KEGG   ORTHOLOGY: K00440Help
Entry
K00440                      KO                                     

Name
frhA
Definition
coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00440  frhA; coenzyme F420 hydrogenase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00440  frhA; coenzyme F420 hydrogenase subunit alpha
BRITE hierarchy
Other DBs
RN: R03025
COG: COG3259
GO: 0050454
Genes
TAM: Theam_1117
DTE: Dester_0449
MJA: MJ_0727
MFE: Mefer_1242
MVU: Metvu_0629 Metvu_1282
MFS: MFS40622_0950 MFS40622_1445
MIF: Metin_0065 Metin_0515
MJH: JH146_1154 JH146_1534
MIG: Metig_0358 Metig_1200 Metig_1795
MMP: MMP0820(frcA) MMP1382(fruA)
MAE: Maeo_1045
METF: CFE53_05470(frhA)
MTH: MTH_1300
MMG: MTBMA_c16860(frhA)
METC: MTCT_1180
MWO: MWSIV6_1689(frhA)
METE: tca_01254
METK: FVF72_05075(frhA)
MST: Msp_1302(frhA)
MRU: mru_2064(frhA)
MSI: Msm_1124
MEB: Abm4_1634(frhA)
MMIL: sm9_0191(frhA)
MEYE: TL18_09880
MOL: YLM1_1805
METH: MBMB1_1911(frhA)
MFC: BRM9_2252(frhA)
MFI: DSM1535_1184(frhA)
MCUB: MCBB_2187(frhA3)
METT: CIT01_04675(frhA)
METO: CIT02_07975(frhA)
MFV: Mfer_1032
MKA: MK0931
TON: TON_1559
TGA: TGAM_0068(frhA)
THE: GQS_02355
THM: CL1_1151
TNU: BD01_1902
TEU: TEU_01935
MAC: MA_0975(frhA)
MBAK: MSBR3_2973
MMA: MM_3045
MMAC: MSMAC_2996
MTHR: MSTHT_1418
MTHE: MSTHC_1871
MHOR: MSHOH_2436
MFZ: AOB57_006185(frhA)
MHU: Mhun_2332
MLA: Mlab_0015
MBG: BN140_1378(frhA)
MPI: Mpet_0590
MBN: Mboo_0479
MPL: Mpal_0084
MPD: MCP_2409(frhA-1) MCP_2452(frhA-2)
MEZ: Mtc_1001(frhA-1) Mtc_2127(frhA-2)
RCI: RCIX2138(frhA-2) RCIX2388(frhA-1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1300]
LinkDB All DBs

