Obinger C
  Title
Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies.
  Journal
FEBS J 283:4386-4401 (2016)
  Sequence
[lmo:lmo2113]
Reference
4  [PMID:27936663]
  Authors
Celis AI, Gauss GH, Streit BR, Shisler K, Moraski GC, Rodgers KR, Lukat-Rodgers GS, Peters JW, DuBois JL.
  Title
Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates in Coproheme Decarboxylase (HemQ).
  Journal
J Am Chem Soc (2017)
DOI:10.1021/jacs.6b11324
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.5
IUBMB Enzyme Nomenclature: 1.3.98.5
ExPASy - ENZYME nomenclature database: 1.3.98.5
BRENDA, the Enzyme Database: 1.3.98.5
LinkDB All DBs

KEGG   REACTION: R11522Help
Entry
R11522                      Reaction                               

Name
Fe-coproporphyrin III:hydrogen peroxide oxidoreductase (decarboxylating)
Definition
Fe-coproporphyrin III + 2 Hydrogen peroxide <=> Heme + 2 CO2 + 4 H2O
Equation
C21284 + 2 C00027 <=> C00032 + 2 C00011 + 4 C00001
Comment
two-step reaction (see R12454+R12455)
Reaction class
RC00884  C00032_C21284
Enzyme
Pathway
rn00860  Porphyrin and chlorophyll metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00435  hydrogen peroxide-dependent heme synthase [EC:1.3.98.5]
Other DBs
RHEA: 56519
LinkDB All DBs

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