KEGG   ORTHOLOGY: K00441Help
Entry
K00441                      KO                                     

Name
frhB
Definition
coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00441  frhB; coenzyme F420 hydrogenase subunit beta
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00441  frhB; coenzyme F420 hydrogenase subunit beta
BRITE hierarchy
Other DBs
RN: R03025
COG: COG1035
GO: 0050454
Genes
TPS: THAPSDRAFT_14482
BNG: EH206_14015
PBM: CL52_07485
MICC: AUP74_01017
MAGA: Mag101_14625
TMB: Thimo_3072
HHA: Hhal_1640
HHK: HH1059_07720
HHC: M911_14490
EBS: ECTOBSL9_0693
RGE: RGE_14160
DFL: DFE_1763
DRT: Dret_0422
DSF: UWK_00468
DOL: Dole_1150
DBR: Deba_0887
RPA: RPA1501
RPB: RPB_4023
RPC: RPC_1245
RPD: RPD_3777
RPE: RPE_1300
RPT: Rpal_1688
RVA: Rvan_2125
JAN: Jann_0300
RDE: RD1_3988
DSH: Dshi_3268
SSAN: NX02_24175
BLAS: BSY18_1802
RRU: Rru_A0937
RRF: F11_04830
RCE: RC1_0144(frhB)
RPM: RSPPHO_01934(frhB)
BPB: bpr_I2415
PTH: PTH_1492(FrhB)
AWO: Awo_c13400(frhB)
CTHM: CFE_1724
CHY: CHY_1362
MCHE: BB28_08225
ROP: ROP_54820
SALU: DC74_399
SALL: SAZ_02480
STRE: GZL_08882
ACH: Achl_2944
MPH: MLP_48650
NML: Namu_4481
RXY: Rxyl_0964
DET: DET0214
DMD: dcmb_217
TTR: Tter_1334
MMP: MMP0083 MMP0817(frcB) MMP1385(fruB)
MWO: MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5)
MST: Msp_1305(frhB)
MRU: mru_2061(frhB1) mru_2081(frhB2)
MEB: Abm4_0826(frhB2) Abm4_1630(frhB1)
MMIL: sm9_0194(frhB1) sm9_1453(frhB2)
MOL: YLM1_1808
METH: MBMB1_1414 MBMB1_1908(frhB)
MFC: BRM9_0650(frhB2) BRM9_2249(frhB)
MCUB: MCBB_1652(frhB1) MCBB_2184(frhB3)
TON: TON_1561
TGA: TGAM_0066(frhB)
THE: GQS_02345
THM: CL1_1149
THS: TES1_1499
TNU: BD01_1900
TEU: TEU_01945
MAC: MA_0978(frhB) MA_4220 MA_4520
MBU: Mbur_2261
MTP: Mthe_0174
MCJ: MCON_2320(frhB)
MHI: Mhar_2358
MLA: Mlab_0012
MEMA: MMAB1_1766(frhB) MMAB1_2005
MPD: MCP_2174(frhB-1) MCP_2412(frhB-2) MCP_2454(frhB-3)
MEZ: Mtc_0999(frhB-1) Mtc_1195(frhB-3) Mtc_2130(frhB-2)
RCI: RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2391(frhB-1) RCIX2759(frhB-4)
NPH: NP_4006A
HME: HFX_6483
NAT: NJ7G_0302
SALI: L593_06175
BARC: AOA65_2033(frhB)
LOKI: Lokiarch_07380(frhB_1) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_17890(fpoF_2) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1297]
LinkDB All DBs

KEGG   ORTHOLOGY: K00442Help
Entry
K00442                      KO                                     

Name
frhD
Definition
coenzyme F420 hydrogenase subunit delta
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00442  frhD; coenzyme F420 hydrogenase subunit delta
BRITE hierarchy
Other DBs
RN: R03025
COG: COG0680
Genes
DAF: Desaf_1040
DPS: DP1008
DPR: Despr_1739
DAL: Dalk_4967
DAT: HRM2_11700(hyaD2)
DWD: DSCW_39770
DAO: Desac_1002
SFU: Sfum_2220 Sfum_3530
DET: DET0616
DEH: cbdbA598
DEV: DhcVS_554
DMC: btf_576
DMD: dcmb_622
DMG: GY50_0542(hycl)
MMP: MMP0819(frcD) MMP1337 MMP1383(fruD)
METF: CFE53_03465(frhD) CFE53_05475(frhD)
MTH: MTH_1299
MMG: MTBMA_c16850(frhD)
METC: MTCT_1179
MWO: MWSIV6_1688(frhD)
METE: tca_01253(hyaD)
METK: FVF72_05080(frhD)
MST: Msp_1303(frhD) Msp_1514
MRU: mru_2063(frhD)
MSI: Msm_1123
MEB: Abm4_1633(frhD)
MMIL: sm9_0190(frhD1) sm9_0192(frhD2)
MEYE: TL18_09875
MOL: YLM1_1806
METH: MBMB1_1910(frhD)
MFC: BRM9_2251(frhD)
MFI: DSM1535_1183(frhD)
MCUB: MCBB_2186(frhD)
METT: CIT01_04670(frhD)
METO: CIT02_07980(frhD)
MFV: Mfer_1033
MKA: MK1624(hyaD_2)
MAC: MA_0976(frhD)
MBAR: MSBR2_2977
MBAK: MSBR3_2972
MMA: MM_3044
MMAC: MSMAC_2997
MTHR: MSTHT_1417
MTHE: MSTHC_1872
MHOR: MSHOH_2437
MFZ: AOB57_006180(frhD)
MHU: Mhun_2331
MLA: Mlab_0014
MBG: BN140_1379(frhD1) BN140_2359(frhD3)
MEMA: MMAB1_1764(frhD)
MBN: Mboo_0478
MPL: Mpal_0085
MPD: MCP_2410(frhD)
MEZ: Mtc_2128(frhD)
RCI: RCIA172(frhD-1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1299]
LinkDB All DBs

KEGG   ORTHOLOGY: K00443Help
Entry
K00443                      KO                                     

Name
frhG
Definition
coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00443  frhG; coenzyme F420 hydrogenase subunit gamma
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.12  Acting on hydrogen as donor
   1.12.98  With other, known, physiological acceptors
    1.12.98.1  coenzyme F420 hydrogenase
     K00443  frhG; coenzyme F420 hydrogenase subunit gamma
BRITE hierarchy
Other DBs
RN: R03025
COG: COG1941
GO: 0050454
Genes
TAM: Theam_1118
DTE: Dester_0450
MJA: MJ_0031 MJ_0726
MFE: Mefer_1240
MVU: Metvu_0630 Metvu_1284
MFS: MFS40622_0948 MFS40622_1446
MIF: Metin_0513
MJH: JH146_1153 JH146_1536
MIG: Metig_0359 Metig_1202 Metig_1793
MMP: MMP0818(frcG) MMP1384(fruG)
MAE: Maeo_1043
METF: CFE53_05480(frhG)
MTH: MTH_1298
MMG: MTBMA_c16840(frhG)
METC: MTCT_1178
MWO: MWSIV6_1687(frhG)
METE: tca_01252(ndhK)
METK: FVF72_05085(frhG)
MST: Msp_1304(frhG)
MRU: mru_2062(frhG)
MSI: Msm_1122
MEB: Abm4_1632(frhG)
MMIL: sm9_0193(frhG)
MEYE: TL18_09870
MOL: YLM1_1807
METH: MBMB1_1909(frhG)
MFC: BRM9_2250(frhG)
MFI: DSM1535_1182(frhG)
MCUB: MCBB_2185(frhG)
METT: CIT01_04665(frhG)
METO: CIT02_07985(frhG)
MFV: Mfer_1034
TON: TON_1560
TGA: TGAM_0067(frhG)
THE: GQS_02350
THM: CL1_1150
THS: TES1_1500
TNU: BD01_1901
TEU: TEU_01940
MAC: MA_0977(frhG)
MBAK: MSBR3_2971
MMA: MM_3043
MMAC: MSMAC_2998
MTHR: MSTHT_1416
MTHE: MSTHC_1873
MHOR: MSHOH_2438
MFZ: AOB57_006175(frhG)
MHU: Mhun_2330
MLA: Mlab_0013
MBG: BN140_1380(frhG)
MEMA: MMAB1_1765(frhG)
MPI: Mpet_0592
MBN: Mboo_0477
MPL: Mpal_0086
MPD: MCP_2411(frhG-1) MCP_2453(frhG-2)
MEZ: Mtc_1000(frhG-1) Mtc_2129(frhG-2)
RCI: RCIX2137(frhG-2) RCIX2390(frhG-1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2207102
  Authors
Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT
  Title
Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.
  Journal
Biochemistry 29:7237-44 (1990)
DOI:10.1021/bi00483a011
  Sequence
[mth:MTH_1298]
LinkDB All DBs

KEGG   ENZYME: 1.12.98.1Help
Entry
EC 1.12.98.1                Enzyme                                 

Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:R03025]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized coenzyme F420 [CPD:C00876]
Product
reduced coenzyme F420 [CPD:C01080]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methylviologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00440  coenzyme F420 hydrogenase subunit alpha
K00441  coenzyme F420 hydrogenase subunit beta
K00443  coenzyme F420 hydrogenase subunit gamma
Genes
TPS: THAPSDRAFT_14482
BNG: EH206_14015
PBM: CL52_07485
MICC: AUP74_01017
MAGA: Mag101_14625
TMB: Thimo_3072
HHA: Hhal_1640
HHK: HH1059_07720
HHC: M911_14490
EBS: ECTOBSL9_0693
RGE: RGE_14160
DFL: DFE_1763
DRT: Dret_0422
DSF: UWK_00468
DOL: Dole_1150
DBR: Deba_0887
RPA: RPA1501
RPB: RPB_4023
RPC: RPC_1245
RPD: RPD_3777
RPE: RPE_1300
RPT: Rpal_1688
RVA: Rvan_2125
JAN: Jann_0300
RDE: RD1_3988
DSH: Dshi_3268
SSAN: NX02_24175
BLAS: BSY18_1802
RRU: Rru_A0937
RRF: F11_04830
RCE: RC1_0144(frhB)
RPM: RSPPHO_01934(frhB)
BPB: bpr_I2415
PTH: PTH_1492(FrhB)
AWO: Awo_c13400(frhB)
CTHM: CFE_1724
CHY: CHY_1362
MCHE: BB28_08225
ROP: ROP_54820
SALU: DC74_399
SALL: SAZ_02480
STRE: GZL_08882
ACH: Achl_2944
MPH: MLP_48650
NML: Namu_4481
RXY: Rxyl_0964
DET: DET0214
DMD: dcmb_217
TTR: Tter_1334
MMP: MMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MWO: MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
MST: Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
MRU: mru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MEB: Abm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMIL: sm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
METH: MBMB1_1414 MBMB1_1908(frhB) MBMB1_1909(frhG) MBMB1_1911(frhA)
MFC: BRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MCUB: MCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
TGA: TGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
MAC: MA_0975(frhA) MA_0977(frhG) MA_0978(frhB) MA_4220 MA_4520
MBU: Mbur_2261
MTP: Mthe_0174
MCJ: MCON_2320(frhB)
MHI: Mhar_2358
MBG: BN140_1378(frhA) BN140_1380(frhG) BN140_1381(frhB) BN140_1566
MPD: MCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZ: Mtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCI: RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
NPH: NP_4006A
HME: HFX_6483
NAT: NJ7G_0302
SALI: L593_06175
BARC: AOA65_2033(frhB)
LOKI: Lokiarch_07380(frhB_1) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_17890(fpoF_2) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
 » show all
Taxonomy
Reference
1  [PMID:6786341]
  Authors
Adams MW, Mortenson LE, Chen JS.
  Title
Hydrogenase.
  Journal
Biochim Biophys Acta 594:105-76 (1980)
Reference
2  [PMID:6211447]
  Authors
Yamazaki S.
  Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
  Journal
J Biol Chem 257:7926-9 (1982)
Reference
3  [PMID:3663585]
  Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
  Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
  Journal
Biochemistry 26:4219-27 (1987)
  Sequence
Reference
4  [PMID:3121317]
  Authors
Muth E, Morschel E, Klein A.
  Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
  Journal
Eur J Biochem 169:571-7 (1987)
DOI:10.1111/j.1432-1033.1987.tb13647.x
Reference
5  [PMID:2738024]
  Authors
Baron SF, Ferry JG.
  Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 171:3846-53 (1989)
DOI:10.1128/JB.171.7.3846-3853.1989
Other DBs
ExplorEnz - The Enzyme Database: 1.12.98.1
IUBMB Enzyme Nomenclature: 1.12.98.1
ExPASy - ENZYME nomenclature database: 1.12.98.1
BRENDA, the Enzyme Database: 1.12.98.1
CAS: 9027-05-8
LinkDB All DBs

KEGG   REACTION: R03025Help
Entry
R03025                      Reaction                               

Name
Hydrogen:Coenzyme F420 oxidoreductase
Definition
Coenzyme F420 + Hydrogen <=> Reduced coenzyme F420
Equation
Reaction class
RC02628  C00876_C01080
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00440  coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1]
K00441  coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1]
K00442  coenzyme F420 hydrogenase subunit delta
K00443  coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1]
Other DBs
RHEA: 23763
LinkDB All DBs

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